Selamectin
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- CAS-Nr.
- 220119-17-5
- Englisch Name:
- Selamectin
- Synonyma:
- Skudin;Siratine;Silamycin;Stronghold;Selamectin;Serramycin;Selamection;Seragliptin;Selamectin（b）;Selamectin CRS
- CBNumber:
- CB0947411
- Summenformel:
- C43H63NO11
- Molgewicht:
- 769.97
- MOL-Datei:
- 220119-17-5.mol
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Selamectin Eigenschaften
- Schmelzpunkt:
- >180°C
- Siedepunkt:
- 917.0±65.0 °C(Predicted)
- Dichte
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- L?slichkeit
- Chloroform (Slightly), Dichloromethane (Slightly, Heated), DMSO (Slightly)
- Aggregatzustand
- Solid
- pka
- 10.34±0.70(Predicted)
- Farbe
- White to Yellow
- Stabilit?t:
- Hygroscopic
- InChIKey
- AFJYYKSVHJGXSN-KAJWKRCWSA-N
- CAS Datenbank
- 220119-17-5
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| HS Code |
2932206000 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Aquatic Chronic 4 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H413 |
Kann für Wasserorganismen sch?dlich sein, mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 4 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Selamectin Chemische Eigenschaften,Einsatz,Produktion Methoden
Application
Selamectin is formulated as a spot-on for cats and dogs
to control fleas (Ctenocephalides spp.) and flea-allergy
dermatitis, to prevent heartworm disease, and to control
ear mites (Otodectes cynotes) in cats and dogs. It is also
approved for the treatment and control of sarcoptic mange
(Sarcoptes scabiei) in dogs and hookworms (Ancylostoma
tubaeformis) and roundworms (Toxocara cati) in cats.
Verwenden
Selamectin is a topical parasiticide and also used as a veterinary antihelminithic agent on animals.
Hazard
Selamectin is a veterinary drug for the prevention or treatment of internal and external parasites in cats and dogs and is not approved for use in humans. It is a very safe drug, but overdose or accidental exposure may result in poisoning. In rare cases, humans may experience skin reactions such as hives, itching and redness of the skin.
Mechanism of action
Selamectin is a semi-synthetic avermectin that belongs to the class of macrolides. These drugs are neurotoxic to the parasite by enhancing glutamate-gated chloride ion channels in the parasite. The parasite becomes paralysed and dies due to increased permeability of chloride ions and hyperpolarisation of nerve cells. These drugs also potentiate other chloride channels, including those gated by gamma-aminobutyric acid (GABA). Mammals are usually unaffected because they lack glutamate-gated chloride channels and have a lower affinity for other mammalian chloride channels. Since these drugs do not normally penetrate the blood-brain barrier, GABA-gated channels in the mammalian CNS are not affected. Following topical administration, Selamectin has a high affinity for sebaceous glands and skin.
Synthese
A new synthesis process of selamectin is using doramectin as a starting material, and obtaining selamectin via hydrogenation, oxidation, oximation and desugaring.
Toxicity evaluation
Acute oral LD
50 for rats: >1,600 mg/kg
Selamectin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Selamectin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 261)Lieferanten
220119-17-5()Verwandte Suche:
- Selamectin
- AverMectin A1a,25-cyclohexyl-4'-O-de(2,6-dideoxy-3-O-Methyl-a-L-arabino-hexopyranosyl)-5-deMethoxy-25-de(1-Methylpropyl)-22,23-dihydro-5-(hydroxyiMino)-,(5Z)-
- hypnocarpic acid
- (5Z)-25-Cyclohexyl-4'-O-de(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)-avermectin A1a
- Revolution (antibiotic)
- Stronghold
- Selamectin CRS
- Avermectin A1a, 25-cyclohexyl-4'-O-de(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)-, (5Z)-
- Oxaliplatin Impurity5（EP Impurity D）
- selamectin ceutical
- Avermectin A1a, 25-cyclohexyl-4-O-de(2,6-dideoxy-3-O-methyl-...
- Selamection
- Selamectin (1611729)
- Sierra rhzomorph
- Skudin
- (2R,2a'E,2a1'S,4'E,5S,6S,6'S,7'S,8'E,11'R,15'S,17a'R,20'Z,20a'R)-6-Cyclohexyl-2a1'-hydroxy-7'-(((2R,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-20'-(hydroxyimino)-5,6',8',19'-tetramethyl-2a1',3,4,5,6,6',7',10',11',14',15',17a',20',20a'-tetradecahydro-2'H,17'H-spiro[pyran-2,13'-[11,15]methano[1,5]dioxacyclooctadecino[9,8,7-cd]benzofuran]-17'-one
- Selamectin（b）
- Seragliptin
- Silamycin
- Siratine
- Serramycin
- Selamectin in methanol
- Selamectin, 10 mM in DMSO
- Selamectin Solution
- Selamectin 100 μg/mL in Acetonitrile
- 220119-17-5
- C43H63NO11
- Anthelmintic
- ectoparasiticide
- API
- 220119-17-5
