Bimatoprost Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Bimatoprost was first introduced in the US and Brazil as Lumigan, an ophthalmic solution (0.03%) for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension, a proven risk of glaucomatous visual field loss. Bitamoprost is a new agent belonging to the PGF_2α analog class of prostamides launched in this indication after latanoprost, the most efficaceous topical medication currently available. This synthetic fatty acid amide can be prepared by esterification of 17- phenyl-18,19,20-trinorprostaglandin F_2α followed by ethylamidation. Bimatoprost, as related prostamides, is devoid of typical activities associated with PGF2,, analogs; it exhibits a unique pharmacological profile in contracting the feline iris sphincter with an EC₅₀ of 34 nM without interacting with any known prostanoid receptors. Thus it mimics the action of endogenous prostamides on specific receptors that lower IOP by increasing aqueous humor outflow through both pressure-insensitive and pressure-sensitive pathways without reducing humor formation. In a 3-month controlled clinical trial of efficacy and safety in patients with elevated IOP, bimatoprost demonstrated lower mean intraocular pressures at every time point throughout the study, as well as a good tolerance and systemic safety profile compared to latanoprost.

Chemische Eigenschaften

Crystalline Solid

Verwenden

Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. It reduces intraocular pressure (IOP) by increasing the outflow of aqueous fluid from the eyes. It ha

Allgemeine Beschreibung

Bimatoprost (Lumigan) is supplied as a sterile 0.03%ophthalmic solution in 2.5- and 5.0-mL sizes. The recommendeddosage of bimatoprost is limited to one drop intothe affected eye once daily in the evening. Increased usagemay decrease its beneficial effect. If used concurrently withother IOP-lowering drugs, a waiting period of 5 minutesshould separate administrations.

Bimatoprost Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Bimatoprost Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21586	55
Shenzhen Monkono Technology Co.,Ltd	+86-17063441314	sansbiotech@outlook.com	China	677	58
Hangzhou Hyper Chemicals Limited	+86-0086-57187702781 +8613675893055	info@hyper-chem.com	China	310	58
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.	+86-029-86333380 +86-18829239519	sales06@tgybio.com	China	898	58
Xi an Biohorlden Industry Trade Co Ltd	+86-18829283179 +86-13636819721	sales@horlden.com	China	334	58
Shaanxi Dideu Medichem Co. Ltd	+8617392709771	1097@dideu.com	China	3992	58
Hebei Dangtong Import and export Co LTD	+86-86-4001020630 +8619831957301	admin@hbdangtong.com	China	1000	58
Guangzhou Tengyue Chemical Co., Ltd.	+86-86-18148706580 +8618826483838	evan@tyvovo.com	China	143	58
airuikechemical co., ltd.	+86-18353166132	sales02@airuikechemical.com	China	983	58
BINBO BIOLOGICAL CO.,LTD	+8618629063126	info@binbobiological.com	China	477	58

155206-00-1()Verwandte Suche:

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• BIMATOPROST
• BIMATOPROST(TM)
• BIMATOPROST(LUMIGAN)
• Prostamide
• 17-phenyl-tri-norprostaglandin f2α-ethyl a
• cGMP Bimatoprost
• BiMapnost
• (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl]-N-ethylhept-5-enaMide
• Bimatoprost, >=99.5%
• 17-Phenyl-tri-norprostaglandin F2a-ethyl aMide
• (Z)-7-((1R,2R,3S,5S)-3,5-dihydroxy-2-((E)-3-hydroxy-5-phenylpent-1-enyl)cyclopentyl)-N-ethylhept-5-enamide
• (Z)-7-((1R,2R,3S,5S)-3,5-Dihydroxy-2-((S,E)-3-hydroxy-5-phenylpent-1-enyl)cyclopentyl)-N-ethyl
• Bimatoprost API
• Bimatoprost CAS NO.155206-00-1
• buprostaglandin
• Beme Prostaglandin
• CS-2897
• 5-Heptenamide, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-N-ethyl-, (5Z)-
• 17-Phenyltrinor-PGF2alpha Ethylamide
• (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(S,E)-3-hydroxy-5-phenylpent-1-en-1-yl]cyclopentyl]-N-ethylhept-5-enamide
• Bimatoprost USP/EP/BP
• (Z)-7-[(1S,2S,3R,5R)-3,5-Dihydroxy-2-[(E)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N-ethylhept-5-enamide
• Bimatoprost CAS 155206 00 1
• Bimatoprost (AGN 192024)
• BimatoprostQ: What is Bimatoprost Q: What is the CAS Number of Bimatoprost Q: What is the storage condition of Bimatoprost Q: What are the applications of Bimatoprost
• N-ETHYL-9ALPHA,11ALPHA,15S-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROSTA-5Z, 13E-DIEN-1-AMIDE
• 17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ETHYL AMIDE
• bimatoprost powder
• bimatopros
• 6-Amino-2,4-dichloro-6-methylphenol&hydrochloride
• 17-phenyl-tri-norprostaglandin f2α-ethyl amide
• BiMatoprost HOUSE STANDARD
• Bimatoprost (W.S)
• Bimalprostone
• Bimatoprost-1
• (E)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3- hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N-ethylhept-5-enamide
• Bimatoprost Reference Standard
• Bisoprostol
• Bimatoprost CAS
• Hydroxy-5-Phenylpent-1-Enyl]Cyclopentyl]-N-Ethylhept-5-
• Bemeprost
• Bimatoprost, 10 mM in DMSO
• 17-Phenyl-tri-norprostaglandin F_2α-ethyl amide
• GMP Bimatoprost
• D5-Bimatoprost
• (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-5-phenylpentyl-1-ene-1-yl)cyclopentyl)-N-ethylheptyl-5-eneamide
• Bimatoprost (Standard)
• (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-N-ethyl-5-heptenamide
• (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N-ethylhept-5-enamide
• Bima
• LUMIGAN
• 155206-00-1
• 206-00-1
• Prostaglandin
• Chiral Reagents
• Intermediates & Fine Chemicals
• Pharmaceuticals
• Arachidonic Acid Cascade