1354707-41-7
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- CAS號:
- 1354707-41-7
- 英文名:
- Mitochonic acid 5
- 英文別名:
- Mitochonic acid;Mitochonic acid 5;Mitochonic acid 5(MA-5);Mitochonic acid 5, 10 mM in DMSO;α-[2-(2,4-Difluorophenyl)-2-oxoethyl]-1H-indole-3-acetic Acid;1H-Indole-3-acetic acid, α-[2-(2,4-difluorophenyl)-2-oxoethyl]-;MA5,Inhibitor,Mitochonic acid5,Mitochonic acid-5,Mitochondrial Metabolism,Mitochonic acid 5,inhibit,MA 5
- 中文名:
- 1354707-41-7
- 中文別名:
- 化合物MITOCHONIC ACID 5;4-(2,4-二氟苯基)-2-(1H-吲哚-3-基)-4-氧代丁酸;化合物MITOCHONIC ACID 5,10 MM DMSO 溶液
- CBNumber:
- CB94718636
- 分子式:
- C18H13F2NO3
- 分子量:
- 329.3
- MOL File:
- 1354707-41-7.mol
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1354707-41-7化學性質
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沸點:
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573.3±50.0 °C(Predicted)
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密度:
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1.426±0.06 g/cm3(Predicted)
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儲存條件:
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Store at -20°C
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溶解度:
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DMSO:106.66(Max Conc. mg/mL);323.9(Max Conc. mM)
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形態(tài):
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A solid
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酸度系數(shù)(pKa):
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4.52±0.37(Predicted)
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顏色:
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Light yellow to yellow
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InChI:
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1S/C18H13F2NO3/c19-10-5-6-12(15(20)7-10)17(22)8-13(18(23)24)14-9-21-16-4-2-1-3-11(14)16/h1-7,9,13,21H,8H2,(H,23,24)
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InChIKey:
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BOKQALWNGNLTOC-UHFFFAOYSA-N
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SMILES:
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OC(C(CC(C1=C(F)C=C(F)C=C1)=O)C2=CNC3=CC=CC=C32)=O
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1354707-41-7性質、用途與生產(chǎn)工藝
Mitochonic acid 5 (MA-5) 可通過上調 mitophagy 線粒體自噬來降低線粒體的凋亡。Mitochonic acid 5 可通過Bnip3和 MAPK-ERK-Yap 信號通路來調節(jié)線粒體自噬。Mitochonic acid 5 可調節(jié)線粒體的ATP的合成。
| Target | Value |
mitophagy
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Bnip3
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Mitochonic acid 5 (MA-5) modulates mitochondrial ATP synthesis independently of oxidative phosphorylation and the electron transport chain. Mitochondrial dysfunction causes increased oxidative stress and depletion of ATP, which are involved in the etiology of a variety of renal diseases. Mitochonic acid 5 (MA-5), which is derived from the plant growth hormone indole-3-acetic acid, can protect mitochondrial function by regulating energy metabolism and reducing mitochondrial oxidative stress. To observe the protective role of Mitochonic acid 5 in microglia under inflammatory conditions, TNFα is applied. Subsequently, the MTT assay is used to evaluate cell viability. In response to the TNFα treatment, cell viability significantly decreases. However, this effect is dose-dependently inhibited by Mitochonic acid 5 treatment.
Administration of Mitochonic acid 5 (MA-5) to an ischemia-reperfusion injury model and a cisplatin-induced nephropathy model improved renal function. To examine the tissue-protective effect of Mitochonic acid 5, the oral bioavailability is examined. Oral administration of Mitochonic acid 5 increases the plasma concentration in a dose-response manner at the peak time of 1 hour.
1354707-41-7
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
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| 2026/07/06 | S0881 | 1354707-41-7
Mitochonic acid 5 | 1354707-41-7 | 5mg | 1490.68元 |
| 2026/07/06 | S0881 | 1354707-41-7
Mitochonic acid 5 | 1354707-41-7 | 25mg | 4870.86元 |
1354707-41-7, 1354707-41-7 相關搜索:
- API
- 藥靶配體
- 抑制劑
- 化合物MITOCHONIC ACID 5,10 MM DMSO 溶液
- 化合物MITOCHONIC ACID 5
- 4-(2,4-二氟苯基)-2-(1H-吲哚-3-基)-4-氧代丁酸
- 1354707-41-7
- Mitochonic acid
- Mitochonic acid 5, 10 mM in DMSO
- MA5,Inhibitor,Mitochonic acid5,Mitochonic acid-5,Mitochondrial Metabolism,Mitochonic acid 5,inhibit,MA 5
- α-[2-(2,4-Difluorophenyl)-2-oxoethyl]-1H-indole-3-acetic Acid
- Mitochonic acid 5(MA-5)
- 1H-Indole-3-acetic acid, α-[2-(2,4-difluorophenyl)-2-oxoethyl]-
- Mitochonic acid 5