MYRIOCIN
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- CAS-Nr.
- 35891-70-4
- Englisch Name:
- MYRIOCIN
- Synonyma:
- ISP-1;ISP-I;C001996;MYRIOCIN;6e))-4s*;NSC 177379;THERMOZYMOCIDIN;Spi-1 inhibitor;Myriocin (ISP-1);Isp-1 suppressant
- CBNumber:
- CB0207522
- Summenformel:
- C21H39NO6
- Molgewicht:
- 401.54
- MOL-Datei:
- 35891-70-4.mol
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MYRIOCIN Eigenschaften
- Schmelzpunkt:
- 170-172℃
- Siedepunkt:
- 636.7±55.0 °C(Predicted)
- Dichte
- 1.123±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- methanol: 2 mg/mL
- Aggregatzustand
- powder
- pka
- 1.79±0.50(Predicted)
- Farbe
- off-white
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.
- InChIKey
- ZZIKIHCNFWXKDY-XFXZXTDPSA-N
- SMILES
- N[C@]([C@@H](O)[C@H](O)C\C=C\CCCCCCC(=O)CCCCCC)(CO)C(=O)O
- CAS Datenbank
- 35891-70-4
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi,Xn |
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| R-S?tze: |
22 |
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| S-S?tze: |
24/25 |
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| RIDADR |
UN 2811 6.1/PG 3 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
JX3890000 |
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| HS Code |
29225090 |
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| Speicherklasse |
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications |
Acute Tox. 3 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
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P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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MYRIOCIN Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
Beschreibung
Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case
Mycelia sterilia. It is a potent immunosuppressant having 10-
to 100-
fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase (K
i = 0.28 nM), the enzyme that catalyzes the first step of sphingolipid biosynthesis. It disrupts substratum adhesion of melanoma cells. It also suppresses cell proliferation in the murine cytotoxic T cell line CTLL-
2 (IC
50 = 15 nM)
via apoptosis. Myriocin suppresses replication of the hepatitis C virus in a murine model.
Chemische Eigenschaften
White powder
Verwenden
Myriocin is a atypical amino acid and an antibiotic with potent immunosuppressant activity. Studies suggest that the immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis
induction. Myriocin very potent inhibitor of serine palmitoyltransferase and thus blocks the synthesis ceramide, a precursor in sphingomyelin and glycosphingolipid biosynthesis. As a result Myriocin i
s a useful biochemical research tool for depleting cells of sphingolipids.
Definition
ChEBI: An amino acid-based antibiotic derived from certain thermophilic fungi; acts as a potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis. Myriocin also possesses immunosuppressant activity.
Allgemeine Beschreibung
A potent immunosuppressant. Displays 10- to 100-fold more potent immunosuppressant activity than cyclosporin A. Potently inhibits serine palmitoyltransferase (SPT; K
i = 280 pM) thereby blocking the synthesis of ceramide. Disrupts substratum adhesion of melanoma cells. Inhibits cell proliferation and induces apoptosis in IL-2 dependent murine cytotoxic T lymphocyte cell line CTLL-2.
MYRIOCIN Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
MYRIOCIN Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 165)Lieferanten
35891-70-4()Verwandte Suche:
- MYRIOCIN
- MYRIOCIN, MYCELIA STERILIA
- THERMOZYMOCIDIN
- 6e))-4s*
- 6-eicosenoicacid,2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-,(2s-(2r*,3s
- [2S,3R,4R,6E]-2-AMINO-3,4-DIHYDROXY-2-[HYDROXYMETHYL]-14-OXO-6-EICOSENOIC ACID
- [2S,3R,4R]-(E)-2-AMINO-3,4-DIHYDROXY-2-[HYDROXYMETHYL]-14-OXO-6-EICOSENOIC ACID
- ISP-I
- MYRIOCIN FROM MYCELIA STERILIA
- 2-Amino-2-hydroxymethyl-3,4-dihydroxy-14- oxoeicos-6-enoic acid
- C001996
- Isp-1 suppressant
- Spi-1 inhibitor
- (2S,3R,4R)-(E)-2-AMino-3,4-dihydroxy-2-hydroxyMethyl-14-oxoeicos-6-enoic Acid
- [2S-(2R*,3S*,4S*,6E)]-2-AMino-3,4-dihydroxy-2-(hydroxyMethyl)-14-oxo-6-eicosenoic Acid
- NSC 177379
- Thermozymocidin, ISP-I, (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid
- ISP-I, Thermozymocidin, (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid
- (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-icosenoic acid
- (2S,3R,4R,E)-2-aMino-3,4-dihydroxy-2-(hydroxyMethyl)-14-oxoicos-6-enoic acid
- TherMozyMocidin, ISP 1
- ISP-I NSC 177379 Myriocin Thermozymocidin
- Myriocin (ISP-1)
- 2S-amino-3R,4R-dihydroxy-2-(hydroxymethyl)-14-oxo-6E-eicosenoic acid
- Myriocin, 99%, from Mycelia sterilia
- Myriocin, Mycelia sterilia - CAS 35891-70-4 - Calbiochem
- 6-Eicosenoic acid, 2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-, (2S,3R,4R,6E)-
- ISP-1
- ISP-I|||Thermozymocidin
- Myriocin (ISP-I), serine palmitoyltransferase inhibitor
- Myriocin, Mycelia sterilia
- Myriocin (Thermozymocidin)
- 35891-70-4
- C21H39NO6
- antibiotic
