Colforsin
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- CAS-Nr.
- 66575-29-9
- Bezeichnung:
- Colforsin
- Englisch Name:
- Forskolin
- Synonyma:
- COLFORSIN;Coleus Forskolin;Forsklin;FORSKOHLIN;HL 362;CS-736;COLEONOL;Boforsin;ForsLean;FORSKOLIN
- CBNumber:
- CB0167677
- Summenformel:
- C22H34O7
- Molgewicht:
- 410.5
- MOL-Datei:
- 66575-29-9.mol
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Colforsin Eigenschaften
- Schmelzpunkt:
- 282-232 °C
- Siedepunkt:
- 520℃
- alpha
- D25 -26.19° (c = 1.68 in CHCl3)
- Dichte
- 1.23
- Brechungsindex
- 1.5300 (estimate)
- Flammpunkt:
- 172℃
- storage temp.
- room temp
- L?slichkeit
- DMSO: 5 mg/mL stable at least 6 months at room temperature
- Aggregatzustand
- powder
- pka
- 11.00±0.70(Predicted)
- Farbe
- off-white
- Biologische Quelle
- Coleus forskohlii
- Wasserl?slichkeit
- Soluble in ethanol, dimethylsulfoxide and chloroform. Insolule in water.
- maximale Wellenl?nge (λmax)
- 305nm(lit.)
- Merck
- 14,2476
- BRN
- 1692716
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.
- Major Application
- food and beverages
- InChIKey
- OHCQJHSOBUTRHG-KGGHGJDLSA-N
- SMILES
- CC(=O)O[C@H]1[C@@H](O)[C@H]2C(C)(C)CC[C@H](O)[C@]2(C)[C@@]3(O)C(=O)C[C@@](C)(O[C@]13C)C=C
- LogP
- 2.406 (est)
- CAS Datenbank
- 66575-29-9
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
21 |
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| S-S?tze: |
22-36/37 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
QL6150000 |
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| F |
10-21 |
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| HS Code |
29329990 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Acute Tox. 4 Dermal |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H312 |
Gesundheitssch?dlich bei Hautkontakt. |
Akute Toxizit?t dermal |
Kategorie 4 |
Warnung |
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P280,P302+P352, P312, P322, P363,P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Colforsin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R21:Gesundheitssch?dlich bei Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Chemische Eigenschaften
Colorless Crystalline Solid
Verwenden
Forskolin is a diterpene isolated from Coleus forskohlii, possessing vasodilating and cardiostimulatory properties. Forskolin resensitizes cell receptors by activating the enzyme adenylyl cyclase and increasing the intracellular levels of cAMP.
Allgemeine Beschreibung
Forskolin, present predominantly in the root of
Coleus forskohlii plant, is a potential pharmacological compound. It is used for treating hypertension, respiratory disorders and obesity. Forskolin is a diterpenoid capable of modulating adenylate cyclase enzyme and cyclic adenosine monophosphate (cAMP) levels. Engineering forskolin biosynthetic pathway caters its commercial production for pharmacological use. Forskolin has antioxidant and anti-inflammatory property and reduces hyperglycemia by stimulating insulin release. Forskolin promotes differentiation of hepatoma HepaRG cells and activates farnesoid X receptor (FXR) and pregnane X receptor(PXR).
Biologische Aktivit?t
Cell-permeable activator of adenylyl cyclase. Hypotensive and vasodilatory agent. Induces neuronal differentiation in stem cells and in several neuroblastoma. Also available as part of the PKA Tocriset™ .
l?uterung methode
It is an antihypertensive, a positive ionotropic, a platelet aggregation inhibitor, and it has adenylate cyclase activating properties [Chem Abstr 89 244150 1978, de Souza et al. Med Res Rev 3 201 1983, X-ray: Tandon et al. Indian J Chem 15B 880 1977]. [Beilstein 18/5 V 55.]
Colforsin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Essigs?ureanhydrid
1ALPHA,6BETA,7BETA,9ALPHA-TETRAHYDROXY-8,13-EPOXY-LABD-14-EN-11-ONE
7H-1,3-Dioxolo[3,4]naphtho[2,1-b]pyran-7-one, 5-ethenyldodecahydro-8-hydroxy-2,2,3b,5,7b,11,11-heptamethyl-, (3aS,3bS,5R,7aR,7bS,8S,11aS,11bS)-
Downstream Produkte
Colforsin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 541)Lieferanten
66575-29-9(Colforsin)Verwandte Suche:
1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylen-7,14-dion
4-Isopropenylcyclohex-1-en-1-ylmethanol
Colforsin
- 7BETA-ACETOXY-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-8,13-EPOXY-LABD-14-EN-11-ONE
- 7BETA-ACETOXY-8,13-EPOXY-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-EN-11-ONE
- 7BETA-ACETOXY-8,13-EPOXY-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-ENE-11-ONE
- [3R-(3A,4AB,5B,6B,6AA,10A,10AB,10BA)]-5-(ACETYLOXY)-3-ETHENYLDODECAHYDRO-6,10,10B-TRIHYDROXY-3,4A,7,7,10A-PENTAMETHYL-1H-NAPHTHO[2,1-B]PYRAN-1-ONE
- 10a-beta,10b-alpha))-10-alph
- 1-b)pyran-1-one,dodecahydro-5-(acetyloxy)-3-ethenyl-3,4a,7,7,10a-1h-naphtho(
- pentamethyl-6,10,10b-trihydroxy-,(3r-(3-alpha,4a-beta,5-beta,6-beta,6a-alpha,
- FORSKOLIN FROM COLEUS FORSKOHLII
- FORSKOLIN, MOLECULAR BIOLOGY REAGENT
- FORSKOLIN 98+%
- FORSKOLIN, 99+%
- 1H-Naphtho[2,1-b]pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-
- Forskolin ForsLean Colforsin HL 362 NSC 357088 NSC 375489
- BETA-ACETOXY-8,13-EPOXY-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-EN-11-ONE
- FORSKOLIN
- FORSKOLIN, COLEUS FORSKOHLII
- COLEONOL
- (3R,4AR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldod
- Boforsin
- (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-Naphtho[2,1-b]pyran-1-one
- ForsLean
- HL 362
- L 75-1362B
- NSC 35708
- 7β-acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one
- Forskolin, Colforsin, Coleonol
- FORMYL-O-BENZYL-L-SERINE
- Coleonol, Colforsin
- (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-Naphtho[2,1-β]pyran-1-one
- NSC 357088
- 7SS-ACETOXY-8,13-EPOXY-1ALPHA,6SS,9ALPHA-TRIHYDROXYLABD-14-EN-11-ONE
- Coleonol, Colforsin, 7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one
- Colforsin, Boforsin
- [3R-(3alpha,4abeta,5beta,6beta,6aalpha,10alpha,10abeta,10betaalpha)]-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
- (3R,6aα)-5β-Acetoxy-3α-ethenyldodecahydro-6β,10α,10bα-trihydroxy-3,4aβ,7,7,10aβ-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
- 7-Acetoxy-8,13-epoxy-1alpha,6,9alpha-trihydroxylabd-14-en-11-one
- 7β-Acetoxy-8,23-epoxy-1 α
- ForskolinColforsin
- [3R-(3α,4aβ,5β,6β,6aα,10α,10aβ,10bα)]-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
- NSC 375489
- Forskolin (40 mg) (7Beta-acetoxy-8,13-epoxy-1alpha,6Beta,9alpha-trihydroxy-labd-14-en-11-one)
- Forskolii
- Coleus forskohlii(Willd.)Briq.
- Forskolin, 98%, from Coleus forskohlii
- Forskolin (plant extract)
- Forskolin ( Coleus Forskohlii extract)
- Forskolin - Coleonol
- CS-736
- Forskolin, Coleus forskohlii - CAS 66575-29-9 - Calbiochem
- Forskolin >
- (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-1H-benzo[f]chromen-5-yl acetate
- Forskolin, ≥98% (HPLC), powder
- 2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOL
- Forskolin supplier in China
- Colforsin (Forskolin, HL 362)
- Forskolin, Adenylyl cyclase activator
- Forskolin, 10 mM in DMSO
- Forskolin, Coleus forskohlii
