221635-42-3
中文名稱
2,5-二(1-氮丙啶基)-3-(羥甲基)-6-甲基-2,5-環(huán)己二烯-1,4-二酮
英文名稱
NSC 697726
CAS
221635-42-3
分子式
C12H14N2O3
分子量
234.25
MOL 文件
221635-42-3.mol
221635-42-3 結構式
基本信息
中文別名
2,5-二(1-氮丙啶基)-3-(羥甲基)-6-甲基-2,5-環(huán)己二烯-1,4-二酮 英文別名
RH1NSC 697726
2,5-Di(1-aziridinyl)-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone
2,5-Bis(1-aziridinyl)-3-(hydroxymethyl)-6-methyl-2,5-cyclohexadiene-1,4-dione
2,5-bis(aziridin-1-yl)-3-(hydroxymethyl)-6-methylcyclohexa-2,5-diene-1,4-dione
2,5-Cyclohexadiene-1,4-dione, 2,5-bis(1-aziridinyl)-3-(hydroxymethyl)-6-methyl-
常見問題列表
生物活性
RH1 (NSC 697726) 是一種有效的生物還原劑，在體外和體內具有顯著的抗癌活性。體外研究
Treatment of NQ16 cells with RH1 (50 and 100 nM) for 60 and 120 min results in a significant increase (p< 0.05) in cross-linked DNA. RH1 induces apoptosis in a time- and concentration-dependent manner in NQ16 cells .
體內研究
RH1 exhibits antitumor activity in a dose-dependent manner against NQ16 tumors growing in athymic mice. RH1 treatment (0.4 mg/kg and 0.2 mg/kg) of mice bearing NQ16 tumors results in a significant reduction in tumor volume between treated groups and controls as early as 5 days after the treatment period ended. Low-dose RH1 (0.1 mg/kg) also results in a significant reduction in tumor volume between treated mice and controls.