5-Carboxy-8-hydroxyquinoline
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- CAS-Nr.
- 5852-78-8
- Englisch Name:
- 5-Carboxy-8-hydroxyquinoline
- Synonyma:
- IOX1;8-Hydroxyquinoline-5-carboxylic Acid;CS-1524;IOX-1;IOX 1;IOX 1, >=98%;IOX1, 10 mM in DMSO;5-Carboxy-8-hydroxyquinoline;JMJD2 Inhibitor, 5-carboxy-8HQ;8-hydroxy-5-Quinolinecarboxylic acid;5-Carboxy-8-hydroxyquinoline USP/EP/BP
- CBNumber:
- CB02671446
- Summenformel:
- C10H7NO3
- Molgewicht:
- 189.17
- MOL-Datei:
- 5852-78-8.mol
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5-Carboxy-8-hydroxyquinoline Eigenschaften
- Schmelzpunkt:
- 301 °C (decomp)
- Siedepunkt:
- 464.5±30.0 °C(Predicted)
- Dichte
- 1.480±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: soluble10mg/mL, clear
- pka
- 1.82±0.10(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to brown
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
- InChI
- 1S/C10H7NO3/c12-8-4-3-7(10(13)14)6-2-1-5-11-9(6)8/h1-5,12H,(H,13,14)
- InChIKey
- JGRPKOGHYBAVMW-UHFFFAOYSA-N
- SMILES
- OC(=O)c1ccc(O)c2ncccc12
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22 |
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| WGK Germany |
3 |
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| HS Code |
2933499090 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P271 |
Nur im Freien oder in gut belüfteten R?umen verwenden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
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5-Carboxy-8-hydroxyquinoline Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
5-Carboxy-8-hydroxyquinoline is an inhibitor of KDM2/7 histone demethylase. 5-Carboxy-8-hydroxyquinoline has also shown potential to be used as a regulator of plant growth.
Biochem/physiol Actions
IOX1 (5-Carboxy-8-hydroxyquinoline) is a broad spectrum inhibitor of 2-oxoglutarate (2OG) oxygenases, including Jumonji C domain (JmjC) demethylases. It is useful for the study of histone demethylation and hypoxic sensing and results in translocation of active site iron on the 2OG oxygenases. For full characterization details, please visit the IOX1 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
5-Carboxy-8-hydroxyquinoline Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5-Carboxy-8-hydroxyquinoline Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 165)Lieferanten
5852-78-8()Verwandte Suche:
- 5-Carboxy-8-hydroxyquinoline
- 8-hydroxy-5-Quinolinecarboxylic acid
- IOX 1, >=98%
- JMJD2 Inhibitor, 5-carboxy-8HQ
- 8-Hydroxyquinoline-5-carboxylic acid 95%
- JMJD2 Inhibitor, 5-carboxy-8HQ - CAS 5852-78-8 - Calbiochem
- CS-1524
- IOX-1;IOX 1
- 5-Quinolinecarboxylic acid, 8-hydroxy-
- 5-Carboxy-8-hydroxyquinoline USP/EP/BP
- 8-Hydroxyquinoline-5-carboxylic Acid
- IOX1
- IOX-1, histone demethylase JMJD inhibitor
- IOX1, 10 mM in DMSO
- 5852-78-8
- Inhibitors
- Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
- 123456
