2,6-Diamino-1H-pyrimidin-4-on
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- CAS-Nr.
- 56-06-4
- Bezeichnung:
- 2,6-Diamino-1H-pyrimidin-4-on
- Englisch Name:
- 2,4-Diamino-6-hydroxypyrimidine
- Synonyma:
- 2,6-DIAMINOPYRIMIDIN-4-OL;1956-6-4;DAHP;2,6-Diaminopyrimidin-4(1H)-one;2,6-DIAMINO-4-PYRIMIDINOL;2,6-diamino-1H-pyrimidin-4-one;2,6-DIAMINO-4-HYDROXYPYRIMIDINE;4(3H)-pyrimidinone, 2,6-diamino-;9-60-9;NSC 9302
- CBNumber:
- CB0174912
- Summenformel:
- C4H6N4O
- Molgewicht:
- 126.12
- MOL-Datei:
- 56-06-4.mol
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2,6-Diamino-1H-pyrimidin-4-on Eigenschaften
- Schmelzpunkt:
- 285-286 °C (dec.) (lit.)
- Siedepunkt:
- 234.22°C (rough estimate)
- Dichte
- 1.3659 (rough estimate)
- Brechungsindex
- 1.7990 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- pka
- 10.61±0.50(Predicted)
- Aggregatzustand
- Fine Crystalline Powder
- Farbe
- White to cream
- Sensitive
- Light Sensitive
- Merck
- 14,2981
- BRN
- 125006
- InChIKey
- SWELIMKTDYHAOY-UHFFFAOYSA-N
- CAS Datenbank
- 56-06-4(CAS DataBase Reference)
- NIST chemische Informationen
- 4(1H)-pyrimidinone, 2,6-diamino-(56-06-4)
- EPA chemische Informationen
- 2,6-Diamino-4(1H)-pyrimidinone (56-06-4)
2,6-Diamino-1H-pyrimidin-4-on Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
2,4-
Diamino-
6-
hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for
de novo pterin synthesis. In HUVEC cells, the IC
50 for inhibition of BH
4 biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.
Chemische Eigenschaften
White Solid
Verwenden
2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC50 for inhibition of BH4 biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.[Cayman Chemical]
Synthese
A solution of sodium ethoxide is prepared from 23 g. (1 g. atom) of sodium and 250 ml of anhydrous ethanol in a 1-l round-bottomed flask fitted with a reflux condenser carrying a calcium chloride drying tube. After the sodium has dissolved, the solution is cooled and 113 g. (1 mole) of ethyl cyanoacetate is added. This mixture is allowed to stand while a second solution of sodium ethoxide of the same volume and concentration is prepared. To this solution is added 97 g. (1.02 moles) of guanidine hydrochloride. The sodium chloride is separated by filtration, and the clear filtrate containing guanidine is added to the solution of ethyl sodiocyanoacetate. This mixture is heated for 2 hours under reflux and is then evaporated to dryness at atmospheric pressure. The solid product is dissolved in 325 ml. of boiling water and acidified with 67 ml. of glacial acetic acid. Upon cooling of the solution, 101–103 g. (80–82%) of yellow needles separates; m.p. 260–270° (dec.)
l?uterung methode
2,4-Diamino-6-hydroxypyrimidine recrystallises from H2O. [Beilstein 25 III/IV 3642.]
2,6-Diamino-1H-pyrimidin-4-on Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2,6-Diamino-1H-pyrimidin-4-on Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 582)Lieferanten
56-06-4(2,6-Diamino-1H-pyrimidin-4-on)Verwandte Suche:
- 2,4-Diamino-6-hydroxypyrimidine,96%
- TIMTEC-BB SBB004252
- 2,4-DIAMINOPYRIMIDIN-6-OL
- 2,4-DIAMINO-6-HYDROXYPYRIMIDINE
- 2,4-DIAMINO-6-PYRIMIDINOL
- 2,4-DIAMINO-6(1H)-PYRIMIDINONE
- 2,6-DIAMINO-4-PYRIMIDINONE
- 2,6-DIAMINO-4(1H)-PYRIMIDINONE
- AURORA KA-376
- AKOS MSC-0109
- 2,6-Diamino-4-Hydroxyprimidine
- 2-4-DIAMINO6HYDROXY PYRIMID
- 2,4- two-6- aMinohydroxy pyriMidine
- 2,4-DiaMino-6-hydroxypyriMidine 96%
- 2,4-DiaMino-6-hydroxypyriMidine, 97+%
- InChI=1/C4H6N4O/c5-2-1-3(9)8-4(6)7-2/h1H,(H5,5,6,7,8,9
- 2,4-Diamino-6-hydroxypyrimidiine
- 4(1H)-Pyrimidinone, 2,6-diamino- (8CI,9CI)
- 2,6-Diaminopyrimidin-4-one
- 6-Aminoisocytosine
- NSC 44914
- NSC 680818
- NSC 9302
- 2,4-Diamino-6-hydroxy
- 2,4-diaminohypoxanthine
- 2,6-Diamino-1H-pyrimidin-4-on
- 2,4-Diamino-6. -Hydroxypyimidine
- 2,6-DIAMINO-3H-PYRIMIDIN-4-ONE
- 4(1H)-Pyrimidinone, 2,6-diamino
- 2,4-Diamino-6-hydroxypyrimidine, 2,6-Diamino-4-pyrimidinol, 2,6-Diamino-4-pyrimidinone
- 2,4-Diamino-6-hydroxypyrimidine, 2,6-Diamino-4-pyrimidinol
- 2,4-Diamino-6-pyrimidinone
- 2,6-Diamino-3,4-dihydropyrimidine-4-one
- 2,6-Diamino-4(3H)-pyrimidinone
- 2,4-Diamino-6-hydroxypyrimidine,2,4-Diamino-6-hydroxypyrimidine, 2,6-Diamino-4-pyrimidinol, 2,6-Diamino-4-pyrimidinone
- 4-DiaMino-6-hydroxypyriMidine
- 2,4-DIAMINO-6-HYDROXYPYRIDIMIDINE
- 6-Hydroxy-2,4-diaminopyrimidine
- 2,4-Diamino-6-hydroxypyrimidine >
- 2,4-Diamino-6-hydroxypyrimidine ISO 9001：2015 REACH
- 2,4-Diamino-6-hydroxypyrimidine,56-06-4
- NSC 18522
- NSC18522
- NSC-18522
- 3-methylidene-1,5-benzodioxepine
- Pemetrexed Impurity 16
- DAHP
- 2,6-diamino-1H-pyrimidin-4-one
- 4(3H)-pyrimidinone, 2,6-diamino-
- 2,6-Diaminopyrimidin-4(1H)-one
- 1956-6-4
- Minoxidil Impurity 19
- 2,6-DIAMINO-4-PYRIMIDINOL
- 2,6-DIAMINO-4-HYDROXYPYRIMIDINE
- 2,4-Diamino-6-hydroxypyrimidine(98.60%)
- 9-60-9
- 2.4-Diamino-6-pyrimidone
- 2,4-Diamino-6-pyrimidone in Acetonitrile:Methanol=8:2
