NSC632839hydrochloride
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- CAS-Nr.
- 157654-67-6
- Englisch Name:
- NSC632839hydrochloride
- Synonyma:
- NSC 632839;NSC632839 HCl;NSC 632839 ，S4922;NSC 632839;NSC-632839;NSC632839hydrochloride;NSC632839, 10 mM in DMSO;Ubiquitin Isopeptidase Inhibitor II;Ubiquitin Isopeptidase Inhibitor II, F6;NSC-632839, ubiquitin isopeptidase inhibitor;3,5-Bis(4-methylbenzylidene)piperidin-4-one hydrochloride
- CBNumber:
- CB11075088
- Summenformel:
- C21H21NO.ClH
- Molgewicht:
- 339.864
- MOL-Datei:
- 157654-67-6.mol
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NSC632839hydrochloride Eigenschaften
- storage temp.
- Store at +4°C
- L?slichkeit
- DMSO: ≥2mg/mL (warmed)
- Aggregatzustand
- powder
- Farbe
- faint yellow to dark yellow
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
- InChI
- 1S/C21H21NO.ClH/c1-15-3-7-17(8-4-15)11-19-13-22-14-20(21(19)23)12-18-9-5-16(2)6-10-18;/h3-12,22H,13-14H2,1-2H3;1H/b19-11+,20-12+;
- InChIKey
- ZOKZLTXPTLIWOJ-BYCVLTJGSA-N
- SMILES
- Cl.Cc1ccc(cc1)\C=C2/CNC\C(=C/c3ccc(C)cc3)C2=O
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi,N |
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| R-S?tze: |
36-51/53 |
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| S-S?tze: |
26-61 |
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| RIDADR |
UN 3077 9 / PGIII |
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| WGK Germany |
3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Eye Irrit. 2 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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NSC632839hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Protein ubiquitination is a dynamic process that can be reversed by deubiquitinating enzymes (DUBs) that remove ubiquitin from proteins, sparing them from degradation by the proteasome. The DUBs have been divided into various groups, the largest being the ubiquitin-specific proteases (USPs). NSC 632839 inhibits USP2 and USP7 as well as the ubiquitin-like SUMO peptidase SENP2 with EC50 values of 45, 37, and 9.8 μM, respectively. It is reported to inhibit apoptosis through a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC50 = 15.7 μM in cells sensitized by E1A, an adenoviral oncogene).
Biologische Aktivit?t
Inhibitor of ubiquitin isopeptidase activity that displays no effect on the proteolytic activity of the proteasome. Induces apoptosis via a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC 50 values are 15.65 and 16.23 μ M in E1A and E1A/C9CN cells respectively).
NSC632839hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
NSC632839hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 123)Lieferanten
157654-67-6()Verwandte Suche:
- Ubiquitin Isopeptidase Inhibitor II, F6
- NSC 632839
- 4-Piperidione,3,5-bis[(4-methylphenyl)methylene] hydrochloride
- NSC632839hydrochloride
- 3,5-Bis[(4-methylphenyl)methylene]-4-piperidonehydrochloride
- NSC 632839;NSC-632839
- Ubiquitin Isopeptidase Inhibitor II
- NSC632839 HCl
- 3,5-Bis(4-methylbenzylidene)piperidin-4-one hydrochloride
- 4-Piperidinone, 3,5-bis[(4-methylphenyl)methylene]-, hydrochloride (1:1)
- NSC-632839, ubiquitin isopeptidase inhibitor
- NSC632839, 10 mM in DMSO
- NSC 632839 ，S4922
- 157654-67-6
- C21H21NOHCl
