GW5074
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- CAS-Nr.
- 220904-83-6
- Englisch Name:
- GW5074
- Synonyma:
- W5074;GW5074;CS-399;GW5074, >=98%;GW-5074;GW 5074;GW5074 USP/EP/BP;GW 5074;GW-5074;GW5074;GW 5074, 10 mM in DMSO;RAF1 KINASE INHIBITOR I;GW5074, c-Raf1 kinase inhibitor
- CBNumber:
- CB0130215
- Summenformel:
- C15H8Br2INO2
- Molgewicht:
- 520.94
- MOL-Datei:
- 220904-83-6.mol
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GW5074 Eigenschaften
- Siedepunkt:
- 561.4±50.0 °C(Predicted)
- Dichte
- 2.248±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- L?slichkeit
- DMSO: soluble
- Aggregatzustand
- solid
- pka
- 5.86±0.25(Predicted)
- Farbe
- yellow to orange-brown
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
- InChI
- InChI=1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)
- InChIKey
- LMXYVLFTZRPNRV-XCVCLJGOSA-N
- SMILES
- N1C2=C(C=C(I)C=C2)C(=CC2=CC(Br)=C(O)C(Br)=C2)C1=O
- CAS Datenbank
- 220904-83-6
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| HS Code |
2933790090 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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GW5074 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
GW5074 has been used as a specific inhibitor of cRaf1 in C2 murine skeletal myoblasts, HT-29 colorectal adenocarcinoma cell line and neutrophils.
Biologische Aktivit?t
Potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC 50 = 9 nM). Displays ≥ 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm.
Biochem/physiol Actions
GW5074 is a cRaf1 kinase inhibitor, which is placed immediately downstream of Ras in the Motogen activated protein kinase (MAPK) signaling pathway. It elicits protection in GW5074 prevents degeneration in Huntington′s disease and also have therapeutic potential in treating neurodegenerative disorders. GW5074 in combination with anti-inflammatory drug, dexamethasone, attenuates sidestream smoke-induced airway inflammation.
GW5074 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
GW5074 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 191)Lieferanten
- RAF1 KINASE INHIBITOR I
- (3Z)-3-[(3,5-DIBROMO-4-HYDROXYPHENYL)METHYLIDENE]-5-IODO-1H-INDOL-2-ONE
- 5-IODO-3-[(3,5-DIBROMO-4-HYDROXYPHENYL)METHYLENE]-2-INDOLINONE
- 3-(3,5-DIBROMO-4-HYDROXY-BENZYLIDENE)-5-IODO-1,3-DIHYDRO-INDOL-2-ONE
- 3-(3,5-DIBROMO-4-HYDROXYBENZYLIDINE)-5-IODO-1,3-DIHYDRO-INDOL-2-ONE
- GW5074
- 2H-Indol-2-one, 3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo-
- 3-(3,5-dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one
- GW5074, >=98%
- (Z)-3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one
- GW-5074;GW 5074
- Raf1 Kinase Inhibitor I - CAS 220904-83-6 - Calbiochem
- GW 5074;GW-5074;GW5074
- CS-399
- W5074
- GW5074 USP/EP/BP
- 3-(3,5-Dibromo-4-hydroxybenzylidene)-5-iodo-2,3-dihydro-1H-indol-2-one
- 3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one
- (3E)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one
- GW5074, c-Raf1 kinase inhibitor
- GW 5074, 10 mM in DMSO
- 3-(3,5-dibromo-4-hydroxybenzenemethylene)-5-iodo-1,3-dihydroindole-2-one
- 220904-83-6
- 20904-83-6
- C15H8Br2INO2
- BioChemical
- Cell Signaling and Neuroscience
- Cell Biology
- Kinase/Phosphatase Biology
- Raf
- Serine/Threonine Kinase Inhibitors
- MAPK
- Inhibitors
