Anti-Apg5, Anti-Apg5L, Anti-Apoptosis-specific protein, Anti-ASP, Anti-Atg5 (C-terminal) antibody produced in rabbit, Anti-Autophagy protein 5-like Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Rabbit anti-ATG5 (C-terminal) antibody has been used for western blot analysis in U2OS cells. The antibody has also been used for immunoblot assays in CT26 and MCA205 cells.
Allgemeine Beschreibung
Macroautophagy, usually referred to as autophagy, is a major pathway for bulk degradation of cytoplasmic constituents and organelles. Autophagy is an evolutionary conserved pathway seen in all eukaryotic cells. At least 16 ATG genes, required for autophagosome formation were identified in yeast by genetic screens. For many of these genes, related homologs have been identified in mammals. Atg5, also known as Apg5, is a 32 kDa protein essential for autophagy. Atg5 is covalently modified by Atg12, a ubiquitin-like modifier. This conjugation reaction requires ATP and two enzymes, Atg7 and Atg10, which are E1- and E2-like enzymes, respectively. The Atg12-Atg5 conjugate interacts non-covalently with Atg16. The Atg12-Atg5-Atg16 complex localizes to autophagosome precursors and plays an essential role in autophagosome formation. It has been reported that in addition to the role of Atg5 in the formation of autophagosomes, an Atg5 fragment produced by calpain cleavage has pro-apoptotic properties.
Anti-Apg5, Anti-Apg5L, Anti-Apoptosis-specific protein, Anti-ASP, Anti-Atg5 (C-terminal) antibody produced in rabbit, Anti-Autophagy protein 5-like Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
