硫雄甾醇
|
|
|
- CAS號(hào):
- 2363-58-8
- 英文名:
- Epitiostanol
- 英文別名:
- 10275S;Thiodrol;NSC 194684;Epitiostano;Epitiostanol;EPitostsanol;Epithiostanol;Epitiostanol RS;Epithioandrostanol;Epitiostanol USP/EP/BP
- 中文名:
- 硫雄甾醇
- 中文別名:
- 硫雄甾醇;環(huán)硫雄醇
- CBNumber:
- CB9875137
- 分子式:
- C19H30OS
- 分子量:
- 306.51
- MOL File:
- 2363-58-8.mol
|
|
|
硫雄甾醇化學(xué)性質(zhì)
-
熔點(diǎn):
-
127-128°
-
|
-
比旋光度:
-
D27.5 +24.4° (c = 1.054 in chloroform)
-
|
-
沸點(diǎn):
-
417.1°C (rough estimate)
-
|
-
密度:
-
1.0122 (rough estimate)
-
|
-
折射率:
-
1.5700 (estimate)
-
|
-
溶解度:
-
Chloroform (Slightly), Methanol (Slightly)
-
|
-
形態(tài):
-
Solid
-
|
-
酸度系數(shù)(pKa):
-
15.10±0.60(Predicted)
-
|
-
顏色:
-
White to Off-White
-
|
-
水溶解性:
-
1.2mg/L(37 ºC)
-
|
硫雄甾醇性質(zhì)、用途與生產(chǎn)工藝
用途
硫雄甾醇的化學(xué)名為2α,3α-環(huán)硫-5α-雄甾17β-醇、環(huán)硫雄醇，具有抗雌激素、抗生育和明顯的抗癌活性，適用于乳腺癌，乳腺癥及女性化乳房等疾病的防治。
生產(chǎn)方法
由龍舌蘭制麻廢葉汁中提取的梯告吉寧所制得的表雄酮為起始原料，經(jīng)下列反應(yīng)合成硫雄甾醇。
參考文獻(xiàn)
[1] 李志達(dá),郭文璟,何長云.抗腫瘤藥環(huán)硫雄醇的合成[J].醫(yī)藥工業(yè),1983(10):1-3.DOI:10.16522/j.cnki.cjph.1983.10.001.
[2] 王中洲,鄭美鏗,潘秀森等.環(huán)硫雄醇對(duì)鼠生殖功能的影響[J].福建醫(yī)學(xué)院學(xué)報(bào),1988,(03):207-210.
[3] 林麗英,李志達(dá),陳振榮.抗腫瘤藥環(huán)硫雄醇衍生物的合成[J].福州大學(xué)學(xué)報(bào)(自然科學(xué)版),1987,(03):113-116.
硫雄甾醇
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
2363-58-8, 硫雄甾醇 相關(guān)搜索:
- Sulfur & Selenium Compounds
- Steroids
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Inhiitors
- C19H30OS
- 硫雄甾醇
- 環(huán)硫雄醇
- 2363-58-8
- Epitiostanol (Contains up to 15% 3Alpha,4Alpha-Epithioandrostan Isomer)
- Epitiostanol USP/EP/BP
- Epitiostanol RS
- Epitiostanol (Contains up to 15% 3α,4α-Epithioandrostan Isomer)
- EPitostsanol
- Epitiostano
- Androstan-17-ol,2,3-epithio-, (2a,3a,5a,17b)-
- (2α,3α,5α,17β)-2,3-Epithioandrostan-17-ol
- 2,3-Epithio-1H-cyclopenta[a]phenanthrene
- Thiodrol
- NSC 194684
- Epithiostanol
- Androstan-17-ol, 2,3-epithio-, (2α,3α,5α,17β)-
- 5α-Androstan-17β-ol, 2α,3α-epithio- (7CI, 8CI)
- 2α,3α-Epithio-5α-androstan-17β-ol
- 2,3-Epithio-1H-cyclopenta[a]phenanthrene, androstan-17-ol deriv.
- 10275S
- Epitiostanol
- Epithioandrostanol
- 2alpha,3alpha-Epithio-5alpha-androstan-17beta-ol