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GW1929

GW1929 Struktur
196808-24-9
CAS-Nr.
196808-24-9
Englisch Name:
GW1929
Synonyma:
L-Tyrosine, N-(2-benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-;GW1929;GW1929 HYDRATE;GW 1929 hydrochlorid;GW 1929 hydrochloride;GW1929, 10 mM in DMSO;GW1929, PPARgamma agonist;GW1929 - CAS 196808-24-9 - Calbiochem;N-(2-BENZOYLPHENYL)-O-[2-(METHYL-2-PYRIDINYLAMINO)ETHYL]-L-TYROSINE;N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine hydrate
CBNumber:
CB0259985
Summenformel:
C30H29N3O4
Molgewicht:
495.57
MOL-Datei:
196808-24-9.mol

GW1929 Eigenschaften

Siedepunkt:
749.2±60.0 °C(Predicted)
Dichte
1.264±0.06 g/cm3(Predicted)
storage temp. 
Desiccate at +4°C
L?slichkeit
DMSO: 20 mg/mL
Aggregatzustand
solid
pka
3.91±0.10(Predicted)
Farbe
yellow
InChIKey
QTQMRBZOBKYXCG-MHZLTWQESA-N
SMILES
C(O)(=O)[C@H](CC1=CC=C(OCCN(C)C2=NC=CC=C2)C=C1)NC1=CC=CC=C1C(=O)C1=CC=CC=C1

Sicherheit

WGK Germany  3
Speicherklasse 11 - Combustible Solids

GW1929 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Peroxisome proliferator-activated receptor (PPAR) γ is a nuclear receptor that, when activated, regulates fatty acid storage and glucose metabolism. The best known class of PPARγ ligands are the thiazolidinediones, including troglitazone and rosiglitazone. GW 1929 is a non-thiazolidinedione activator of PPARγ that binds with a Ki value of 1.4 nM, with greater than 1,000-fold selectivity over other PPAR subtypes. It has anti-hyperglycemic and anti-hyperlipidemic activity when given orally in mouse and rat models of type 2 diabetes. Both in vitro and in vivo effects of GW 1929 on PPARγ greatly exceed those produced by troglitazone. In addition, GW 1929 has neuroprotective effects in global cerebral ischemic-reperfusion injury that are related to reduced inflammation and apoptotic DNA fragmentation.

Verwenden

GW1929 has been used as a peroxisome proliferator-activated receptor γ (PPARγ) ligand:
Investigating its impact on the expression of plant homeodomain finger protein 16 (Phf16) and patatin-like phospholipase domain containing 3 (Pnpla3) in relation to adipogenesis.
Examining its influence on complement component 3 (C3) gene expression in human hepatoma cells.
Activating PPARγ in human breast cancer cells.

Biologische Aktivit?t

Highly selective orally active peroxisome proliferator-activated receptor (PPAR) γ agonist (pEC 50 values are 8.05, < 4 and < 4 for human PPAR γ , PPAR α and PPAR δ receptors respectively). Decreases glucose, fatty acid and triglyceride levels following oral administration in vivo .

Einzelnachweise

[1] heppner tj,bonev ad,eckman dm,gomez mf,petkov gv,nelson mt. novel ppargamma agonists gi 262570, gw 7845, gw 1929, and pioglitazone decrease calcium channel function and myogenic tone in rat mesenteric arteries. pharmacology.2005 jan;73(1):15-22.
[2] kaundal rk,sharma ss. ameliorative effects of gw1929, a nonthiazolidinedione pparγ agonist, on inflammation and apoptosis in focal cerebral ischemic-reperfusion injury. curr neurovasc res.2011 aug 1;8(3):236-45.
[3] GW1929: a nonthiazolidinedione PPARγ agonist, ameliorates neurological damage in global cerebral ischemic-reperfusion injury through reduction in inflammation and DNA fragmentation DOI: 10.1016/j.bbr.2010.09.001

GW1929 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


GW1929 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 142)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Career Henan Chemica Co
+86-0371-86658258 +8613203830695
laboratory@coreychem.com China 30224 58
BOC Sciences
16314854226; +16314854226
inquiry@bocsci.com United States 19853 58
Hefei Hirisun Pharmatech Co., Ltd
+8615056975894
shawn@hirisunpharm.com CHINA 9911 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6391 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207
sales@molcore.com China 49734 58
Aladdin Scientific

tp@aladdinsci.com United States 52923 58
NANJING YINGWEN BIOTECHNOLOGY CO LTD
+8613382787392
sales@aeechem.com China 10002 58
Amadis Chemical Company Limited
571-89925085
sales@amadischem.com China 131956 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 18892239720
psaitong@jm-bio.com China 12306 58
Nanjing Yiming Pharmaceutical Technology Co., Ltd. 19850700912; 19850700912
13851286085@163.com China 583 58

196808-24-9()Verwandte Suche:


  • GW1929
  • GW1929 HYDRATE
  • N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine hydrate
  • (2S)-2-(2-benzoylanilino)-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]propanoic acid
  • (S)-2-(2-Benzoylphenylamino)-3-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)phenyl)propanoic acid
  • GW 1929 hydrochloride
  • N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosinehydrochloride
  • N-(2-BENZOYLPHENYL)-O-[2-(METHYL-2-PYRIDINYLAMINO)ETHYL]-L-TYROSINE
  • GW 1929 hydrochlorid
  • GW1929 - CAS 196808-24-9 - Calbiochem
  • (2S)-2-[(2-benzoylphenyl)amino]-3-(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)propanoic acid
  • GW1929, PPARgamma agonist
  • GW1929, 10 mM in DMSO
  • L-Tyrosine, N-(2-benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-
  • 196808-24-9
  • PPAR and RXR Regulators
  • Gene Regulation and Expression
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Intracellular receptor
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