Vardenafil hydrochloride trihydrate
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- CAS-Nr.
- 330808-88-3
- Englisch Name:
- Vardenafil hydrochloride trihydrate
- Synonyma:
- VARDENAFIL HYDROCHLORIDE TRIHYDRATE;Vardenafil hydrochloride CRS;Vardenafil for system suitability;Vardenafil Hydrochloride (1711010);vardenafil hydrochloride trihyrate;Verdenafil Hydrochloride Trihydrate;Trihydrate of Hydrochloride Vardenafil;Vardenafil hydrochloride trihydrate, 10 mM in DMSO;2-(2-Ethoxy-5-((4-ethyl-piperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propyl-imidazo[5,1-f][1,2,4]triazin-4(1H)-one HCl hydrate;2-(2-ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one hydrochloride hydrate
- CBNumber:
- CB01230855
- Summenformel:
- C23H35ClN6O5S
- Molgewicht:
- 543.08
- MOL-Datei:
- 330808-88-3.mol
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Vardenafil hydrochloride trihydrate Eigenschaften
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- L?slichkeit
- ≥13.3 mg/mL in DMSO; ≥3.42 mg/mL in EtOH with gentle warming and ultrasonic; ≥95 mg/mL in H2O
- Aggregatzustand
- Solid
- Farbe
- White to off-white
- Major Application
- pharmaceutical (small molecule)
- InChIKey
- ACLSEHDEBRFBFC-UHFFFAOYSA-N
- SMILES
- C(C1=NC(C)=C2C(N=C(C3C=C(S(N4CCN(CC)CC4)(=O)=O)C=CC=3OCC)NN12)=O)CC.Cl.O
Vardenafil hydrochloride trihydrate Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Vardenafil is a potent inhibitor of phosphodiesterase 5 (PDE5; IC
50s = 0.2-1.2 nM) and PDE6 (IC
50 = 2 nM). It is selective for PDE5 and PDE6 over PDE1 and PDE11 (IC
50s = 230 and 130 nM, respectively). Vardenafil (4 mg/kg per day for three weeks) improves erectile function in a rat model of acute arteriogenic erectile dysfunction by increasing intracavernous pressure and mean arterial pressure, and this effect persists for at least two weeks following the end of treatment. Chronic vardenafil administration at a dose of 2 mg/kg for five weeks in subordinate mice reduces the latency to mount and increases the frequency of mounting behavior. Formulations containing vardenafil have been used in the treatment of erectile dysfunction.
Verwenden
Vardenafil hydrochloride trihydrate is a potent inhibitor of PDE5 (IC50 = 0.2-1.2 nM) that less effectively blocks the activities of PDE6, PDE1, and PDE11 (IC50s = 2, 230, and 130 nM, respectively). PDE5 inhibitors, including vardenafil, have applications in several conditions, including erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction.[Cayman Chemical]
Vardenafil hydrochloride trihydrate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Vardenafil hydrochloride trihydrate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 126)Lieferanten
- IMidazo[5,1-f][1,2,4]triazin-4(1H)-one,2-[2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-Methyl-7-propyl-,hydrochloride, hydrate (1:1:3)
- Vardenafil for system suitability
- Verdenafil Hydrochloride Trihydrate
- 2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one hydrochloride trihydrate
- vardenafil hydrochloride trihyrate
- Vardenafil Hydrochloride TrihydrateQ: What is
Vardenafil Hydrochloride Trihydrate Q: What is the CAS Number of
Vardenafil Hydrochloride Trihydrate Q: What is the storage condition of
Vardenafil Hydrochloride Trihydrate
- Vardenafil Hydrochloride (1711010)
- 2-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one,hydrochloride, hydrate (1:1:3)
- VARDENAFIL HYDROCHLORIDE TRIHYDRATE
- 2-(2-ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one hydrochloride hydrate
- Vardenafil hydrochloride trihydrate, 10 mM in DMSO
- 2-(2-Ethoxy-5-((4-ethyl-piperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propyl-imidazo[5,1-f][1,2,4]triazin-4(1H)-one HCl hydrate
- Vardenafil hydrochloride CRS
- Trihydrate of Hydrochloride Vardenafil
- 330808-88-3
