3-羧基地托咪定
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- CAS號:
- 115664-39-6
- 英文名:
- 3-(1H-IMIDAZOL-4-YLMETHYL)-2-METHYL-BENZOIC ACID
- 英文別名:
- 3-Carboxy DetoMidine;Detomidine carboxylic acid;detomidine 3-carboxylic acid;3-(1H-IMidazol-5-ylMethyl)-2-Methylbenzoic Acid;3-(1H-IMIDAZOL-4-YLMETHYL)-2-METHYL-BENZOIC ACID;Benzoic acid, 3-(1H-imidazol-5-ylmethyl)-2-methyl-
- 中文名:
- 3-羧基地托咪定
- 中文別名:
- 地托米定羧酸;3-羧基地托咪定
- CBNumber:
- CB9840865
- 分子式:
- C12H12N2O2
- 分子量:
- 216.24
- MOL File:
- 115664-39-6.mol
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3-羧基地托咪定化學性質
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沸點:
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499.6±33.0 °C(Predicted)
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密度:
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1.278±0.06 g/cm3(Predicted)
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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酸度系數(pKa):
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3.83±0.10(Predicted)
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形態(tài):
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Solid
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顏色:
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White to Pale Brown
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3-羧基地托咪定性質、用途與生產工藝
Detomidine carboxylic acid 是 Detomidine 的主要尿代謝產物。Detomidine 是一種合成的 α2-腎上腺素能 (α2-adrenergic) 激動劑，也是一種動物鎮(zhèn)痛鎮(zhèn)靜劑。Detomidine 還具有心臟和呼吸作用以及抗利尿作用。
Horse urine is investigated for metabolites following the oral administration of the large animal analgesic sedative Detomidine to two stallions and intravenous administration of [
3
H]-Detomidine to a mare. Detomidine carboxylic acid and hydroxydetomidine glucuronic acid conjugate are identified in the urine after the oral doses. About half of the radioactivity of [
3
H]-Detomidine is excreted in the urine in 12 h after the i.v. dose (80 μg/kg). Most of the excretion occurred between 5 and 12 h in contrast to urine output which is highest 2-5 h after the dosing. The major radioactive metabolite in the urine is Detomidine carboxylic acid. Detomidine carboxylic acid comprises more than two thirds of the total metabolites in all the urine fractions collected.
3-羧基地托咪定
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115664-39-6, 3-羧基地托咪定 相關搜索:
- Pharmaceuticals
- Metabolites & Impurities
- Intermediates & Fine Chemicals
- Heterocycles
- Aromatics
- Aromatics, Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
- 抑制劑
- 地托米定羧酸
- 3-羧基地托咪定
- 115664-39-6
- 3-Carboxy DetoMidine
- Benzoic acid, 3-(1H-imidazol-5-ylmethyl)-2-methyl-
- Detomidine carboxylic acid
- detomidine 3-carboxylic acid
- 3-(1H-IMIDAZOL-4-YLMETHYL)-2-METHYL-BENZOIC ACID
- 3-(1H-IMidazol-5-ylMethyl)-2-Methylbenzoic Acid