Balofloxacin
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- CAS-Nr.
- 127294-70-6
- Englisch Name:
- Balofloxacin
- Synonyma:
- q35;BALOFLOXACIN;Barlow of sand;BALOFLOXACIN 98.5%;Balofloxacin425.46;Balofloxacin, >=99%;Balofloxacin hydrate;Balofloxacin USP/EP/BP;Cypermethrin Impurity 4;Balofloxacin, 10 mM in DMSO
- CBNumber:
- CB0728838
- Summenformel:
- C20H24FN3O4
- Molgewicht:
- 389.42
- MOL-Datei:
- 127294-70-6.mol
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Balofloxacin Eigenschaften
- Schmelzpunkt:
- 137°C
- Siedepunkt:
- 608.3±55.0 °C(Predicted)
- Dichte
- 1.40±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- L?slichkeit
- H2O : < 0.1 mg/mL (insoluble)DMSO : 0.67 mg/mL (1.72 mM; Need ultrasonic)
- Aggregatzustand
- Solid
- pka
- 6.44±0.50(Predicted)
- Farbe
- White to off-white
- BRN
- 8362117
- InChI
- InChI=1S/C20H24FN3O4/c1-22-11-4-3-7-23(9-11)17-15(21)8-13-16(19(17)28-2)24(12-5-6-12)10-14(18(13)25)20(26)27/h8,10-12,22H,3-7,9H2,1-2H3,(H,26,27)
- InChIKey
- MGQLHRYJBWGORO-UHFFFAOYSA-N
- SMILES
- N1(C2CC2)C2=C(C=C(F)C(N3CCCC(NC)C3)=C2OC)C(=O)C(C(O)=O)=C1
- CAS Datenbank
- 127294-70-6(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H228 |
Entzündbarer Feststoff. |
Entzündbare Feststoffe |
Kategorie 1 |
Achtung
Warnung |
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P210, P240,P241, P280, P370+P378 |
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| Sicherheit |
| P403 |
An einem gut belüfteten Ort aufbewahren. |
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Balofloxacin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Balofloxacin, a novel orally-active fluoroquinolone antibiotic, was introduced in South
Korea for the treatment of urinary tract infections (UTI). It can be synthetized by reaction of
3-(methylamino)piperidine with the classical 4-quinolone-3-carboxylic acid template. In
vitro antibacterial activity of balofloxacin against gram-positive bacteria (Staphylococcus
aureus including methicillin-resistant S. aureus, Staphylococcus epidermis, Streptococcus
pneumonia, Streptococcus pyrogenes) was almost equal to that of sparfloxacin or
tosufloxacin, in contrast its activity against gram-negative bacteria was 2 times or more
lower. In clinical trials, balofloxacin was well tolerated and showed comparable efficacy to
ofloxacin in patients with UTls. After oral administration, balofloxacin was well absorbed,
and was primarily eliminated unchanged in the urine with an elimination half-life of
approximately 8 h. In animal studies, balofloxacin did not exhibit any phototoxicity.
Chemische Eigenschaften
Crystalline Solid
Verwenden
Balofloxacin is quinolone antibiotic, inhibiting the synthesis of bacterial DNA by interference with the enqyme DNA gyrase.
Pharmazeutische Anwendungen
A 6-fluoro-8-methoxy quinolone derivative. It has good antistaphylococcal activity (MIC 0.4–4 mg/L), but is inactive against methicillin-resistant Staph. aureus (MRSA) and quinolone-resistant Staph. aureus; Str. pneumoniae is inhibited by 0.4 mg/L. It has good activity against Enterobacteriaceae, but is inactive against Ps. aeruginosa (MIC 8–16 mg/L). After a 200 mg oral dose a peak level of 1.7 mg/L is reached in 1 h. The apparent elimination halflife is about 8 h, rising to 13 h in elderly subjects. Plasma protein binding is about 16%. It was withdrawn from the market in Japan because of adverse events, but is available in China.
Balofloxacin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Balofloxacin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 313)Lieferanten
127294-70-6()Verwandte Suche:
- 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-Methoxy-7-[3-(MethylaMino)-1-piperidinyl]-4-oxo-
- 1-Cyclopropyl-6-fluoro-8-Methoxy-7-(3-(MethylaMino)piperidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
- 1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-(methylamino)piperidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-c
- 1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-(methylamino)piperidin-1-yl)-4-oxo-1,4-dihydroquinoline-
- Balofloxacin, >=99%
- 1-cyclopropyl-6-fluoro-1,4- dihydro-8-methoxy-7-(3-methylaminopiperidin-1-yl)-4-oxoquinoline-3-carboxylic acid
- BALOFLOXACIN
- 3-quinolinecarboxylicacid,1,4-dihydro-1-cyclopropyl-6-fluoro-8-methoxy-7-(3-(
- q35
- BALOFLOXACIN 98.5% EXTRA PURE
- BALOFLOXACIN 98.5%
- Balofloxacin 1-cyclopropyl-6-fluoro-1,4- dihydro-8-methoxy-7-(3-methylaminopiperidin-1-yl)-4-oxoquinoline-3 carboxylic acid 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-8-Methoxy-7-[3-(Methylamino)-1-Piperidino]-4-Oxo-3-Quinoline Carboxylic Acid(Balofloxacin)
- 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[3-(methylamino)-1-piperidino]-4-oxo-3-quinolinecarboxylicacid
- (±)-1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[3-(methylamino)piperidino]-4-oxo-3-quinolinecarboxylic Acid
- 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[3-(methylamino)-1-piperidinyl]-4-oxo-3-quinolinecarboxylic Acid
- 1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-methylamino-1-piperidyl)-4-oxo-quinoline-3-carboxylic acid
- 1-Cyclopropyl-6-fluoro-1,4- dihydro-8-methoxy-7-(3-methylaminopiperidin-1-yl)-4-oxoquinoline-3-carboxylic
- Balofloxacin hydrate
- Balofloxacin425.46
- Balofloxacin USP/EP/BP
- BalofloxacinQ: What is
Balofloxacin Q: What is the CAS Number of
Balofloxacin Q: What is the storage condition of
Balofloxacin Q: What are the applications of
Balofloxacin
- Barlow of sand
- Balofloxacin/1-Cyclopropyl-6-fluoro-1,4- dihydro-8-methoxy-7-(3-methylaminopiperidin-1-yl)-4-oxoquinoline-3-carboxylic acid
- 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-3-(methylamino)piperidin-1-yl-4-oxo-quinolin-3-carboxylic acid
- Cypermethrin Impurity 4
- Balofloxacin, 10 mM in DMSO
- 127294-70-6
- C20H24FN3O4
- C20H24FN3O42H2O
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Antibacterial
- White crystal powder
