SR17018

2134602-45-0

CAS-Nr.: 2134602-45-0

Englisch Name:: SR17018

Synonyma:: CS-2685;SR17018;SR-17018 SR17018;SR17018, 10 mM in DMSO;SR1 7018;SR-17018;SR17018;SR 17018,SR17018,Opioid Receptor,inhibit,SR-17018,Inhibitor;5,6-dichloro-3-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-1H-benzimidazol-2-one;5,6-Dichloro-1-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one;2H-Benzimidazol-2-one, 5,6-dichloro-1-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-1,3-dihydro-;5,6-dichloro-1-{1-[(4-chlorophenyl)methyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one

CBNumber:: CB03382343

Summenformel:: C19H18Cl3N3O

Molgewicht:: 410.72

MOL-Datei:: 2134602-45-0.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 76

SR17018 Eigenschaften

Dichte: 1.428±0.06 g/cm3(Predicted)

storage temp.: Store at -20°C

L?slichkeit: DMSO:6.0(Max Conc. mg/mL);14.61(Max Conc. mM)

Aggregatzustand: A crystalline solid

pka: 10.03±0.30(Predicted)

Farbe: White to off-white

InChI: InChI=1S/C19H18Cl3N3O/c20-13-3-1-12(2-4-13)11-24-7-5-14(6-8-24)25-18-10-16(22)15(21)9-17(18)23-19(25)26/h1-4,9-10,14H,5-8,11H2,(H,23,26)

InChIKey: LAGUDYUGRSQDKS-UHFFFAOYSA-N

SMILES: C1(=O)N(C2CCN(CC3=CC=C(Cl)C=C3)CC2)C2=CC(Cl)=C(Cl)C=C2N1

Sicherheit

SR17018 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

SR17018 is an mu-opioid-receptor (MOR) agonist with an EC50 of 97 nM.

Biologische Aktivit?t

Opioid analgesia is accompanied by side effects including tolerance, respiratory depression, constipation, and opioid induced hyperalgesia (OIH), which primarily mediated via the activation of μ receptors. Research suggest that the detrimental effects might be minimised by restricting β-arrestin2 recruitment to the μ receptor. SR17018 is a high-efficacy activator of G-protein signalling with limited capacity to stimulate β-arrestin2 recruitment largely through a non-competitive agonist action^[1].

SR17018 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

SR17018 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 76)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
.GZ HONESTCHEM CO.,LTD	+8615013270415	honestchemical@foxmail.com	China	248	58
Zhengzhou Anbu Chem Co.,Ltd	+86-0371-88006763; +8615988602810	sales@anbuchem.com	China	3016	58
NANJING YINGWEN BIOTECHNOLOGY CO LTD	+8613382787392	sales@aeechem.com	China	10002	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81139210 +86-18192627656	1059@dideu.com	China	3703	58
Shaanxi Dideu Medichem Co. Ltd	+8617392709771	1097@dideu.com	China	3992	58
Shaanxi Didu New Materials Co. Ltd	+86-86-17392712697 +8617792793228	1069@dideu.com	China	8662	58
ARCTIC EXPORTS INC	+1-3026880818 +1-3026880818;	ARCTICEXPORTSINC@GMAIL.COM	Canada	71	58
Xi an Biohorlden Industry Trade Co Ltd	+86-18829283179 +86-13636819721	sales@horlden.com	China	334	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32467	58

SR17018
CS-2685
SR1 7018;SR-17018;SR17018
2H-Benzimidazol-2-one, 5,6-dichloro-1-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-1,3-dihydro-
SR 17018,SR17018,Opioid Receptor,inhibit,SR-17018,Inhibitor
SR-17018 SR17018
5,6-dichloro-1-{1-[(4-chlorophenyl)methyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
SR17018, 10 mM in DMSO
5,6-dichloro-3-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-1H-benzimidazol-2-one
5,6-Dichloro-1-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one
2134602-45-0
API

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