N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
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- CAS-Nr.
- 315703-52-7
- Englisch Name:
- N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
- Synonyma:
- JK 184;CS-2369;JK184 (JK-184;JK184, 10 mM in DMSO;Hh Signaling Antagonist VII;Hh Signaling Antagonist VII, JK184;JK 184, Hedgehog signaling inhibitor;JK 184;JK-184;HH SIGNALING ANTAGONIST VII;JK-184,inhibit,JK 184,JK184,Inhibitor,Hedgehog;Hh Signaling Antagonist VII, JK184 - CAS 315703-52-7 - Calbiochem
- CBNumber:
- CB02485085
- Summenformel:
- C19H18N4OS
- Molgewicht:
- 350.44
- MOL-Datei:
- 315703-52-7.mol
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N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Eigenschaften
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- L?slichkeit
- DMSO: ≥20mg/mL
- Aggregatzustand
- powder
- Farbe
- off-white to light brown
- InChI
- 1S/C19H18N4OS/c1-3-24-15-9-7-14(8-10-15)21-19-22-16(12-25-19)18-13(2)20-17-6-4-5-11-23(17)18/h4-12H,3H2,1-2H3,(H,21,22)
- InChIKey
- ROYXIPOUVGDTAO-UHFFFAOYSA-N
N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
JK 184 is an imidazopyridine derivative that inhibits downstream hedgehog signaling, preventing Gli-dependent transcriptional activity (IC50 = 30 nM). It does so by inhibiting alcohol dehydrogenase 7 (IC50 = 210 nM) and depolymerizing microtubules, preventing their assembly, which is crucial for Gli function. JK 184 exhibits antiproliferative activity in a range of cancer cell lines (L3.6pl, Panc 05.04, BxPC3, D283 med, Daoy; GI50s = 3-21 nM) and in L3.6pl and BxPC3 pancreatic cancer xenograft models (0.2 mg/mouse/day).[Cayman Chemical]
Biologische Aktivit?t
Potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC 50 = 30 nM). Exhibits antiproliferative activity in a range of cancer cell lines (GI 50 = 3 - 21 nM) and in human xenografts in vivo . Inhibits alcohol dehydrogenase 7 (Adh7) (IC 50 = 210 nM) and acts as a microtubule depolymerizing agent in vitro .
N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 114)Lieferanten
315703-52-7()Verwandte Suche:
- N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
- Hh Signaling Antagonist VII, JK184
- JK 184
- N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine
- 2-ThiazolaMine, N-(4-ethoxyphenyl)-4-(2-MethyliMidazo[1,2-a]pyridin-3-yl)-
- Hh Signaling Antagonist VII, JK184 - CAS 315703-52-7 - Calbiochem
- CS-2369
- JK184 (JK-184
- Hh Signaling Antagonist VII
- JK 184;JK-184;HH SIGNALING ANTAGONIST VII
- JK-184,inhibit,JK 184,JK184,Inhibitor,Hedgehog
- JK 184, Hedgehog signaling inhibitor
- JK184, 10 mM in DMSO
- N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-1,3-thiazol-2-amine
- 315703-52-7
