6-O-Methyl-guanine
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- CAS-Nr.
- 20535-83-5
- Englisch Name:
- 6-O-Methyl-guanine
- Synonyma:
- 6-methoxy-9h-purin-2-amine;6-Methoxyguanine;6-Methoxy-7H-purin-2-amine;NSC 37364;O-METHYLGUANINE;O6-METHYLGUANINE;6-O-Methylguanine;o(sup6)-methylguanine;6-O-Methylguanine 97%;Aminomethoxypurine,97%
- CBNumber:
- CB0177812
- Summenformel:
- C6H7N5O
- Molgewicht:
- 165.15
- MOL-Datei:
- 20535-83-5.mol
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6-O-Methyl-guanine Eigenschaften
- Schmelzpunkt:
- >300 °C(lit.)
- Siedepunkt:
- 598.5±53.0 °C(Predicted)
- Dichte
- 1.531±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- L?slichkeit
- DMSO (Slightly, Heated), Water (Slightly, Heated)
- Aggregatzustand
- Solid
- pka
- 9.74±0.10(Predicted)
- Farbe
- Off-White to Pale Yellow
- BRN
- 645384
- InChI
- InChI=1S/C6H7N5O/c1-12-5-3-4(9-2-8-3)10-6(7)11-5/h2H,1H3,(H3,7,8,9,10,11)
- InChIKey
- BXJHWYVXLGLDMZ-UHFFFAOYSA-N
- SMILES
- N1C2C(=NC(N)=NC=2OC)NC=1
- CAS Datenbank
- 20535-83-5(CAS DataBase Reference)
6-O-Methyl-guanine Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Off-white solid
Verwenden
Antitumor agent
Definition
ChEBI: A methylguanine in which the methyl group is positioned on the oxygen at position 6. Formed in DNA by alkylation of the oxygen atom of guanine, most often by N-nitroso compounds and sometimes due to methylation by other compounds such as
endogenous S-adenosylmethionine, it base-pairs to thymine rather than cytidine, causing a G:C to A:T transition in DNA.
Application
6-O-Methyl-guanine is a key molecular tool for studying DNA damage, repair mechanisms, and cancer chemotherapy. It is a potent mutagenic and carcinogenic DNA damage product induced by alkylating agents (such as certain environmental carcinogens and chemotherapeutic drugs). It can mispair with thymine (T), leading to G:C to A:T base transition mutations during DNA replication. Therefore, O?-MeG is widely used in in vitro and cellular experiments to simulate DNA damage states and study how cells remove this damage through repair proteins such as O?-methylguanine-DNA methyltransferase (MGMT).
Allgemeine Beschreibung
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
6-O-Methyl-guanine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
6-O-Methyl-guanine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 246)Lieferanten
20535-83-5()Verwandte Suche:
- O6-METHYLGUANINE
- O-METHYLGUANINE
- 2-amino-6-methoxy-purin
- 6-methoxy-1h-purin-2-amin
- 6-methoxy-1h-purine-2-amine
- o(sup6)-methylguanine
- 6-methoxy-1h-purin-2-amine
- 2-AMINO-6-METHOXYPURINE
- 6-O-Methylguanine
- Aminomethoxypurine,97%
- 2-Amino-6-methoxy-9H-purine
- 2-AMINO-6-METHOXYPURINE 97+%
- NSC 37364
- 2-Amino-6-methoxypurine, 6-Methoxyguanine
- 6-O-Methylguanine,2-Amino-6-methoxypurine, 6-Methoxyguanine
- 6-Methoxy-9H-purin-2-ylaMine
- 6-O-Methylguanine 97%
- 6-O-Methylguanine (2-Amino-6-Methoxypurine)
- 6-O-Methylguanine, 97 %
- 2-Amino-6-methoxypurine >
- 9H-Purin-2-amine, 6-methoxy-
- 6-Methoxyguanine USP/EP/BP
- 2-amino-6-methoxypuryne
- Nelarabine Impurity 11
- 6-O-Methylguanine
- Methyl guanine impurity
- 6-Methoxy-7H-purin-2-amine
- 6-methoxy-9h-purin-2-amine
- 6-Methoxyguanine
- 20535-83-5
- 205350-83-5
- Building Blocks
- Heterocyclic Building Blocks
- Purines
- Bases & Related Reagents
- Intermediates & Fine Chemicals
- Nucleotides
- Pharmaceuticals
- Fused Ring Systems
- Amines
- Purine
- Intermediate in the synthesis of Tropine and respective derivatives
- Chemical Amines
- Purines
