2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

In February 2013, the US FDA approved ospemifene (also referred to as FC1271a), for the treatment ofmoderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy (VVA), due tomenopause. It is estimated that there are 150 million postmenopausal women worldwide with 40–70% suffering from VVA. Ospemifene is a selective estrogen receptor (ER) modulator (SERM) and the first nonhormonal, nonestrogen for the treatment of moderate to severe dyspareunia in women with menopausal VVA. It binds to ERα (IC₅₀～800 nM) and ERβ (IC₅₀～1600 nM) with tissue-specific estrogenic agonist/antagonist effects. Treatment with ospemifene increases the thickness of the vaginal tissue thereby decreasing fragility of the tissue and reducing potential for pain during sexual intercourse.

Verwenden

Treatment of vaginal atrophy, osteoporosis, and vasomotor symptoms.

Definition

ChEBI: An organochlorine compound that is a selective estrogen receptor modulator; used for treatment of dyspareunia.

Clinical Use

Ospemifene is a SERM that is currently in Phase II/III clinical trials for the treatment of postmenopausal osteoporosis and urogenital atrophy. It is a known metabolite of toremifene, a triphenylethylene derivative used to treat breast cancer.Ospemifene has been shown to have beneficial effects on the bone without significant estrogen-related side effects. The beneficial effect observed on bone stems from this agent's ability to increase osteoblast proliferation and, as a result, to enhance bone mineralization as well as bone formation. Unlike tamoxifen, ospemifene does not induce osteocyte apoptosis.

2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10403	58
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	export01@shyrchem.com	CHINA	1319	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	28509	58
AFINE CHEMICALS LIMITED	+86-571-85134551	info@afinechem.com	China	15083	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9911	58
Guangzhou TongYi biochemistry technology Co.,LTD	+8613073028829	tongyibiochem@163.com	China	2995	58

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• 2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol
• 2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]-ethanol
• 2-(p-((Z)-4-Chloro-1,2-diphenyl-1-butenyl)phenoxy)ethanol
• Ccris 9205
• Fc-1271a
• Unii-B0p231ilbk
• Z-2-[4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy]ethanol
• 2-[4-[(Z)-4-chloro-1,2-diphenylbut-1-enyl]phenoxy]ethanol
• 2-(4-(4-chloro-1
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• Ospemifene FC-1271a
• Ethanol,2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]-
• CS-1039
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