WS 12
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- CAS-Nr.
- 68489-09-8
- Englisch Name:
- WS 12
- Synonyma:
- AR-15512;AVX-012;(1R,2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexane-1-carboxamide;WS 12;Cooler-12;Acoltremon, 97%;Acoltremon, 97%;WS-12(Acoltremon);Cooling agent WS12;Cooler than menthol
- CBNumber:
- CB02455758
- Summenformel:
- C18H27NO2
- Molgewicht:
- 289.41
- MOL-Datei:
- 68489-09-8.mol
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WS 12 Eigenschaften
- Siedepunkt:
- 447.8±28.0 °C(Predicted)
- Dichte
- 1.029±0.06 g/cm3(Predicted)
- Dampfdruck
- 0-0Pa at 20-50℃
- FEMA
- 4681 | (1R,2S,5R)-N-(4-METHOXYPHENYL)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANECARBOXAMIDE
- storage temp.
- -20°C
- L?slichkeit
- DMSO: >20mg/mL
- Aggregatzustand
- White to off-white powder.
- pka
- 14.18±0.70(Predicted)
- Farbe
- white to off-white
- Geruch (Odor)
- at 100.00 %. cool minty
- Geruchsart
- minty
- JECFA Number
- 2079
- InChI
- 1S/C18H27NO2/c1-12(2)16-10-5-13(3)11-17(16)18(20)19-14-6-8-15(21-4)9-7-14/h6-9,12-13,16-17H,5,10-11H2,1-4H3,(H,19,20)/t13-,16,17/m1/s1
- InChIKey
- HNSGVPAAXJJOPQ-XOKHGSTOSA-N
- SMILES
- COc1ccc(NC(=O)C2C[C@H](C)CC[C@H]2C(C)C)cc1
- LogP
- 3.95 at 22℃ and pH7.7
- CAS Datenbank
- 68489-09-8
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
N |
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| R-S?tze: |
50 |
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| S-S?tze: |
53-61 |
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| RIDADR |
UN 3077 9 / PGIII |
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| WGK Germany |
WGK 3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Aquatic Acute 1
Aquatic Chronic 1 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H410 |
Sehr giftig für Wasserorganismen mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 1 |
Warnung |
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P273, P391, P501 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P391 |
Verschüttete Mengen aufnehmen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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WS 12 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
WS-12 is an agonist of transient receptor potential melastatin 8 (TRPM8). It induces currents in Xenopus oocytes expressing mouse TRPM8 (EC50 = 12 μM) and is selective for TRPM8 over transient receptor potential vanilloid 1-4 (TRPV1-4) and transient receptor potential ankyrin 1 (TRPA1) at 1 mM. WS-12 (6 nmol, i.c.v.) reduces nocifensive behavior induced by capsaicin in wild-type, but not Trpm8-/-, mice. It induces analgesia in the hot plate test, an effect that can be reversed by the opioid receptor antagonist naloxone, in mice.
Chemische Eigenschaften
WS 12 is a odorless white crystalline solid,mp 178 °C, displaying
a strong initial cooling effect and a long-lastingness. It is used particularly is oral
care flavors.
Verwenden
WS 12 is a potent TRPM8 agonist.
Handelsname
Winsense WS-12 (Renessenz)
Biologische Aktivit?t
Potent TRPM8 agonist that acts as a cooling agent (EC 50 = 193 nM).
WS 12 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
WS 12 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 177)Lieferanten
68489-09-8()Verwandte Suche:
- WS 12
- (1R*,2S*)-N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide
- CyclohexanecarboxaMide, N-(4-Methoxyphenyl)-5-Methyl-2-(1-Methylethyl)-, (1R,2S,5R)-
- (2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboximide
- (1R,2S,5R)-N-(4-METHOXYPHENYL)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANECARBOXAMIDE
- Cooling agent WS12
- Cyclohexanecarboxamide, N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)-
- N- (4- methoxy phenyl) - menthol -3- carboxylase
- N-(4-Methoxyphenyl)-p-menthane-3-carboxamide
- N-(4-Methoxyphenyl)-p-menthane-3-carboxamide(WS-12)
- Cooler than menthol
- Cooler-12
- HEK293T,AVX 012,chronic neuropathic pain,TRP Channel,AR 15512,inhibit,AVX012,WS 12,WS12,WS-12,AR15512,AVX-012,Inhibitor,AR-15512,Transient receptor potential channels,analgesic effect,cultured mouse DRG neurons
- (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide
- WS 12, TRPM8 agonist
- (1R,2S,5R)-2-isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboxamide
- WS-12, 10 mM in DMSO
- Acoltremon, 97%
- Acoltremon, 97%
- (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(1-methyl)cyclohexylamide
- (1R,2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexane-1-carboxamide
- AR-15512
- AVX-012
- WS-12(Acoltremon)
- 68489-09-8
