1-[4-(1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL]ETHANONE
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- CAS-Nr.
- 94944-70-4
- Englisch Name:
- 1-[4-(1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL]ETHANONE
- Synonyma:
- 2-Acetyl-5-tetrahydroxybutyl Imidazole;2-Athbi;2-ATHBI, 10 mM in DMSO;Inhibitor,inhibit,2 ATHBI,2ATHBI;2-acetyl-4(5)-tetrahydroxybutylimidazole;2-Acetyl-5-tetrahydroxybutyl iMidazole (THI);2-Acetyl-4-tetrahydroxybutylimidazole Standard;2-Acetyl-4-(1,2,3,4-tetrahydroxybutyl)iMidazole, 97%;2-Acetyl-4-(1,2,3,4-tetrahydroxybutyl)imidazole, 97%,;(R,S,R)-2-Acetyl-4-(1,2,3,4-tetrahydroxybutyl)-imidazole
- CBNumber:
- CB0371535
- Summenformel:
- C9H14N2O5
- Molgewicht:
- 230.22
- MOL-Datei:
- 94944-70-4.mol
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1-[4-(1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL]ETHANONE Eigenschaften
- Schmelzpunkt:
- approximate 230℃ (dec.)
- Siedepunkt:
- 613.5±65.0 °C(Predicted)
- Dichte
- 1.536±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: soluble2mg/mL, clear (warmed)
- Aggregatzustand
- Powder
- pka
- 10.63±0.10(Predicted)
- Farbe
- white to light brown
- Wasserl?slichkeit
- Soluble in distilled water, DMSO (>5 mg/ml), clear (warmed), and PBS pH 7.2 (~0.15 mg/ml).
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
- InChI
- 1S/C9H14N2O5/c1-4(13)9-10-2-5(11-9)7(15)8(16)6(14)3-12/h2,6-8,12,14-16H,3H2,1H3,(H,10,11)/t6-,7-,8-/m1/s1
- InChIKey
- CQSIXFHVGKMLGQ-BWZBUEFSSA-N
- SMILES
- CC(=O)c1nc(c[nH]1)[C@@H](O)[C@H](O)[C@H](O)CO
- CAS Datenbank
- 94944-70-4
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22 |
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| WGK Germany |
3 |
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| HS Code |
29332900 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P330 |
Mund ausspülen. |
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1-[4-(1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL]ETHANONE Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Sphingosine-1-phosphate (S1P) lyase catalyzes the irreversible decomposition of S1P to hexadecanaldehyde and phosphoethanolamine. 2-Acetyl-5-tetrahydroxybutyl imidazole (THI) is an inhibitor of S1P lyase. Because S1P lyase is primarily expressed in lymphatic tissue, treatment of mice with THI (50 μg/ml in drinking water) increases lymphoid tissue S1P concentrations 100-fold, reducing lymphocyte egress from thymus and peripheral lymphoid organs. The resulting lymphopenia is reversible following cessation of THI treatment. Reducing S1P lyase activity results in therapeutic levels of immunosuppression without the non-lymphoid lesions that result from synthetic S1P receptor agonists.
Biochem/physiol Actions
2-Acetyl-5-tetrahydroxybutyl imidazole (THI) can block S1P lyase in vivo and up-regulates circulatory and tissue S1P levels. It has the ability to repress dystrophic muscle degeneration.
1-[4-(1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL]ETHANONE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
(3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)tetrahydro-2H-pyran-2,4,5-triol hydrochloride
(3S,4S,5R)-2-(aminomethyl)-5-(hydroxymethyl)tetrahydrofuran-2,3,4-triol acetate
1,3-Dithiolane-2-carboxaldehyde, 2-methyl-
2-?Propenimidic acid, 2-?ethoxy-?, methyl ester
1-Amino-1-deoxy-D-fructose Acetate
alpha-Ethoxyacrylonitrile
Glucosaminhydrochlorid
Methanol
Downstream Produkte
1-[4-(1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL]ETHANONE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 76)Lieferanten
- 1-[4-(1,2,3,4-TETRAHYDROXYBUTYL)-1H-IMIDAZOL-2-YL]ETHANONE
- 2-acetyl-4(5)-tetrahydroxybutylimidazole
- 2-ACETYL-4(5)-(1,2,3,4-TETRAHYDROXYBUTYL)-IMIDAZOLE (THI)
- 2-Athbi
- Ethanone, 1-(4-(1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)-, (1R-(1R*,2S*,3R*))-
- Ethanone, 1-[5-[(1R,2S,3R)-1,2,3,4-tetrahydroxybutyl]-1H-iMidazol-2-yl]-
- Ethanone, 1-[4-(1,2,3,4-tetrahydroxybutyl)-1H-iMidazol-2-yl]-, [1R-(1R*,2S*,3R*)]- (9CI)
- 2-Acetyl-4-(1,2,3,4-tetrahydroxybutyl)iMidazole, 97%
- 2-Acetyl-5-tetrahydroxybutyl iMidazole (THI)
- 1-[5-[(1R,2S,3R)-1,2,3,4-Tetrahydroxybutyl]-1H-imidazol-2-yl]ethanone
- (R,S,R)-2-Acetyl-4-(1,2,3,4-tetrahydroxybutyl)-imidazole
- (1'R,2'S,3'R)-2-acetyl-4(5)-(1',2',3',4'-tetrahydroxy-1'-butyl)imidazole
- 2-Acetyl-4-tetrahydroxybutylimidazole Standard
- 1-(5-(1,1,2,2-Tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone
- 2-Acetyl-4-(1,2,3,4-tetrahydroxybutyl)imidazole, 97%,
- Inhibitor,inhibit,2 ATHBI,2ATHBI
- 2-Acetyl-4-(1(R),2(S),3(R),4-tetrahydroxybutyl)imidazole, sphingosine-1-phosphate lyase inhibitor
- 2-ATHBI, 10 mM in DMSO
- 2-Acetyl-5-tetrahydroxybutyl Imidazole
- 94944-70-4
