Human Menopausal Gonadotrophin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Human Menopausal Gonadotrophin (HMG), also known as Menotropins, is a combination of FSH and LH extracted from the urine of postmenopausal women at a ratio of 1 : 1. HMG is a gonadotropin administered by intramuscular or subcutaneous injection for the treatment of infertility in women or men.
Verwenden
Gonad-stimulating
principle.
Allgemeine Beschreibung
Pituitary hormones prepared from the urine of postmenopausalwomen whose ovarian tissue does not respondto gonadotropin are available for medicinal use as theproduct menotropins (Pergonal). The latter has FSH andLH gonadotropin activity in a 1:1 ratio. Menotropins areuseful in the treatment of anovular women whose ovariesrespond to pituitary gonadotropins but who have a gonadotropindeficiency caused by either pituitary or hypothalamusmalfunction. Usually, menotropins are administeredintramuscularly in an initial dose of 75 IU of FSHand 75 IU of LH daily for 9 to 12 days, followed by 10,000IU of chorionic gonadotropin 1 day after the last dose ofmenotropins.
Mechanism of action
Human Menopausal Gonadotrophin (HMG), which contains follicle-stimulating hormone (FSH) and luteinizing hormone (LH), can secrete gonadotropin to promote follicle maturation to stimulate ovulation and accelerate the development of corpus luteum.HMG is derived from the urine of postmenopausal women[1].
Clinical Use
Menotropins are a natural product that is obtained from the urine of postmenopausal women and
then biologically standardized (international units [IU]) for FSH and LH activities in an
approximate ratio of 1:1. Menotropins are used in males with primary (hypothalamic) or
secondary (pituitary) hypogonadism to stimulate spermatogenesis, providing they have been
treated previously with human chorionic gonadotropin (hCG; a peptide hormone of placental
origin that has activity very similar to LH) to effect masculinization (increased
testosterone inducing ovulation in women who are having difficulty ovulating as a result of either
hypothalamic or pituitary hormonal dysfunction. The menotropins are given for 7 to 12 days, and
after clinical evaluation (via ultrasound) indicates the presence of a mature follicle, a single
dose of hCG is given to simulate the typical LH surge that normally triggers ovulation. Also,
women use the combination of menotropins and hCG to promote the development of multiple
follicles when they are participating in an IVF program requiring the recruitment of follicles.
Nebenwirkungen
Side effects: Headache, mild stomach pain/bloating, redness/pain at the injection site, breast tenderness, or dizziness may occur.
Serious side effects, including: vaginal bleeding, flu-like symptoms (such as fever, chills, joint pain, muscle ache, tiredness).
Human Menopausal Gonadotrophin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
