AT9283

896466-04-9

CAS-Nr.: 896466-04-9

Englisch Name:: AT9283

Synonyma:: CS-48;J-504568;AT9283, >=98%;AT-9283; AT 9283;AT9283, 10 mM in DMSO;AT9283 AKSci SYN1011 AT-9283;N-cyclopropyl-N'-[3-[5-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]Urea;1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea;Urea, N-cyclopropyl-N'-[3-[6-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]-;1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea AT9283

CBNumber:: CB02484987

Summenformel:: C19H23N7O2

Molgewicht:: 381.43

MOL-Datei:: 896466-04-9.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 142

AT9283 Eigenschaften

Dichte: 1.45

storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C

L?slichkeit: insoluble in H2O; ≥19.05 mg/mL in DMSO; ≥47.6 mg/mL in EtOH with ultrasonic

Aggregatzustand: solid

pka: 10.58±0.10(Predicted)

Farbe: White to off-white

InChIKey: LOLPPWBBNUVNQZ-UHFFFAOYSA-N

SMILES: [nH]1nc(c(c1)NC(=O)NC5CC5)c2[nH]c3c(n2)ccc(c3)CN4CCOCC4

Sicherheit

WGK Germany	WGK 3
Speicherklasse	11 - Combustible Solids

AT9283 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

AT-9283 is a broad spectrum kinase inhibitor that potently inhibits Aurora A, Aurora B, JAK2, JAK3, and c-ABL (IC50s = 3, 3, 1.2, 1.1, and 4 nM, respectively). It also potently (IC50 = <1 μM) inhibits many other kinases, including serine/threonine kinases as well as receptor and non-receptor tyrosine kinases. As Aurora kinases have roles in mitosis, inhibitors of these kinases, including AT-9283, have potential in cancer therapy. Consistent with this, AT-9283 is effective in preventing proliferation of cancer cells both in vitro and in vivo and this effect may be enhanced by combination therapy with other chemotherapeutics.[Cayman Chemical]

AT9283 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

5H-Pyrazolo[4',3':4,5]pyrimido[1,6-a]benzimidazol-5-one, 2,4-dihydro-8-(4-morpholinylmethyl)- 5H-Pyrazolo[4',3':4,5]pyrimido[1,6-a]benzimidazol-5-one, 2,4-dihydro-9-(4-morpholinylmethyl)- Cyclopropylamin

Downstream Produkte

AT9283 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 142)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32467	58
Shenzhen Shengda Pharma Limited	755-85269922 +8613424394241	sales@shengdapharm.com	CHINA	310	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19853	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9911	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471;	sales@sarms4muscle.com	China	10473	58
Alfa Chemistry	+1-5166625404;	Info@alfa-chemistry.com	United States	20405	58

1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea AT9283
AT9283, >=98%
N-cyclopropyl-N'-[3-[5-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]Urea
Urea, N-cyclopropyl-N'-[3-[6-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]-
1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea
CS-48
AT-9283; AT 9283
J-504568
AT9283 AKSci SYN1011 AT-9283
AT9283, 10 mM in DMSO
896466-04-9
Inhibitor
Inhibitors

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