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1-Butylbiguanidmonohydrochlorid

BuforMin Hydrochloride Struktur
1190-53-0
CAS-Nr.
1190-53-0
Bezeichnung:
1-Butylbiguanidmonohydrochlorid
Englisch Name:
BuforMin Hydrochloride
Synonyma:
BUTYL-BIGUANIDE HYDROCHLORIDE;Andere;Adebit;TideMol;Biforon;Sindiatil;PanforMin;Ziavetine;NSC528218;Aids126511
CBNumber:
CB0407151
Summenformel:
C6H16ClN5
Molgewicht:
193.68
MOL-Datei:
1190-53-0.mol

1-Butylbiguanidmonohydrochlorid Eigenschaften

Schmelzpunkt:
177-179C
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
L?slichkeit
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
Aggregatzustand
Solid
Farbe
White to Off-White
Wasserl?slichkeit
H2O: 25mg/mL, clear
Stabilit?t:
Hygroscopic
InChI
1S/C6H15N5.ClH/c1-2-3-4-10-6(9)11-5(7)8;/h2-4H2,1H3,(H6,7,8,9,10,11);1H
InChIKey
KKLWSPPIRBIEOV-UHFFFAOYSA-N
SMILES
[Cl-].N\C(=N/CCCC)\N=C(N)N.[H+]
CAS Datenbank
1190-53-0
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
R-S?tze: 22-43-36
S-S?tze: 36/39-46
WGK Germany  WGK 3
HS Code  29212900
Speicherklasse 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3
Toxizit?t LD50 i.p. in mice: 380 mg/kg (Rikimaru)
Bildanzeige (GHS) Corrosion (GHS05)Exclamation Mark (GHS07)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H318 Verursacht schwere Augensch?den. Schwere Augensch?digung Kategorie 1 Achtung P280, P305+P351+P338, P310
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P271 Nur im Freien oder in gut belüfteten R?umen verwenden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P332+P313 Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

1-Butylbiguanidmonohydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Buformin is a biguanide derivative with antihyperglycemic activity. It delays absorption of glucose from the gastrointestinal tract, increases insulin sensitivity and glucose utilization in peripheral cells, and inhibits hepatic gluconeogenesis. It can also deactivate the glycolytic pathway by suppressing glyceraldehyde 3-phosphate dehydrogenase gene expression, which can lead to lactic acidosis. Biguanides, such as buformin, are reported to inhibit the mitochondrial respiratory complex I by inhibiting ubiquinone reduction and by stimulating reactive oxygen species production via the complex I flavin. Some biguanides, including buformin, can also inhibit the mitochondrial ATP synthase. Buformin has also been examined for antitumor activity due to its ability to disrupt the unfolded protein response transcription program during glucose deprivation, which induces cell death in glucose-deprived tumor cells.

Chemische Eigenschaften

White Solid

Verwenden

BuforMin Hydrochloride is a biguanide derivative with antihyperglycemic activity. It delays absorption of glucose from the gastrointestinal tract, increases insulin sensitivity and glucose utilization in peripheral cells, and inhibits hepatic gluconeogenesis. BuforMin Hydrochloride has also been examined for antitumor activity due to its ability to disrupt the unfolded protein response transcription program during glucose deprivation, which induces cell death in glucose-deprived tumor cells.

1-Butylbiguanidmonohydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


1-Butylbiguanidmonohydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 122)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19936 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49979 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29792 58
TargetMol Chemicals Inc.
+1-781-999-5354; +17819995354
marketing@targetmol.com United States 32466 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167
1026@dideu.com China 9996 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207
sales@molcore.com China 49734 58
LY Global chemicals co.,ltd .
+8618939937369
info@lychems.cn China 969 58
HANGZHOU LEAP CHEM CO., LTD.
+86-571-87711850
market18@leapchem.com China 43333 58
Shanghai Acmec Biochemical Technology Co., Ltd.
+86-18621343501; +undefined18621343501
product@acmec-e.com China 33324 58
Aladdin Scientific

tp@aladdinsci.com United States 57505 58

1190-53-0(1-Butylbiguanidmonohydrochlorid)Verwandte Suche:


  • 1-Butylbigyanidine hydrochloride
  • 1-Butylbiguanide Hydrochloride
  • N-ButylidodicarboniMidic DiaMide Hydrochloride
  • PanforMin
  • Sindiatil
  • TideMol
  • Ziavetine
  • Adebit
  • Aids126511
  • Aids-126511
  • Andere
  • Biforon
  • Biguanide, 1-butyl-, hydrochloride
  • BUFORMINE HCL
  • BUFORMINE HYDROCHLORIDE
  • N-BUTYL BIGUANIDE HYDROCHLORIDE
  • 1-butylbiguanide monohydrochloride
  • n-butylbiguanideHCl
  • 1-Butyl-3-carbamimidoyl-guanidine hydrochloride
  • Buformin hydrochloride (JAN)
  • Dibetos-B (TN)
  • N-butylimidodicarbonimidic diamide hydrochloride
  • buformin hydrochloride
  • Buformin hydrochloride solution in Methanol,100μg/mL
  • BuforMin Hydrochloride USP/EP/BP
  • Buformin HclQ: What is Buformin Hcl Q: What is the CAS Number of Buformin Hcl Q: What is the storage condition of Buformin Hcl Q: What are the applications of Buformin Hcl
  • Imidodicarbonimidic diamide, N-butyl-, hydrochloride (1:1)
  • NSC 528218
  • NSC528218
  • NSC-528218
  • BUTYL-BIGUANIDE HYDROCHLORIDE
  • agent,Type II diabete,inhibit,Buformin hydrochloride,Inhibitor,SKBR3,cervical cancer,breast cancer,AMPK,biguanide analog,BT474,1-Butylbiguanide,antidiabetic,AMP-activated protein kinase,Buformin
  • N-Butylbiguanide Hydrochloride v
  • Buformin hydrochloride >=98% (HPLC)
  • Buformin Hydrochloride in Methanol
  • Buformin hydrochloride, 10 mM in DMSO
  • Buformin monohydrochloride
  • Buformin hydrochloride (Standard)
  • 1190-53-0
  • C6H16ClN5
  • C6H15N5HCl
  • Amines
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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