PLERIXAFOR
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- CAS-Nr.
- 110078-46-1
- Englisch Name:
- PLERIXAFOR
- Synonyma:
- AMD310;CS-269;Mozobil;AMD-3329;Plerixafo;PLERIXAFOR;Sdz sid 791;Unii-S915p5499n;MOZOBIL PLERIXAFOR;Plerixafor(AMD3100)
- CBNumber:
- CB11011749
- Summenformel:
- C28H54N8
- Molgewicht:
- 502.78
- MOL-Datei:
- 110078-46-1.mol
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PLERIXAFOR Eigenschaften
- Schmelzpunkt:
- 122-125°C
- Siedepunkt:
- 657.5±55.0 °C(Predicted)
- Dichte
- 0.962
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- L?slichkeit
- Methanol (Slightly), Water (Slightly)
- Aggregatzustand
- Solid
- pka
- 10.60±0.20(Predicted)
- Farbe
- White to Pale Beige
- Stabilit?t:
- Hygroscopic
- Major Application
- pharmaceutical
- InChI
- InChI=1S/C28H54N8/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36/h5-8,29-34H,1-4,9-26H2
- InChIKey
- YIQPUIGJQJDJOS-UHFFFAOYSA-N
- SMILES
- C1(CN2CCCNCCNCCCNCC2)=CC=C(CN2CCCNCCNCCCNCC2)C=C1
- CAS Datenbank
- 110078-46-1
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| HS Code |
29339900 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P321 |
Besondere Behandlung |
| P332+P313 |
Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P362 |
Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen. |
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PLERIXAFOR Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Autologous hematopoietic stem cell (HSC) transplantation, a standard
treatment for hematological malignancies, such as non-Hodgkin’s lymphoma or multiple myeloma, involves collection of HSCs from the
patient, chemo- or radiotherapy of the patient to eliminate malignant cells,
and retransplantation of the stored HSCs.
Plerixafor is a potent antagonist of the CXCR4 chemokine receptor and a first-in-class drug for stem cell mobilization. CXCR4
is specific for stromal-derived-factor-1 (SDF-1), a molecule endowed with
potent chemotactic activity forlymphocytes. Because the interaction between
SDF-1 and CXCR4 plays an important role in holding HSCs in the bone
marrow, drugs that block the activity of CXCR4 receptor are capable of
mobilizing HSCs into the bloodstream. In vitro, plerixafor potently blocks
SDF-1 binding of CXCR4 and inhibits SDF-1-induced calcium flux
(IC
50 = 0.01-0.13 mg/mL) and chemotaxis (IC
50 = 0.13 mg/mL) in several
different cell types.
Plerixafor, in combination with G-CSF, is specifically
indicated to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin’s lymphoma and multiple myeloma.
Chemische Eigenschaften
White Solid
Nebenwirkungen
The most common adverse reactions (occurring in more than 10% of patients) observed during plerixafor use include diarrhea, nausea, fatigue, injection-site reactions, headache, arthralgia, dizziness, and vomiting.
PLERIXAFOR Upstream-Materialien And Downstream Produkte
Upstream-Materialien
1-(4,8-bis-(2,2,2-trifluoroacetyl)-11-{4-[4,8,11-tris-(2,2,2-trifluoroacetyl)-1,4,8,11-tetraazacyclotetradec-1-ylMethyl]-benzyl}-1,4,8,11-tetraazacyclotetradec-1-yl)-2,2,2-trifluoroethanone
592516-98-8
Kaliumcarbonat
Methanol
Downstream Produkte
PLERIXAFOR Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 329)Lieferanten
110078-46-1()Verwandte Suche:
- 1,1'-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane
- 1,4,8,11-Tetraazacyclotetradecane, 1,1'-(1,4-phenylenebis(methylene))bis-
- Mozobil
- Sdz sid 791
- Unii-S915p5499n
- 1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane
- Plerixafor(AMD3100)
- 1-{[4-(1,4,8,11-tetraazacyclotetradecan-1-ylMethyl)phenyl]Methyl}-1,4,8,11-tetraazacyclotetradecane
- MOZOBIL PLERIXAFOR
- plerixafor, AMD 3100, AMD-3100, AMD3100, JLK 169, Mozobil, 1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylMethyl)phenyl] Methyl]-1,4,8,11-tetrazacyclotetradecane
- PLERIXAFOR
- Plerixafor/JM3100/AMD3100
- 1,4-bis((1,4,8,11-tetraazacyclotetradecan-1-yl)Methyl)benzene
- 1,4-Bis((1,4,8,11-tetraazacyclotetradecan-1-yl)Methyl)benzene,95+%
- AMD3100 (Plerixafor)
- AMD310
- CS-269
- 1;4;8;11-TETRAAZACYCLOTETRADECANE; 1;1'-[1;4-PHENYLENEBIS(METHYLENE)]BIS;AMD 3100;AMD-3100
- 11-Tetraazacyclotetradecane
- 4-phenylenebis(methylene)]bis
- AMD-3329
- PLERIXAFOR USP/EP/BP
- Plerixafo
- Plerixafor (125 mg)
- 1,4-Bis((1,4,8,1-tetrazacyclodecatetralkane-1-yl)methyl)benzene
- 110078-46-1
- C28H66Br8N8O2
- Aromatics
- Heterocycles
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- API
