1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamid
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- CAS-Nr.
- 35920-39-9
- Bezeichnung:
- 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamid
- Englisch Name:
- NECA
- Synonyma:
- NECA;D-NECA;744-96;765-21;B-744-96;NECA USP/EP/BP;NECA, adenosine agonist;5'-ETHYLCARBOXAMIDOADENOSINE;5’-EthylcarboxamidoAdenosine;Adenosine-5'-ethylcarboxamide
- CBNumber:
- CB0763077
- Summenformel:
- C12H16N6O4
- Molgewicht:
- 308.29
- MOL-Datei:
- 35920-39-9.mol
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1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamid Eigenschaften
- Schmelzpunkt:
- 229-231°C
- Dichte
- 1.87±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL Solutions may be stored for several days at 4°C.
- pka
- 12.93±0.70(Predicted)
- Aggregatzustand
- powder
- Farbe
- white
- Wasserl?slichkeit
- 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2mg/mL (Solutions may be stored for several days at 4 °C.)
DMSO: 14mg/mL (Solutions may be stored for several days at 4 °C.)
0.1 M HCl: 3.4mg/mL (Solutions may be stored for several days at 4 °C.)
H2O: insoluble
ethanol: soluble (Solutions may be stored for several days at 4 °C.)
- Stabilit?t:
- Hygroscopic
- InChI
- InChI=1/C12H16N6O4/c1-2-14-11(21)8-6(19)7(20)12(22-8)18-4-17-5-9(13)15-3-16-10(5)18/h3-4,6-8,12,19-20H,2H2,1H3,(H,14,21)(H2,13,15,16)/t6-,7+,8-,12+/s3
- InChIKey
- JADDQZYHOWSFJD-FLNNQWSLSA-N
- SMILES
- N1(C=NC2C(N)=NC=NC1=2)[C@H]1[C@H](O)[C@H](O)[C@@H](C(=O)NCC)O1 |&1:10,11,13,15,r|
- CAS Datenbank
- 35920-39-9
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
T+ |
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| R-S?tze: |
28 |
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| S-S?tze: |
22-26-36-45 |
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| RIDADR |
UN 2811 6.1/PG 2 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
VJ2232000 |
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| HazardClass |
6.1(a) |
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| PackingGroup |
I |
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| HS Code |
29349990 |
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| Speicherklasse |
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials |
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| Hazard Classifications |
Acute Tox. 2 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H300 |
Lebensgefahr bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 2 |
Achtung |
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P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R28:Sehr giftig beim Verschlucken.
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
Chemische Eigenschaften
White Solid
Verwenden
A potent adenosine receptor agonist. Inhibits platelet aggregation and is centrally active in vivo
Definition
ChEBI: A derivative of adenosine in which the 5'-hydroxymethyl group is replaced by an N-ethylcarboxamido group.
Allgemeine Beschreibung
A cell-permeable adenosine analog that acts a potent non-selective agonist of adenosine receptors (K
i = 14 nM, 20 nM, 2.4 μM and 6.2 nM for A
1, A
2A, A
2B, A
3, respectively). Increases intracellular cAMP production (EC
50 = 3.1 μM in A
2B expressing CHO cells). Shown to increase glucagon release in a dose-dependent manner and inhibit insulin release at low concentrations. Although at higher concentration some insulin release is observed. Also, displays a wide range adenosine-dependent effects, such as blocking platelet aggregation and inhibiting DNA synthesis. When administered at reperfusion, it is shown reduce infarction and block the formation of the mitochondrial permeability transition pore by activating p70S6 kinase.
Biologische Aktivit?t
Potent adenosine receptor agonist (K i values are 14, 20 and 6.2 nM for human A 1 , A 2A and A 3 receptors respectively; EC 50 = 2.4 μ M for human A 2B ). Inhibits platelet aggregation and is centrally active in vivo .
1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 134)Lieferanten
35920-39-9(1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamid)Verwandte Suche:
- 5'-N6-Ethylcarboxamidoadenosine
- 5'-ETHYLCARBOXAMIDOADENOSINE
- 1-(6-AMINO-9H-PURIN-9-YL)-1-DEOXY-N-ETHYL-BETA-D-RIBOFURANURONAMIDE
- 1-(6-amino-9h-purin-9-yl)-1-deoxy-n-ethylribofuranuronamidehemihydrate
- 1-(6-amino-9h-purin-9-yl)-1-deoxy-n-ethyl-ribofuranuronamidhemihydrate
- 5’-n(sup6)-ethylcarboxamidoadenosinehemihydrate
- 5’-n-ethylcarboxamidoadenosinehemihydrate
- adenosine-5’-(n-ethyl)carboxamidehemihydrate
- adenosine-5’-(n-ethylcarboxamide
- NECA
- b-D-RibofuranuronaMide, 1-(6-aMino-9H-purin-9-yl)-1-deoxy-N-ethyl-
- D-NECA
- NECA,5′-(N-Ethylcarboxamido)adenosine
- Adenosine Receptor Agonist, NECA
- 5'-(N-ETHYLCARBOXAMIDO)-ADENOSINE
- 1-(6-Amino-(9H)-purin-9-yl)-1-deoxy-N-ethyl-b-D-ribofuranuronamide
- NECA, 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-D-ribofuranuronamide
- 5'-Ethylcarboxamido-D-adenosine
- 5'-N-Ethylcarboxamideadenosine
- 744-96
- 765-21
- Adenosine-5'-ethylcarboxamide
- B-744-96
- 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-β-D-ribofuranuronamide
- N-ethyl-5'-carboxamidoadenosine
- Adenosine Receptor Agonist, NECA - CAS 35920-39-9 - Calbiochem
- β-D-Ribofuranuronamide, 1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-
- NECA USP/EP/BP
- 5’-EthylcarboxamidoAdenosine
- 5'-N-Ethylcarboxamidoadenosine
- 5'-N-Ethylcarboxamidoadenosine (NECA)
- (2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,4-dihydroxytetrahydrofuran-2-carboxamide
- NECA, adenosine agonist
- 5''-N-Ethylcarboxamidoadenosine, 10 mM in DMSO
- 2-amino-4-(2,3-diethoxyphenyl)-7-methyl-5-oxo-6-(2-phenylethyl)-5,6-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile
- 35920-39-9
- C12H16N6O4
- Potent adenosine receptor agonist with nearly equal affinity at A1 and A2 receptors.
- Bases & Related Reagents
- Inhibitors
- Nucleotides
- Adenosine receptor
