GlyT2-IN-1
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- CAS-Nr.
- 448947-81-7
- Englisch Name:
- GlyT2-IN-1
- Synonyma:
- Yoda 1;CS-2063;GlyT2-IN-1;GlyT2-IN-1(YODA 1);Yoda1 >=98% (HPLC);Yoda 1 (GlyT2-IN-1);Yoda 1, 10 mM in DMSO;2-((2,6-Dichlorobenzyl)thio)-5-(pyrazin-2-yl)-1,3,4-thiadiazole;2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine;Pyrazine, 2-[5-[[(2,6-dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]-
- CBNumber:
- CB03048654
- Summenformel:
- C13H8Cl2N4S2
- Molgewicht:
- 355.27
- MOL-Datei:
- 448947-81-7.mol
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GlyT2-IN-1 Eigenschaften
- Schmelzpunkt:
- 136 - 138°C
- Siedepunkt:
- 538.4±60.0 °C(Predicted)
- Dichte
- 1.58±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO (Slightly), Methanol (Very Slightly)
- pka
- -1.32±0.10(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
- InChI
- 1S/C13H8Cl2N4S2/c14-9-2-1-3-10(15)8(9)7-20-13-19-18-12(21-13)11-6-16-4-5-17-11/h1-6H,7H2
- InChIKey
- BQNXBSYSQXSXPT-UHFFFAOYSA-N
- SMILES
- [s]1c(nnc1c3nccnc3)SCc2c(cccc2Cl)Cl
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| HS Code |
2934999090 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Acute Tox. 4 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
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GlyT2-IN-1 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Yoda 1 is a piezo1 channel activator, sensitizes piezo1 to activation by pressure and slows the inactivation phase of transient currents in human embryonic kidney (HEK) cells.
Allgemeine Beschreibung
Yoda1 is a novel synthetic small molecule developed to study the kinetics, regulation and function of the cation channel Piezo-type mechanosensitive ion channel component 1 (Piezo1).
Biochem/physiol Actions
Yoda1 is a specific activator of mouse and human cation channel Piezo1, a mechanosensitive channel that mediates Ca2+ influx on mechanical activation and has been linked to a role in blood vessel development. Yoda1 stabilizes the Piezo1 open channel. In red blood cells, this was followed by downstream activation of the KCa3.1 Gardos channel with resultant calcium influx and potassium and water efflux, causing shrinkage of the cells. Yoda1 is the first Piezo1 agonist, giving the first evidence of non-mechanical activation of a Piezo channel.
GlyT2-IN-1 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
GlyT2-IN-1 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 126)Lieferanten
- GlyT2-IN-1
- Yoda 1
- GlyT2-IN-1(YODA 1)
- Yoda 1 (GlyT2-IN-1)
- Yoda1 >=98% (HPLC)
- Pyrazine, 2-[5-[[(2,6-dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]-
- 2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine
- CS-2063
- 2-((2,6-Dichlorobenzyl)thio)-5-(pyrazin-2-yl)-1,3,4-thiadiazole
- KcsA,Potassium Channel,Akt,Yoda-1,PKB,Inhibitor,A431 cells,Yoda 1,HCAECs,inhibit,Protein kinase B,ERK,Piezo1,Extracellular signal regulated kinases,Endothelial cells,ERK1/2,Piezo Channel,Yoda1
- Yoda 1, 10 mM in DMSO
- 448947-81-7
- C13H8Cl2N4S2
