tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate
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- CAS號(hào):
- 1420859-80-8
- 英文名:
- tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate
- 英文別名:
- 1-Boc-3-(2-bromoethyl)azetidine;tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate;3-(2-Bromo-ethyl)-azetidine-1-carboxylic acid tert-butyl ester;1-Azetidinecarboxylic acid, 3-(2-bromoethyl)-, 1,1-dimethylethyl ester
- 中文名:
- tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate
- 中文別名:
- 1-BOC-3-(2-溴乙基)氮雜環(huán)丁烷;3-(2-溴乙基)氮雜環(huán)丁烷-1-羧酸叔丁酯
- CBNumber:
- CB93052845
- 分子式:
- C10H18BrNO2
- 分子量:
- 264.16
- MOL File:
- 1420859-80-8.mol
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tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate化學(xué)性質(zhì)
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沸點(diǎn):
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298.1±13.0 °C(Predicted)
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密度:
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1.320±0.06 g/cm3(Predicted)
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儲(chǔ)存條件:
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Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
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酸度系數(shù)(pKa):
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-1.68±0.40(Predicted)
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外觀:
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Colorless to light yellow Liquid
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InChI:
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InChI=1S/C10H18BrNO2/c1-10(2,3)14-9(13)12-6-8(7-12)4-5-11/h8H,4-7H2,1-3H3
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InChIKey:
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IMCAWEYWTGJUEH-UHFFFAOYSA-N
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SMILES:
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N1(C(OC(C)(C)C)=O)CC(CCBr)C1
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tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate性質(zhì)、用途與生產(chǎn)工藝
生產(chǎn)方法
以3-(2-羥乙基)氮雜環(huán)丁烷-1-甲酸叔丁酯為原料合成3-(2-溴乙基)氮雜環(huán)丁烷-1-羧酸叔丁酯的一般步驟：在0℃下，向3-(2-羥乙基)氮雜環(huán)丁烷-1-羧酸叔丁酯（6.1g，30.3mmol）的二氯甲烷（100mL）溶液中依次加入四溴化碳（19.8g，60.6mmol）和三苯基膦（15.7g，60.6mmol）。將反應(yīng)混合物在室溫下攪拌過夜。反應(yīng)完成后，濃縮混合物，殘余物通過硅膠柱色譜法（洗脫劑：石油醚/乙酸乙酯=100:1）純化，得到3-(2-溴乙基)氮雜環(huán)丁烷-1-羧酸叔丁酯（5.5g，產(chǎn)率69.4%），為無色油狀物。LC-MS m/z：208 [M+H-56]。
參考文獻(xiàn)：
[1] Patent: WO2017/27684, 2017, A1. Location in patent: Paragraph 00255
tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate
生產(chǎn)廠家
tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate 圖譜信息:
1420859-80-8, tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate 相關(guān)搜索:
- 吖啶類衍生物
- 1-BOC-3-(2-溴乙基)氮雜環(huán)丁烷
- 3-(2-溴乙基)氮雜環(huán)丁烷-1-羧酸叔丁酯
- 1420859-80-8
- 1-Boc-3-(2-bromoethyl)azetidine
- 3-(2-Bromo-ethyl)-azetidine-1-carboxylic acid tert-butyl ester
- 1-Azetidinecarboxylic acid, 3-(2-bromoethyl)-, 1,1-dimethylethyl ester
- tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate