IPA-3
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- CAS-Nr.
- 42521-82-4
- Englisch Name:
- IPA-3
- Synonyma:
- IPA 3;IPA 3;IPA3;IPA-3, 10 mM in DMSO;1'-Dithiodi-2-naphthtol;1,1'-Dithiodi-2-naphthtol;2-Naphthalenol, 1,1'-dithiobis-;1,1′-Disulfanediyldinaphthalen-2-ol;Bis(2-hydroxy-1-naphthyl) disulfide;1,1'-Dithiodi-2-naphthtol USP/EP/BP;1,1'-Disulfanediylbis(naphthalen-2-ol)
- CBNumber:
- CB02518903
- Summenformel:
- C20H14O2S2
- Molgewicht:
- 350.45
- MOL-Datei:
- 42521-82-4.mol
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IPA-3 Eigenschaften
- Schmelzpunkt:
- 172℃
- Siedepunkt:
- 543.7±35.0 °C(Predicted)
- Dichte
- 1.46±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: >20mg/mL
- pka
- 7.52±0.50(Predicted)
- Aggregatzustand
- Yellow solid
- Farbe
- off-white to yellow
- Wasserl?slichkeit
- Soluble in DMSO or ethanol. Insoluble in water.
- Sensitive
- Light Sensitive
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
- InChI
- 1S/C20H14O2S2/c21-17-11-9-13-5-1-3-7-15(13)19(17)23-24-20-16-8-4-2-6-14(16)10-12-18(20)22/h1-12,21-22H
- InChIKey
- RFAXLXKIAKIUDT-UHFFFAOYSA-N
- SMILES
- Oc1ccc2ccccc2c1SSc3c(O)ccc4ccccc34
- CAS Datenbank
- 42521-82-4
IPA-3 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
p21-activated kinase 1 (PAK1) is a member of a family non-receptor serine/threonine kinases that are vital to normal cell function. Binding of various upstream partners to PAK1 results in release of an autoinhibitory domain that blocks activity of the kinase domain. PAK1 expression and activity is upregulated in several human cancers and is a potential therapeutic target for cancer intervention. IPA-3 is a cell-permeable allosteric inhibitor of PAK1 that is non-competitive with respect to ATP binding (IC50 = 2.5 μM). It does not, however, inhibit the activity of PAK1 that has been pre-activated with Cdc42. IPA-3 binds covalently to the PAK1 regulatory domain (apparent Kd = 1.9 uM) and prevents binding to the upstream activator Cdc42.[Cayman Chemical]
Definition
ChEBI: An organic disulfide obtained by oxidative dimerisation of 1-sulfanylnaphthalen-2-ol.
Biochem/physiol Actions
IPA-3 is an allosteric inhibitor of Pak1. It binds to autoinhibitory domain of Pak1 (p21 activated kinase), highly selective amongst kinases. Pak1 is implicated in tumorigenesis and metastasis.
IPA-3 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
IPA-3 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 139)Lieferanten
- 1,1'-Dithiodi-2-naphthtol
- IPA 3
- p21-Activated Kinase Inhibitor III, IPA-3
- Bis(2-hydroxy-1-naphthyl) disulfide
- 2-Naphthalenol, 1,1'-dithiobis-
- 1,1′-Disulfanediyldinaphthalen-2-ol
- 1,1'-Disulfanediylbis(naphthalen-2-ol)
- IPA 3;IPA3
- p21-Activated Kinase Inhibitor III, IPA-3 - CAS 42521-82-4 - Calbiochem
- 1-[(2-hydroxy-1-naphthyl)disulfanyl]naphthalen-2-ol
- 1'-Dithiodi-2-naphthtol
- 1,1'-Dithiodi-2-naphthtol USP/EP/BP
- inhibit,Inhibitor,IPA-3,p21 activated kinases,PAK
- IPA 3, Group I, p21-activated kinase (PAK) inhibitor
- IPA-3, 10 mM in DMSO
- 42521-82-4
- Inhibitors
- PAK Inhibitor III, IPA-3
- PAK Inhibitor III
- 1,1'-disulfanediylbis(naphthalen-2-ol)
