NAGLY
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- CAS-Nr.
- 179113-91-8
- Englisch Name:
- NAGLY
- Synonyma:
- N-ARACHIDONOYL GLYCINE;NAGLY;NAGly, CID 5283389;Arachidonyl Glycine;ARACHIDONOYL GLYCINE;N-ARACHIDONYL GLYCINE;N Arachidonylglycine,NArachidonylglycine;N-Arachidonoyl glycine (solution in ethanol);N-(1-OXO-5Z,8Z,11Z,14Z-EICOSATETRAENYL)GLYCINE;2-((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenamido)acetic acid
- CBNumber:
- CB0232490
- Summenformel:
- C22H35NO3
- Molgewicht:
- 361.52
- MOL-Datei:
- 179113-91-8.mol
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NAGLY Eigenschaften
- Siedepunkt:
- 560.9±50.0 °C(Predicted)
- Dichte
- 0.985±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- L?slichkeit
- DMSO: >5 mg/mL, soluble
- Aggregatzustand
- waxy solid
- pka
- 3.58±0.10(Predicted)
- Farbe
- off-white
- Sensitive
- Air Sensitive
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Product is subject to oxidation. Solutions in degassed DMSO may be stored at -20°C for up to 1 month.
- InChIKey
- YLEARPUNMCCKMP-DOFZRALJSA-N
- SMILES
- O=C(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)NCC(O)=O
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| S-S?tze: |
22-24/25 |
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| WGK Germany |
3 |
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| Hazard Classifications |
Carc. 2
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H336 |
Kann Schl?frigkeit und Benommenheit verursachen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Schl?frigkeit und Benommenheit) |
Warnung |
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P261, P271, P304+P340, P312,P403+P233, P405, P501 |
| H351 |
Kann vermutlich Krebs verursachen. |
Karzinogenit?t |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P308+P313 |
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
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NAGLY Chemische Eigenschaften,Einsatz,Produktion Methoden
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Arachidonoyl glycine (N-
arachidonyl glycine; NAGly) has been isolated from cell cultures treated with arachidonoyl ethanolamide (AEA; anandamide), from extracts of mammalian brain, and has also been synthesized as an analog of AEA for structure/activity testing. NAGly may be produced endogenously
via oxidation of AEA, or by transacylation of arachidonoyl CoA. NAGly is reported to have analgesic activities in whole animal experiments. Since it seems to be a very poor ligand for the CB
1 receptor, these effects are probably mediated
via other signaling pathways.
Verwenden
Arachidonoyl glycine (N-arachidonyl glycine; NAGly) has been isolated from cell cultures treated with arachidonoyl ethanolamide (AEA; anandamide), from extracts of mammalian brain, and has also been synthesized as an analog of AEA for structure/activity testing. NAGly may be produced endogenously via oxidation of AEA, or by transacylation of arachidonoyl CoA. NAGly is reported to have analgesic activities in whole animal experiments. Since it seems to be a very poor ligand for the CB1 receptor, these effects are probably mediated via other signaling pathways.[Cayman Chemical]
Biologische Aktivit?t
Endogenous anandamide-like compound. Lacks affinity for CB 1 receptors (K i > 10 μ M), VR1 receptors (EC 50 > 10 μ M) and anandamide transporters (IC 50 > 50 μ M) but causes hot-plate analgesia in mice when given orally, and suppresses tonic inflammatory pain. Also endogenous GlyT2 inhibitor.
NAGLY Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
NAGLY Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 64)Lieferanten
179113-91-8()Verwandte Suche:
- N-ARACHIDONYL GLYCINE
- NAGLY
- N-(1-OXO-5Z,8Z,11Z,14Z-EICOSATETRAENYL)GLYCINE
- ARACHIDONOYL GLYCINE
- N-Arachidonoyl glycine (solution in ethanol)
- Glycine, N-[(5Z,8Z,11Z,14Z)-1-oxo-5,8,11,14-eicosatetraen-1-yl]-
- Arachidonyl Glycine
- NAGly, CID 5283389
- N Arachidonylglycine,NArachidonylglycine
- 2-((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenamido)acetic acid
- N-ARACHIDONOYL GLYCINE
- 179113-91-8
- Cannabinoid receptor
