Tranilast
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- CAS-Nr.
- 53902-12-8
- Englisch Name:
- Tranilast
- Synonyma:
- n-5’;MK 341;TraniL;Qunist;rizaben;Tranpro;ranilas;Qunister;SB-252218;TRANILAST
- CBNumber:
- CB0289227
- Summenformel:
- C18H17NO5
- Molgewicht:
- 327.33
- MOL-Datei:
- 53902-12-8.mol
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Tranilast Eigenschaften
- Schmelzpunkt:
- 166.2-168.2 °C (lit.)
- Siedepunkt:
- 465.23°C (rough estimate)
- Dichte
- 1.3185 (rough estimate)
- Brechungsindex
- 1.5100 (estimate)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: 18 mg/mL
- Aggregatzustand
- powder
- pka
- 3.47±0.36(Predicted)
- Farbe
- white to beige
- Merck
- 14,9570
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
- InChI
- 1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+
- InChIKey
- NZHGWWWHIYHZNX-CSKARUKUSA-N
- SMILES
- COc1ccc(\C=C\C(=O)Nc2ccccc2C(O)=O)cc1OC
- CAS Datenbank
- 53902-12-8(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22 |
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| S-S?tze: |
26-36 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
DG8731000 |
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| HS Code |
2924.29.6250 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Acute Tox. 4 Oral |
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| Toxizit?t |
LD50 in male, female mice, male, female rats (mg/kg): 780, 680, 1600, 1100 orally; 410, 385, 405, 395 i.p.; 2630, 2820, 3630, 3060 s.c. (Nakazawa, p 385) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Tranilast Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Pale Green Solid
Verwenden
Tranilast is a compound that exhibits anti-inflammatory and immunomodulatory effects by inhibiting lipid mediator and cytokine release from inflammatory cells and interfering with PDGF- and TGF-β1-induced proliferation and migration of vascular medial smooth muscle cells. Tranilast suppresses production of prostaglandin D2 (IC50 = 0.1 mM), prostaglandin E2 (IC50 = ~1-20 μM), thromboxane B2 (IC50 = ~10-50 μM), TGF-β1 (IC50 = ~100-200 μM), and interleukin-8 (IC50 = ~100 μM) in in vitro models as well as attenuates of the proinflammatory activity of human monocytes. While originally marketed as an antiallergenic drug, the efficacy of tranilast in preventing restenosis after percutaneous coronary intervention has been tested in a large-scale clinical trial. Additionally, tranilast inhibits VEGF-induced angiogenetic activities (i.e., proliferation, migration and tube formation of vascular endothelial cells) with IC50 values of 22, 18 and 193 μM, which may prove therapeutic for various retinal diseases.[Cayman Chemical]
Definition
ChEBI: An amidobenzoic acid that is anthranilic acid in which one of the anilino hydrogens is replaced by a 3,4-dimethoxycinnamoyl group.
Biologische Aktivit?t
Antiallergic via inhibition of chemical mediator release from mast cells. Most recently shown to be an effective inhibitor of angiogenesis. Demonstrated to antagonize the effects of angiotensin II on human arteries, possibly by an interaction at the level of the AT 1 receptor.
Tranilast Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Tranilast Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 327)Lieferanten
53902-12-8()Verwandte Suche:
- 2-((3-(3,4-dimethoxyphenyl)-1-oxo-2-propenyl)amino)-benzoicaci
- n-(3,4-dimethoxycinnamoyl)-anthranilicaci
- n-5’
- rizaben
- SB-252218
- N-(3',4'-DIMETHOXYCINNAMOYL)ANTHRANILIC ACID
- 2-[[3-(3,4-DIMETHOXYPHENYL)-1-OXO-2-PROPENYL]AMINO] BENZOIC ACID
- TRANILAST
- 3,4-DAA, N-(3,4-Dimethoxycinnamoyl)anthranilic acid, Rizaben, SB-252218, 2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino] benzoic acid
- Tranilast(SB 252218)
- 2-[[3-(3,4-DiMethoxyphenyl)-1-oxo-2-propen-1-yl]aMino]benzoic Acid
- Tranpro
- Anthranilic acid, N-(3,4-dimethoxycinnamoyl)-
- Benzoic acid, 2-[[3-(3,4-dimethoxyphenyl)-1-oxo-2-propenyl]amino]-
- MK 341
- Benzoicacid, 2-[[3-(3,4-diMethoxyphenyl)-1-oxo-2-propen-1-yl]aMino]-
- (E)-2-(3-(3,4-dimethoxyphenyl)acrylamido)benzoic acid
- (E)-2-(3-(3,5-dimethoxyphenyl)acrylamido)benzoic acid
- Tranilast - CAS 53902-12-8 - Calbiochem
- 2-[[(E)-3-(3,4-dimethoxyphenyl)-1-oxoprop-2-enyl]amino]benzoate
- Nano Liposomal Tranilast
- Rizaben,MK 341,Tranpro
- TraniL
- Tranilast USP/EP/BP
- 2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid
- Song bannister
- ranilas
- Qunist
- Qunister
- Quinisert
- Tranilast, Anti-inflammatory agent
- Tranilast, 10 mM in DMSO
- Tranilast - Bio-X ?
- 2-[[3-(3,4-dimethyloxyphenyl)-1-oxy-2-propyleneyl]amino]benzenemacetic acid
- Tranilast (Standard)
- 53902-12-8
- C18H17NO5
- Inhibitors
- Angiogenesis and Metastasis
- Amines
- Aromatics
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Angiotensin
- PEXID
