Heptanoic acid, 7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
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- CAS-Nr.
- 2225940-50-9
- Englisch Name:
- Heptanoic acid, 7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
- Synonyma:
- UUN 40509;Pomalidomide-C6-COOH;Thalidomide-NH-C6-COOH;Thalidomide-4-NH-C6-COOH;Pomalidomide 4'-alkylC6-acid;Pomalidomide-C6-CO2H;Pomalidomide-C-6-COOH,PomalidomideC6COOH,Pomalidomide C6 COOH;7-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]heptanoic Acid;7-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]amino]heptanoic Acid;7-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)heptanoic acid
- CBNumber:
- CB08194529
- Summenformel:
- C20H23N3O6
- Molgewicht:
- 401.41
- MOL-Datei:
- 2225940-50-9.mol
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Heptanoic acid, 7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Eigenschaften
- Siedepunkt:
- 713.4±60.0 °C(Predicted)
- Dichte
- 1.409±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 4.77±0.10(Predicted)
- Aggregatzustand
- Solid
- Farbe
- Light yellow to yellow
- InChI
- 1S/C20H23N3O6/c24-15-10-9-14(18(27)22-15)23-19(28)12-6-5-7-13(17(12)20(23)29)21-11-4-2-1-3-8-16(25)26/h5-7,14,21H,1-4,8-11H2,(H,25,26)(H,22,24,27)
- InChIKey
- USOIUAJFCJMMOE-UHFFFAOYSA-N
- SMILES
- O=C1N(C2CCC(NC2=O)=O)C(C3=C1C=CC=C3NCCCCCCC(O)=O)=O
Sicherheit
| WGK Germany |
WGK 3 |
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| Speicherklasse |
11 - Combustible Solids |
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Heptanoic acid, 7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Protein degrader builiding block Pomalidomide-C
6-CO
2H enables the synthesis of molecules for
targeted protein degradation and
PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and an alkyl-chain crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.
When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Heptanoic acid, 7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Heptanoic acid, 7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 54)Lieferanten
- Heptanoic acid, 7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
- Pomalidomide-C6-COOH
- 7-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)heptanoic acid
- UUN 40509
- Pomalidomide-C-6-COOH,PomalidomideC6COOH,Pomalidomide C6 COOH
- Thalidomide-NH-C6-COOH
- 7-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]heptanoic Acid
- 7-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)heptanoic acid, Crosslinker?E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader
- Thalidomide-4-NH-C6-COOH
- 7-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]amino]heptanoic Acid
- Pomalidomide 4'-alkylC6-acid
- 7-[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]heptanoic acid
- Pomalidomide-C6-CO2H
- 7-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]heptanoic acid
- 2225940-50-9
