TOPOTECAN-D6
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- CAS-Nr.
- 1044904-10-0
- Englisch Name:
- TOPOTECAN-D6
- Synonyma:
- Hycamtin-d6;TOPOTECAN-D6;NSC-609669-d6;SKF-104864A-d6;[2H6]-Topotecan;D6-Topotecan dihydrochloride;Topotecan dihydrochloride salt;Topotecan-[D6] Dihydrochloride (Standard);(4S)-10-[[Di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[346-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(4S)-10-[(Dimethylamino-d6)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3’,4’,6-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- CBNumber:
- CB0649948
- Summenformel:
- C23H23N3O5
- Molgewicht:
- 421.45
- MOL-Datei:
- 1044904-10-0.mol
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TOPOTECAN-D6 Eigenschaften
- Schmelzpunkt:
- 213-218°C (dec)
- storage temp.
- -20°C Freezer
- L?slichkeit
- aqueous acid: soluble; DMSO: slightly; Methanol: soluble
- Aggregatzustand
- A solid
- Farbe
- Light yellow to yellow
- Stabilit?t:
- Hygroscopic
- CAS Datenbank
- 1044904-10-0
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H341 |
Kann vermutlich genetische Defekte verursachen. |
Keimzellmutagenit?t |
Kategorie 2 |
Warnung |
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P201,P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P308+P313 |
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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TOPOTECAN-D6 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Topotecan-d
6 is intended for use as an internal standard for the quantification of topotecan by GC- or LC-MS. Topotecan is an inhibitor of DNA topoisomerase I and a derivative of the DNA topoisomerase I inhibitor camptothecin . Topotecan inhibits DNA topoisomerase I in human MCF-7 breast and DU145 prostate cancer cells with IC
50 values of 13 and 2 nM, respectively, in a cell-based luciferase reporter assay. Topotecan induces cytotoxicity and DNA damage in HT-29 human colon adenocarcinoma cells (IC
50s = 33 and 280 nM, respectively). Formulations containing topotecan have been used in the treatment of small-cell lung cancer.
Chemische Eigenschaften
Light Yellow to Greenish Powder
Verwenden
Labelled Topotecan. A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic
TOPOTECAN-D6 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
TOPOTECAN-D6 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 34)Lieferanten
- TOPOTECAN-D6
- (4S)-10-[[Di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[346-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- SKF-104864A-d6
- (4S)-10-[(Dimethylamino-d6)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3’,4’,6-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- Hycamtin-d6
- NSC-609669-d6
- (4S)-10-[[Di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- [2H6]-Topotecan
- Topotecan dihydrochloride salt
- D6-Topotecan dihydrochloride
- Topotecan-[D6] Dihydrochloride (Standard)
- 1044904-10-0
- C23H17D6N3O5
- C23H17N3O5D6
- Heterocycles
- Isotope Labelled Compounds
- Inhibitors
- Intermediates & Fine Chemicals
- Isotope Labeled Compounds
- Pharmaceuticals
