9,10-Deepithio-9,10-didehydro-acanthifolicin
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- CAS-Nr.
- 78111-17-8
- Bezeichnung:
- 9,10-Deepithio-9,10-didehydro-acanthifolicin
- Englisch Name:
- OKADAIC ACID
- Synonyma:
- OA;CS-759;NSC 677083;Okadic acid;Ocadaic Acid;OKADAIC ACID;HALOCHONDRINE A;Okadaic acid,97%;35-Demethyl-DTX 1;OKADAIC ACID, 98+%
- CBNumber:
- CB0246204
- Summenformel:
- C44H68O13
- Molgewicht:
- 805
- MOL-Datei:
- 78111-17-8.mol
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9,10-Deepithio-9,10-didehydro-acanthifolicin Eigenschaften
- Schmelzpunkt:
- 164-166 °C
- alpha
- D20 +21° (c = 0.33 in CHCl3); D25 +25.4° (c = 0.24 in CHCl3)
- Siedepunkt:
- 672.95°C (rough estimate)
- Dichte
- 1.0795 (rough estimate)
- Brechungsindex
- 1.5940 (estimate)
- storage temp.
- -20°C
- L?slichkeit
- DMSO: ≥1 mg/mL
- Aggregatzustand
- translucent film
- pka
- 3.87±0.16(Predicted)
- Farbe
- translucent
- Optische Rotation
- +2120 (CHCl3)
- Wasserl?slichkeit
- It is soluble in ethanol (25 mg/ml), DMSO (25 mg/ml), methanol (<1 mg/ml), chloroform, acetone, ethyl acetate, DMF, and dimethylsulfoxide. Insoluble in water, unless first dissolved in organic solvents, such as DMSO or ethanol.
- Merck
- 13,6891
- Stabilit?t:
- Stable. Light and heat-sensitive. Combustible. Incompatible with strong oxidizing agents.
- InChIKey
- QNDVLZJODHBUFM-WFXQOWMNSA-N
- CAS Datenbank
- 78111-17-8
- EPA chemische Informationen
- 1,7-Dioxaspiro[5.5]undec-10-ene-2-propanoic acid, .alpha,5-dihydroxy-.alpha.,10-dimethyl-8-[(1R,2E)-1-methyl-3-[(2R,4'aR,5R,6'S,8'R,8'aS)-octahydro-8'-hydroxy-6'-[(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl]butyl]-7'-methylenespiro[furan-2(3H),2'(3'H)-pyrano[3,2-b]pyran]-5-yl]-2-propen-1-yl]-, (.alpha.R,2S,5R,6R,8S)- (78111-17-8)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
T |
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| R-S?tze: |
23/24/25-38 |
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| S-S?tze: |
26-36/37-45 |
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| RIDADR |
UN 3462 6.1/PG 1 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
AA8227800 |
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| F |
10 |
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| HazardClass |
6.1(a) |
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| PackingGroup |
II |
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| HS Code |
29321900 |
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| Speicherklasse |
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications |
Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Skin Irrit. 2 |
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| Giftige Stoffe Daten |
78111-17-8(Hazardous Substances Data) |
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| Toxizit?t |
LD50 i.p. in mice: 192 mg/kg (Shibata) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
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9,10-Deepithio-9,10-didehydro-acanthifolicin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R38:Reizt die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
Chemische Eigenschaften
white crystals or powder
Verwenden
Okadaic acid is a widely distributed marine toxin produced by several phytoplanktonic species and responsible for diarrheic shellfish poisoning in humans. At the molecular level, Okadaic acid is a pot
ent and specific inhibitor of various types of serine/threonine protein phosphatases. Due to this enzymatic inhibition, Okadaic acid was reported to induce numerous alterations in relevant cellular ph
ysiological processes, including metabolic pathways such as glucose uptake, lipolysis and glycolysis, heme metabolism and glycogen and protein synthesis.
Allgemeine Beschreibung
Okadaic acid is a polyether fatty acid. It is a marine toxin produced by the genera of
Prorocentrumand
Dinophysis.
Biologische Aktivit?t
Potent inhibitor of protein phosphatase 1 (IC 50 = 3 nM) and protein phosphatase 2A (IC 50 = 0.2-1 nM). Displays > 100,000,000-fold selectivity over PP2B and PP2C. Tumor promotor. Shown to activate atypical protein kinase C in adipocytes.
Sicherheitsprofil
A poison by intraperitoneal route.Questionable carcinogen. Mutation data reported. Whenheated to decomposition it emits acrid smoke andirritating vapors
9,10-Deepithio-9,10-didehydro-acanthifolicin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
1,7-Dioxaspiro[5.5]undec-10-ene-2-propanoic acid, α-hydroxy-α,10-dimethyl-8-[1-methyl-3-[octahydro-6′-[3-(3-methyl-1,7-dioxaspiro[5.5]undec-2-yl)-1-(phenylmethoxy)butyl]-7-methylene-8-(phenylmethoxy)spiro[furan-2(3H),2′(3′H)-pyrano[3,2-b]pyran]-5-yl]-2-propenyl]-5-(phenylmethoxy)-, [2′R-[2′α[R*[1R*[2S*(R*),5R*,6R*,11S*],3E]],4′aβ,6′β[1S*,3S*(2R*,3R*,6S*)],8′α,8′aα]]-
Downstream Produkte
9,10-Deepithio-9,10-didehydro-acanthifolicin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 199)Lieferanten
78111-17-8(9,10-Deepithio-9,10-didehydro-acanthifolicin)Verwandte Suche:
- 1,7-Dioxaspiro[5.5]undec-10-ene-2-propanoicacid, a,5-dihydroxy-a,10-dimethyl-8-[(1R,2E)-1-methyl-3-[(2R,4'aR,5R,6'S,8'R,8'aS)-octahydro-8'-hydroxy-6'-[(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl]butyl]-7'-methylenespiro[furan-2(
- Okadaic acid 35-Demethyl-DTX 1 NSC 677083 35-Demethyldinophysistoxin 1
- OKADAIC ACID, PROROCENTRUM CONCAVUM
- 35-Demethyldinophysistoxin 1
- 35-Demethyl-DTX 1
- NSC 677083
- 9,10-DEEPITHIO-9,10-DIDEHYDROACANTHIFOLICIN
- 9,10-DEEPITHIO-9,10-DIDEHYDROACANTHIOFOLICIN
- HALOCHONDRINE A
- OKADAIC ACID >95% PROTEIN PHOSPHATASE I
- OKADAIC ACID AMMONIUM SALT WATER-SOLUBLE ANALOG
- OKADAIC ACID FREE ACID
- OKADAIC ACID, 25 UG*
- OKADAIC ACID FROM PROROCENTRUM SP.
- OKADAIC ACID SODIUM SALT 98+%
- 9,10-deepithio-9,10-didehydro-acanthifolici
- OKADAIC ACID, 98+%
- Okadaicacid,Prorocentrumconcavum,highpurity
- 1,7-Dioxaspiro5.5undec-10-ene-2-propanoic acid, .alpha.,5-dihydroxy-.alpha.,10-dimethyl-8-(1R,2E)-1-methyl-3-(2R,4aR,5R,6S,8R,8aS)-octahydro-8-hydroxy-6-(1S,3S)-1-hydroxy-3-(2S,3R,6S)-3-methyl-1,7-dioxaspiro5.5undec-2-ylbutyl-7-methylenespirofuran-2(3H),2
- OKADAICACID,HIGHPURITY
- 9,45-Seco-10-demercapto-9,10-didehydroacanthifolicin
- Ocadaic Acid
- Okadic acid
- Okadaic acid,97%
- Blue mussel, homogenized (Okadaic acid)
- Okadaic acid from Prorocentrum concavum,OA
- Okadaic acid, free acid >98%
- OKADAIC ACID
- CS-759
- (2R)-3-[(2S,6R,8S,11R)-2-[(E)-4-[(2R,4R,4aS,6R,8aR)-4-hydroxy-2-[(1S,3S)-1-hydroxy-3-[(2R,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl]-3-methylidenespiro[4a,7,8,8a-tetrahydro-4H-pyrano[3,2-b]pyran-6,5''-oxolane]-2''-yl]but-3-en-2-yl]-11-hydroxy-4-
- 1,7-Dioxaspiro[5.5]undec-10-ene-2-propanoicacid, a,5-dihydroxy-a,10-dimethyl-8-[(1R,2E)-1-methyl-3-[(2R,4'aR,5R,6'S,8'R,8'aS)-octahydro-8'-hydroxy-6'-[(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl]butyl]-7'-methylenespiro[furan-2(3H),2'(3'H)-pyrano[3,2-b]pyran]-5-yl]-2-propen-1-yl]-,(aR,2S,5R,6R,8S)-
- Okadaic acid in methanol
- Carbovir Impurity 2
- Okadaic acid from Prorocentrum concavum
- Okadaic acid solution
- Okadaic acid from Prorocentrum concavum[O9381]
- OA
- 78111-17-8
- C44H68O13
- BioChemical
- Biochemicals and Reagents
- Cell Signaling and Neuroscience
- Cell Biology
- P to Q
- Protein phosphatase-1, Catalytic Subunit
- Protein Phosphatase 1 (PP1)
- Kinase/Phosphatase Biology
- Substrate Analogs
- Serine/Threonine Phosphatase Inhibitors
- Enzymes, Inhibitors, and Substrates
- Enzyme Inhibitors by Enzyme
- Enzyme Inhibitors by Type
- Enzyme Inhibitors
- Natural Products
- Inhibitor
- Signalling
- Protein Phosphatase
