LUFFARIELLOLIDE

111149-87-2

CAS-Nr.: 111149-87-2

Englisch Name:: LUFFARIELLOLIDE

Synonyma:: LUFFARIELLOLIDE;Luffariellolide, phospholipase A2 (PLA2) inhibitor. Agonist at RARalpha;3-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohexen-1-yl)deca-3,7-dienyl]-2-hydroxy-2H-furan-5-one;4-[(3E,7E)-4,8-Dimethyl-10-(2,6,6-trimethyl-1-cyclohexenyl)-3,7-decadienyl]-5-hydroxyfuran-2(5H)-one;4-[(3E,7E)-4,8-Dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadienyl]-5-hydroxy-2(5H)-furanone;2(5H)-Furanone, 4-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadien-1-yl]-5-hydroxy-

CBNumber:: CB0200705

Summenformel:: C25H38O3

Molgewicht:: 386.57

MOL-Datei:: 111149-87-2.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 48

LUFFARIELLOLIDE Eigenschaften

Siedepunkt:: 541.7±50.0 °C(Predicted)

Dichte: 1.006±0.06 g/cm3(Predicted)

L?slichkeit: DMSO: soluble; Ethanol: soluble

pka: 9.98±0.40(Predicted)

Aggregatzustand: Pale yellow oil.

InChI: InChI=1S/C25H38O3/c1-18(11-7-13-21-17-23(26)28-24(21)27)9-6-10-19(2)14-15-22-20(3)12-8-16-25(22,4)5/h10-11,17,24,27H,6-9,12-16H2,1-5H3/b18-11+,19-10+

InChIKey: JPWPYTMXSXYUPG-QZPYEDBESA-N

SMILES: O1C(O)C(CC/C=C(\C)/CC/C=C(\C)/CCC2C(C)(C)CCCC=2C)=CC1=O

Sicherheit

LUFFARIELLOLIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Luffariellolide is a natural sesterterpenoid which reversibly inhibits secretory phospholipase A2 isoforms from bee venom (IC50 = 230 nM) and snake venom, reducing inflammation. It blocks the production of platelet-activating factor in stimulated neutrophils (IC50 = 5 μM). Luffariellolide is also a structural mimic of all-trans retinoic acid (RA) and, at 1 μM, acts as an agonist for the RA receptors RAR α, β, and γ but not for other nuclear receptors. In RA-sensitive cancer cell lines, luffariellolide induces the expression of RAR target genes and inhibits cell growth. It also inhibits the activation of hypoxia-inducible factor by hypoxia (IC50 = 3.6 μM).[Cayman Chemical]

LUFFARIELLOLIDE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

LUFFARIELLOLIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 48)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Aladdin Scientific		tp@aladdinsci.com	United States	52923	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9804	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58
Energy Chemical	021-58432009 400-005-6266	marketing1@energy-chemical.com	China	44896	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8140	58
Wuhan Topule	+86-02787215551 19945035818	2936752263@qq.com	China	7984	58
QUALITY CONTROL SOLUTIONS LTD.	+86-0755-66853366 +8613670046396	export03@qcsrm.com	China	24342	58
amyjet	4006800868;027-59626688 18371453821;18771149750	sales@amyjet.com	China	2917	58

111149-87-2()Verwandte Suche:

Cytidin-5'-(trihydrogen-diphosphat), Mono[2-(trimethylammonio)ethyl]ester, Hydroxid, inneres Salz, Mononatriumsalz Farnesal 3,7-Dimethylocta-2,6-diensure (2E,6E)-Nona-2,6-dien-1-al 3,7-Dimethylnona-2,6-dienal

LUFFARIELLOLIDE
4-[(3E,7E)-4,8-Dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadienyl]-5-hydroxy-2(5H)-furanone
4-[(3E,7E)-4,8-Dimethyl-10-(2,6,6-trimethyl-1-cyclohexenyl)-3,7-decadienyl]-5-hydroxyfuran-2(5H)-one
3-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohexen-1-yl)deca-3,7-dienyl]-2-hydroxy-2H-furan-5-one
2(5H)-Furanone, 4-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadien-1-yl]-5-hydroxy-
Luffariellolide, phospholipase A2 (PLA2) inhibitor. Agonist at RARalpha
111149-87-2

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