HET0016
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- CAS-Nr.
- 339068-25-6
- Englisch Name:
- HET0016
- Synonyma:
- HET0016;HET0016,HET-0016;HET-0016, 20-HETE synthase inhibitor;N-Hydroxy-N(4-butyl-2-methylphenyl)formamidine;N-Hydroxy-N’-(4-butyl-2-methylphenyl)formamidine;N-HYDROXY-N'-(4-N-BUTYL-2-METHYLPHENYL)FORMANIDINE;N’-(4-Butyl-2-methylphenyl)-N-hydroxyformimidamide;N-(4-butyl-2-methylphenyl)-N'-hydroxyiminoformamide;N-(4-BUTYL-2-METHYLPHENYL)-N'-HYDROXY-METHANIMIDAMIDE;Methanimidamide, N'-(4-butyl-2-methylphenyl)-N-hydroxy-
- CBNumber:
- CB0149064
- Summenformel:
- C12H18N2O
- Molgewicht:
- 206.28
- MOL-Datei:
- 339068-25-6.mol
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HET0016 Eigenschaften
- Schmelzpunkt:
- 138-140°C
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- L?slichkeit
- Chloroform (Slightly), Ethanol (Slightly)
- Aggregatzustand
- Light pink solid.
- Farbe
- White to Pale Yellow
- InChI
- 1S/C12H18N2O/c1-3-4-5-11-6-7-12(10(2)8-11)13-9-14-15/h6-9,15H,3-5H2,1-2H3,(H,13,14)
- InChIKey
- LYNOGBKNFIHKLE-UHFFFAOYSA-N
- SMILES
- CCCCC1=CC=C(C(C)=C1)/N=C/NO
- CAS Datenbank
- 339068-25-6
HET0016 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
20-
HETE is a major biologically active cytochrome P450 (CYP450) metabolite of arachidonic acid in the kidney and liver. It regulates renal vascular and tubular functions as well as vascular tone in the cerebral circulation. HET0016 is an inhibitor of 20-
HETE formation in human renal microsomes with an IC
50 of 8.9 nM, selectively inhibiting CYP4A and 4F isoforms. HET0016 inhibits CYP2C9, CYP2D6, and CYP3A4, enzymes important in drug metabolism, significantly less effectively with IC
50s in the μM range. The IC
50 values for inhibition of cyclooxygenase and epoxyeicosatrienoic acids (EETs) formation are 2.3 and 2.8 μM, respectively.
Chemische Eigenschaften
Light Pink Solid
Verwenden
20-HETE is a major biologically active cytochrome P450 (CYP450) metabolite of arachidonic acid in the kidney and liver. It regulates renal vascular and tubular functions as well as vascular tone in the cerebral circulation. HET0016 is an inhibitor of 20-HETE formation in human renal microsomes with an IC50 of 8.9 nM, selectively inhibiting CYP4A and 4F isoforms. HET0016 inhibits CYP2C9, CYP2D6, and CYP3A4, enzymes important in drug metabolism, significantly less effectively with IC50s in the μM range. The IC50 values for inhibition of cyclooxygenase and epoxyeicosatrienoic acids (EETs) formation are 2.3 and 2.8 μM, respectively.[Cayman Chemical]
HET0016 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
HET0016 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 77)Lieferanten
339068-25-6()Verwandte Suche:
- HET0016
- N-HYDROXY-N'-(4-N-BUTYL-2-METHYLPHENYL)FORMANIDINE
- N-(4-BUTYL-2-METHYLPHENYL)-N'-HYDROXY-METHANIMIDAMIDE
- N-Hydroxy-N(4-butyl-2-methylphenyl)formamidine
- N-(4-butyl-2-methylphenyl)-N'-hydroxyiminoformamide
- N’-(4-Butyl-2-methylphenyl)-N-hydroxyformimidamide
- Methanimidamide, N'-(4-butyl-2-methylphenyl)-N-hydroxy-
- HET0016,HET-0016
- N-Hydroxy-N’-(4-butyl-2-methylphenyl)formamidine
- HET-0016, 20-HETE synthase inhibitor
- N-(4-buChemicalbooktyl-2-methylphenyl)-N'-hydroxyiminoformamide
- 339068-25-6
- Aromatics
