Tiplaxtinin
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- CAS-Nr.
- 393105-53-8
- Englisch Name:
- Tiplaxtinin
- Synonyma:
- tiplasinin;CS-1464;PAI-039;Tiplaxtinin;PAI 039 Tiplaxtinin;TIPLAXTININ(PAI-039);Tiplaxtinin >=98% (HPLC);Tiplaxtinin(PAI-039), >98%;TIPLAXTININ;PAI039;PAI 039;Tiplaxtinin, 10 mM in DMSO
- CBNumber:
- CB11261085
- Summenformel:
- C24H16F3NO4
- Molgewicht:
- 439.38
- MOL-Datei:
- 393105-53-8.mol
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Tiplaxtinin Eigenschaften
- Schmelzpunkt:
- 164-167℃
- Dichte
- 1.34
- storage temp.
- -20°C
- L?slichkeit
- DMSO (Sparingly), Methanol (Slightly)
- Aggregatzustand
- powder
- Farbe
- white to beige
- InChI
- InChI=1S/C24H16F3NO4/c25-24(26,27)32-18-9-6-16(7-10-18)17-8-11-21-19(12-17)20(22(29)23(30)31)14-28(21)13-15-4-2-1-3-5-15/h1-12,14H,13H2,(H,30,31)
- InChIKey
- ODXQFEWQSHNQNI-UHFFFAOYSA-N
- SMILES
- C1(C(=O)C(O)=O)=CN(C2C=CC(C3=CC=C(C=C3)OC(F)(F)F)=CC1=2)CC1C=CC=CC=1
Tiplaxtinin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Tiplaxtinin is an inhibitor of plasminogen activator inhibitor 1 (PAI-1; IC
50 = 2.7 μM for the human enzyme). It inhibits differentiation of human adipocytes when used at a concentration of 5 μM. Tiplaxtinin (5 and 20 mg/kg) reduces tumor growth and microvessel density in a T24 bladder cancer mouse xenograft model. It prevents carotid artery occlusion, increases the time to occlusive thrombosis, and decreases the thrombus size in a rat model of ferric chloride-induced arterial thrombosis when administered at a dose of 1 mg/kg.
Verwenden
Tiplaxtinin inhibits smooth muscle cells (SMC) migration and intimal hyperplasia. A novel therapeutic agent to improve diabetic wound.
Definition
ChEBI: Tiplasinin is a member of indole-3-acetic acids. It is a potent and selective PAI-1 inhibitor. Tiplaxtinin demonstrated efficacy in vivo in multiple models of acute arterial thrombosis and has been shown to reduce physiologic PAI-1 activity.
Biochem/physiol Actions
Tiplaxtinin has high oral bioavailability. It is metabolically stable and shows large safety multiples in animal toxicology studies. Tiplaxtinin can be easily synthesized in bulk quantities. This drug also reduces diet-induced obesity in mice.
Tiplaxtinin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Tiplaxtinin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 132)Lieferanten
393105-53-8()Verwandte Suche:
- 2-(1-benzyl-5-(4-(trifluoromethoxy)phenyl)-1H-indol-3-yl)-2-oxoacetic acid
- TIPLAXTININ(PAI-039)
- 1H-Indole-3-aceticacid, a-oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-
- 2-[1-benzyl-5-[4-(trifluoromethoxy)phenyl]indol-3-yl]-2-oxo-acetic aci d
- Tiplaxtinin
- PAI-039
- alpha-Oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-1H-indole-3-acetic acid
- PAI 039 Tiplaxtinin
- Tiplaxtinin(PAI-039), >98%
- α-Oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-1H-indole-3-acetic acid
- CS-1464
- TIPLAXTININ;PAI039;PAI 039
- 1H-Indole-3-acetic acid, α-oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-
- Tiplaxtinin >=98% (HPLC)
- Tiplaxtinin, 10 mM in DMSO
- tiplasinin
- 393105-53-8
- C24H16F3NO4
- Inhibitors
