NVP-BEZ 235
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- CAS-Nr.
- 915019-65-7
- Englisch Name:
- NVP-BEZ 235
- Synonyma:
- Dactolisib;104794;CS-381;BEZ-235;RTB-101;NVP-BEZ 235;BEZ235 0.6G;BEZ235, >=98%;NVP-BEZ235-NX;NVP-BEZ235-ANA
- CBNumber:
- CB01872365
- Summenformel:
- C30H23N5O
- Molgewicht:
- 469.55
- MOL-Datei:
- 915019-65-7.mol
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NVP-BEZ 235 Eigenschaften
- Schmelzpunkt:
- 288-289°C
- Siedepunkt:
- 701.0±70.0 °C(Predicted)
- Dichte
- 1.299
- storage temp.
- Refrigerator
- L?slichkeit
- Soluble in DMSO (up to 1 mg/ml with warming) or in DMF (up to 10 mg/ml, dissolves slowly, requires heating to 75C).
- Aggregatzustand
- White powder.
- pka
- 6.41±0.20(Predicted)
- Farbe
- White or off-white
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 1 month.
- InChI
- InChI=1S/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3
- InChIKey
- JOGKUKXHTYWRGZ-UHFFFAOYSA-N
- SMILES
- O=C1N(C2C=NC3=CC=C(C4C=NC5C=CC=CC=5C=4)C=C3C=2N1C1C=CC(C(C)(C)C#N)=CC=1)C
- CAS Datenbank
- 915019-65-7
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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NVP-BEZ 235 Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Light Beige Solid
Verwenden
Inhibitor of phosphatidylinositol 3-kinases, P13K and mTOR.
Definition
ChEBI: An imidazoquinoline that is 3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinoline substituted at position 1 by a 4-(1-cyanoisopropyl)phenyl group and at position 8 by a quinolin-3-yl group. A dual PI3K/mTOR inhibitor used in
cancer treatment.
in vivo
BEZ235 induced tumor regression (69%) without a statistically significant effect on weight gain. Taken together, these preliminary in vivo efficacy findings suggest that BEZ235 blocks disease progression when administered orally alone and enhances efficacy when combined with other anticancer drugs.
NVP-BEZ 235 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
NVP-BEZ 235 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 266)Lieferanten
915019-65-7()Verwandte Suche:
- 4-[2,3-Dihydro-3-Methyl-2-oxo-8-(quinolin-3-yl)-1H-iMidazo[4,5-c]quinolin-1-yl]-alpha,alpha-diMethylbenzeneacetonitrile
- BEZ-235
- 2-methyl-2-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)propanenitrile
- 2-Methyl-2-[3-Methyl-2-oxo-8-(3-quinolinyl)-1-iMidazo[4,5-c]quinolinyl]propanenitrile
- BEZ235 (NVP-BEZ235, Dactolisib)
- 2-Methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl
- BEZ235 NVP-BEZ235(BEZ235)
- 2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile BEZ235(NVP-BEZ235)
- NVP-BEZ 235
2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile
- Benzeneacetonitrile, 4-[2,3-dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-.alpha.,.alpha.-dimethyl-
- 4-[2,3-Dihydro-3-Methyl-2-oxo-8-(3-quinolinyl)-1H-iMidazo[4,5-c]quinolin-1-yl]-α,α-diMethyl-benzeneacetonitrile
- NVP-BEZ235(BEZ235)
- BEZ235, >=98%
- BEZ-235 (Dactolisib)
- 2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile Dactolisib
- 2-Methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phe
- NVP-BEZ 235
- 2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile
- 2-methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile
- BEZ235 0.6G
- BEZ235 (NVP-BEZ235)
- 104794
- Dactolisib (BEZ235, NVP-BEZ235)
- CS-381
- Dactolisib (BEZ235)
- NVP-BEZ235(Dactolisib
- NVP-BEZ 235;BEZ-235;BEZ 235;NVP-BEZ235;DACTOLISIB
- Benzeneacetonitrile, 4-[2,3-dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-α,α-dimethyl-
- NVP-BEZ 235 USP/EP/BP
- TIANFU-CHEM BEZ235 (NVP-BEZ235, Dactolisib)
- Dactolisib(NVP-BEZ 235)
- 4-2,3-Dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo4,5-cquinolin-1-yl-.alpha.,.alpha.-dimethyl-benzeneacetonitrile
- NVP-BEZ235, PI3K and mTOR inhibitor
- NVP-BEZ235 Base
- NVP-BEZ235-ANA
- NVP-BEZ235-NX
- RTB-101
- Dactolisib
- 915019-65-7
- 5019-65-7
- C30H23N5O
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Protein Kinase Inhibitors and Activators
- api
- Inhibitors
- Akt
- mTOR
- PI3K
