2-[2-(2-Azidoethoxy)ethoxy]ethanamine
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- CAS-Nr.
- 166388-57-4
- Englisch Name:
- 2-[2-(2-Azidoethoxy)ethoxy]ethanamine
- Synonyma:
- N3-PEG2-NH2;N3-PEG2-CH2CH2NH2;Azido-PEG2-Amine;Azido-PEG2-NH2;H2N-C2-PEG2-N3;Azide-PEG3-Amine;Azido-PEG2-C2-amine;Azido-PEG2-CH2CH2NH2;Azido-PEG2-CH2CH2-Amine;Amino-PEG2-azide,NH2-PEG2-N3
- CBNumber:
- CB02484811
- Summenformel:
- C6H14N4O2
- Molgewicht:
- 174.2
- MOL-Datei:
- 166388-57-4.mol
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2-[2-(2-Azidoethoxy)ethoxy]ethanamine Eigenschaften
- storage temp.
- -20°C, protect from light
- L?slichkeit
- Soluble in Water, DMSO, DMF, DCM
- Aggregatzustand
- Liquid
- Farbe
- Colorless to light yellow
- Aussehen
- colorlessoryellowish oil
- InChI
- InChI=1S/C6H14N4O2/c7-1-3-11-5-6-12-4-2-9-10-8/h1-7H2
- InChIKey
- ZHWGWSYNZIZTFL-UHFFFAOYSA-N
- SMILES
- NCCOCCOCCN=[N+]=[N-]
- CAS Datenbank
- 166388-57-4
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H314 |
Verursacht schwere Ver?tzungen der Haut und schwere Augensch?den. |
?tzwirkung auf die Haut |
Kategorie 1B |
Achtung |
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P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501 |
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| Sicherheit |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
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2-[2-(2-Azidoethoxy)ethoxy]ethanamine Chemische Eigenschaften,Einsatz,Produktion Methoden
Synthese
2-[2-(2-Hydroxyethoxy)ethoxy]ethyl chloride (15 g, 88.9 mmol), NaI(4.06 g, 27.1 mmol), and NaN
3 (45.3 mg, 697 mmol) were dissolved in distilled water (90 mL), and the solution was stirred for 48 h at 50 °C. The reaction mixture extracted with ethyl acetate for three times. The organic layer was dried over Na
2SO
4 , and evaporated to collect 2-[2-(2-azidoethoxy)ethoxy]ethanol (14.0 g, 90.1%) as a yellow oil.To the solution 2-[2-(2-azidoethoxy)ethoxy]ethanol (8 g, 45.7 mmol) in THF (22.4 mL), 6 M NaOH(20.8 mL) and TsCl (13.1 g, 68.6 mmol) were added at 0 °C. The reaction mixture was stirred for 1 h at room temperature under nitrogen atmosphere. The solution was then extracted with diethyl ether four times, and the organic layer was washed with 1 M NaOH. After evaporation of the organic layer,2-[2-(2-azidoethoxy)ethoxy]ethyl tosylate (16.8 g, 98.6%) was obtained as a yellow oil.Finally, ammonia solution (28%, 14.8 mL, 365 mol) was added to the 2-[2-(2-azidoethoxy)ethoxy]-ethyl tosylate (8 g, 24.3 mmol) dissolved in THF (95.9 mL), and reaction mixture was stirred for 96 h at 40 °C. After the reaction, distilled water (50 mL) was added to the solution. The mixture was washed with diethyl ether and then extracted with dichloromethane. The organic layer was dried over NaSO
4 and evaporated to obtain 2-[2-(2-azidoethoxy)ethoxy]ethanamine (2.49 g, 58.8%) as a yellow oil.
![synthesis of 2-[2-(2-Azidoethoxy)ethoxy]ethanamine](/NewsImg/2022-10-12/6380118429396640864122844.jpg "synthesis of 2-[2-(2-Azidoethoxy)ethoxy]ethanamine")
2-[2-(2-Azidoethoxy)ethoxy]ethanamine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-[2-(2-Azidoethoxy)ethoxy]ethanamine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 136)Lieferanten
166388-57-4()Verwandte Suche:
3,6,9,12-Tetraoxatetradecan-1,14-diol
3,6,9,12,15,18,21,24,27-Nonaoxanonacosan-1,29-diol
3,6,9,12,15,18-Hexaoxaicosan-1,20-diol
- 2-[2-(2-Azidoethoxy)ethoxy]ethanamine
- Azido-PEG2-NH2
- 2-[2-(2-Azido-ethoxy)-ethoxy]-ethylamine
- Azido-PEG2-C2-amine
- Amino-PEG2-azide,NH2-PEG2-N3
- Azide-PEG3-Amine
- Ethanamine, 2-[2-(2-azidoethoxy)ethoxy]-
- N3-PEG2-CH2CH2NH2/Ethanamine, 2-[2-(2-azidoethoxy)ethoxy]-
- H2N-C2-PEG2-N3
- Azido-PEG2-CH2CH2NH2
- Azido-PEG2-CH2CH2-Amine
- Azido-PEG2-Amine
- N3-PEG2-CH2CH2NH2
- N3-PEG2-NH2
- 166388-57-4
- 1660388-57-4
- peg
