MC1568
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- CAS-Nr.
- 852475-26-4
- Englisch Name:
- MC1568
- Synonyma:
- MC1568;CS-349;CS-2095;MC1568 ，S1484;MC 1568, >=98%;MC 1568;MC-1568;MC1568 USP/EP/BP;MC1568, 10 mM in DMSO;MC1568;MC 1568;MC-1568;3-[4-[3-(3-Fluorophenyl)-3-oxo-1-propenyl]-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide
- CBNumber:
- CB02517946
- Summenformel:
- C17H15FN2O3
- Molgewicht:
- 314.31
- MOL-Datei:
- 852475-26-4.mol
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MC1568 Eigenschaften
- Schmelzpunkt:
- 212-215 °C(Solv: acetonitrile (75-05-8); methanol (67-56-1))
- Dichte
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: ≥10mg/mL
- Aggregatzustand
- powder
- pka
- 8.91±0.23(Predicted)
- Farbe
- orange
- InChI
- 1S/C17H15FN2O3/c1-20-14(5-6-15(20)8-10-17(22)19-23)7-9-16(21)12-3-2-4-13(18)11-12/h2-11,23H,1H3,(H,19,22)/b9-7+,10-8+
- InChIKey
- QRDAPCMJAOQZSU-KQQUZDAGSA-N
- SMILES
- Cn1c(\C=C\C(=O)NO)ccc1\C=C\C(=O)c2cccc(F)c2
- CAS Datenbank
- 852475-26-4
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn,Xi |
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| R-S?tze: |
22-36 |
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| S-S?tze: |
26 |
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| WGK Germany |
3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Eye Irrit. 2 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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MC1568 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
While class I HDACs are localized predominantly within the nucleus, class II HDACs shuttle into and out of the nucleus in response to intracellular signaling. Class IIa HDACs, which includes HDAC4, 5, 7, and 9, commonly act as corepressors and play diverse roles in cell biology. MC 1568 is a selective inhibitor of class IIa HDACs, with greater than 170-fold selectivity over class I HDACs, including HDAC1. It has been used in cells (1-10 μM) and in mice to elucidate the roles of class IIa HDACs in cell proliferation and differentiation, apoptosis, myogenesis, adipogenesis, and fibrosis.
Verwenden
A selective class II (IIa) histone deacetylase (HDAC II) inhibitor. It exhibits tissue-selective inhibition between members of class II acetylases in vivo, particularly in skeletal muscle and the heart. It arrests myogenesis through the stabilization of myocyte enhancer factor 2D (MEF2D)-HDAC3/4 complex.
Biochem/physiol Actions
MC1568 is a selective class II (IIa) histone deacetylas (HDAC II) inhibitor.
MC1568 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
MC1568 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 140)Lieferanten
- 3-[4-(3-(3-Fluorophenyl)-3-oxo-1-propen-1-yl)-1-Methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenaMide
- (E)-3-(4-((E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide
- 3-[4-[3-(3-Fluorophenyl)-3-oxo-1-propenyl]-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide MC1568
- MC 1568
3-[4-[3-(3-Fluorophenyl)-3-oxo-1-propenyl]-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide
- (E)-3-(5-((E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide
- 3-[5-(3-(3-Fluorophenyl)-3-oxopropen-1-yl)-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide
- MC 1568, >=98%
- (E)-3-(5-((E)-3-(3-fluorophenyl)-3-oxoprop-1-en-1-yl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide
- (E)-3-(4-((E)-3-(3-Fluorophenyl)-3-oxoprop-1-en-1-yl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacryla
- MC1568
- 3-[4-[3-(3-Fluorophenyl)-3-oxo-1-propenyl]-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide
- (E)-3-[4-[(E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl]-1-methylpyrrol-2-yl]-N-hydroxyprop-2-enamide
- MC 1568;MC-1568
- CS-2095
- CS-349
- MC1568 USP/EP/BP
- MC1568;MC 1568;MC-1568
- 2-Propenamide, 3-[5-[(1E)-3-(3-fluorophenyl)-3-oxo-1-propen-1-yl]-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-, (2E)-
- MC1568, 10 mM in DMSO
- MC1568 ，S1484
- 852475-26-4
- Inhibitor
- Aromatics
- API
- Heterocycles
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Selective inhibitor of class II (IIa) histone deacetylase (HDAC).
