LAPAQUISTAT

189060-13-7

CAS-Nr.: 189060-13-7

Englisch Name:: LAPAQUISTAT

Synonyma:: TAK-475;CS-1400;LAPAQUISTAT;Lapaquistat Acetate;Lapaquistat Acetate (TAK-475);Lapaquistat and Lapaquistat Acetate;1-[[(3R,5S)-1-[3-(Acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-4-piperidineacetic acid;2-[1-[2-[1-(3-Acetoxy-2,2-diMethylpropyl)-7-chloro-5(S)-(2,3-diMethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3(R)-yl]acetyl]piperidin-4-yl]acetic acid;4-Piperidineacetic acid, 1-[2-[(3R,5S)-1-[3-(acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-;2-(1-(2-((3R,5S)-1-(3-Acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydrobenzo[e][1,4]oxazepin-3-yl)acetyl)piperidin-4-yl)acetic acid

CBNumber:: CB01509119

Summenformel:: C33H41ClN2O9

Molgewicht:: 645.14

MOL-Datei:: 189060-13-7.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 45

LAPAQUISTAT Eigenschaften

Schmelzpunkt:: 194-196℃

Siedepunkt:: 826.4±65.0 °C(Predicted)

Dichte: 1.246±0.06 g/cm3(Predicted)

storage temp.: Store at -20°C

L?slichkeit: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

pka: 4.66±0.10(Predicted)

Aggregatzustand: Solid

Farbe: White

InChIKey: CMLUGNQVANVZHY-POURPWNDSA-N

SMILES: O=C1[C@@H](CC(N2CCC(CC(O)=O)CC2)=O)O[C@H](C3=CC=CC(OC)=C3OC)C4=C(C=CC(Cl)=C4)N1CC(C)(C)COC(C)=O

Sicherheit

WGK Germany	WGK 3
Speicherklasse	11 - Combustible Solids

LAPAQUISTAT Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

A novel squalene synthase inhibitor. Lapaquistat acetate decreased plasma cholesterol and triglyceride levels, by lowering lipoproteins containing apoB100. Treatment with Lapaquistat acetate increased collagen concentration and transformed coronary plaques into fibromuscular plaques. Lapaquistat acetate also suppressed the expression of matrix metalloproteinase-1 and plasminogen activator inhibitor-1 in the plaque and increased peripheral coenzyme Q10 levels.Antiarteriosclerotics.

LAPAQUISTAT Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

LAPAQUISTAT Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 45)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Alfa Chemistry	+1-5166625404;	Info@alfa-chemistry.com	United States	20405	58
J & K SCIENTIFIC LTD.	18210857532; 18210857532	jkinfo@jkchemical.com	China	96815	76
ZHIWE CHEMTECH CO LTD	021-20221225 13917446399	zwchem@163.com	China	567	61
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2123	70
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15402	60
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 13167063860	anhua.mao@aladdin-e.com	China	29974	65
Wulechem Co., Ltd.	13761914825	wulesian@wulechem.com	China	285	58

LAPAQUISTAT
Lapaquistat and Lapaquistat Acetate
Lapaquistat Acetate
2-[1-[2-[1-(3-Acetoxy-2,2-diMethylpropyl)-7-chloro-5(S)-(2,3-diMethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3(R)-yl]acetyl]piperidin-4-yl]acetic acid
1-[[(3R,5S)-1-[3-(Acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-4-piperidineacetic acid
CS-1400
Lapaquistat Acetate (TAK-475)
4-Piperidineacetic acid, 1-[2-[(3R,5S)-1-[3-(acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-
2-(1-(2-((3R,5S)-1-(3-Acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydrobenzo[e][1,4]oxazepin-3-yl)acetyl)piperidin-4-yl)acetic acid
TAK-475
189060-13-7
C33H41ClN2O9
Amines
Chiral Reagents
Heterocycles
Inhibitors
Intermediates & Fine Chemicals
Pharmaceuticals

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