Temoporfin
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- CAS-Nr.
- 122341-38-2
- Englisch Name:
- Temoporfin
- Synonyma:
- MTHPC;3,3',3'',3'''-(7H,8H-Porphyrin-5,10,15,20-tetrayl)tetraphenol;EF 9;Foslip;Fosgel;Foscan;Fospeg;KW2345;Foslipos;m-TrTHPC
- CBNumber:
- CB0855310
- Summenformel:
- C44H32N4O4
- Molgewicht:
- 680.75
- MOL-Datei:
- 122341-38-2.mol
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Temoporfin Eigenschaften
- Schmelzpunkt:
- >250 °C
- Dichte
- 1.386±0.06 g/cm3(Predicted)
- storage temp.
- Amber Vial, -20°C Freezer, Under inert atmosphere
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- Farbe
- Purple
- InChIKey
- LYPFDBRUNKHDGX-LWQDQPMZSA-N
- SMILES
- C1(C2C=CC=C(O)C=2)=C2N=C(C(C3C=CC=C(O)C=3)=C3NC(=C(C4C=CC=C(O)C=4)C4=NC(=C(C5C=CC=C(O)C=5)C5NC1=CC=5)C=C4)C=C3)CC2 |c:20,t:8,23,35|
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
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P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P272 |
Kontaminierte Arbeitskleidung nicht au?erhalb des Arbeitsplatzes tragen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P321 |
Besondere Behandlung |
| P333+P313 |
Bei Hautreizung oder -ausschlag: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P363 |
Kontaminierte Kleidung vor erneutem Tragen waschen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Temoporfin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Temoporphin, a second generation
photosensitizer, was launched in UK for the photodynamic therapy
(PDT) of advanced head and neck
cancers. This porphyrin derivative can
be synthesized from pyrrole and 3-hydroxybenzaldehyde. The pharmacological activity is
initiated, 4 days after intravenous injection, by laser-light photoactivation of temoporphin,
that has selectively accumulated in cancer tissues. The resulting generation of highly
reactive oxygen species leads to malignant cells death thereby inducing tumor necrosis up
to a depth of 15 mm. An advantage of temoporphin over other photosensitizing agents is
its extreme sensitivity to wavelengths of light that penetrate tissues, resulting in lower
light/dose and irradiation time. PDT with intravenous temoporphin has produced relatively
high complete and partial response rates in head and neck cancers, with higher response
rates generally observed with higher light dose. Temoporphin is well-tolerated and does
not preclude surgery/radiotherapy as a later option. Adverse effects were photosensitivity
and pain at the injection site.
Verwenden
Temoporfin is a synthetic chlorin with light-activated actions. When administered systemically, temoporfin accumulates in tumor cells. When stimulated with light (650-652 nm) in the presence of oxygen, reactive oxygen species are generated, leading to necrosis within the tumor. Different approaches to using photodynamic therapy with temoporfin in palliative care are currently of interest.
Temoporfin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Temoporfin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 109)Lieferanten
122341-38-2()Verwandte Suche:
29H,31H-Phthalocyanin
(2S-trans)-18-Carboxy-20-(carboxymethyl)-13-ethyl-2,3-dihydro-3,7,12,17-tetramethyl-8-vinyl-21H,23H-porphin-2-propionsure
5,10,15,20-Tetraphenyl-21H,23H-porphin
Temozolomide
21H,23H-Porphin
Hydroxyphenyl
ETHYL-BIS-(SODIUMTETRAZOYLAZO)ACETATE
- TeMoporfin(KW-2345,EF9)
- EF 9
- Foscan
- Fosgel
- Foslip
- Foslipos
- Fospeg
- 2, 3-dihydro-5,10,15,20-tetra(m-hydroxyphenyl)porphyrin
- 3,3',3'',3'''-(2,3-dihydroporphyrin
-5,10,15,20-tetrayl) tetraphenol
- 5,10,15,20-tetra(hydroxyphenyl)chlorin
- m-TrTHPC
- Temoporphin
- temoporfin
- 8-dihydroporphyrin-5
- 5,10,15,20-tetra(m-hydroxyphenyl)chlorin
- 3,3',3'',3'''-(7,8-dihydroporphyrin-5,10,15,20-tetrayl)tetraphenol
- Phenol,3,3',3'',3'''-(7,8-dihydro-21H,23H-porphine-5,10,15,20-tetrayl)tetrakis-
- Temoporfin (m-THPC)
- Temoporfin(KW-2345)
- KW2345
- Temoporfin, 10 mM in DMSO
- Temoporfin 95%min
- 3,3',3'',3'''-(7H,8H-Porphyrin-5,10,15,20-tetrayl)tetraphenol
- MTHPC
- 122341-38-2
- C44H32N4O4
