Aminopyridines Chemische Eigenschaften,Einsatz,Produktion Methoden
Biologische Funktion
The aminopyridines (4-aminopyridine; 3,4-diaminopyridine)
accelerate spontaneous exocytosis at central and
peripheral synapses. There is also an increase in the
number of transmitter quanta released by a nerve action
potential. This is probably the result of increased
Ca
++ inflow at the terminals due to a reduction of K
+
conductance and prolongation of the nerve action potential.
Muscle strength is increased in patients with the
Lambert-Eaton myasthenic syndrome and in others
poisoned with botulinum E toxin (discussed later).
Improvement in uncontrolled spasms, muscle tone, and
pulmonary function is noted in patients with multiple
sclerosis or long-standing spinal cord damage. Side effects
that limit clinical utility include convulsions, restlessness,
insomnia, and elevated blood pressure. Of the
two agents, 3,4-diaminopyridine is the more potent and
crosses the blood-brain barrier less readily.
Aminopyridines Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
