Lomeguatrib
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- CAS-Nr.
- 192441-08-0
- Englisch Name:
- Lomeguatrib
- Synonyma:
- C521206;CS-1103;AI3 27596;BRN1861032;Lomeguatrib;Lomeguqtrib;BRN 1861032;BRN-1861032;Lomeguaritrib;Lomeguatrib 98%
- CBNumber:
- CB11261272
- Summenformel:
- C10H8BrN5OS
- Molgewicht:
- 326.17
- MOL-Datei:
- 192441-08-0.mol
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Lomeguatrib Eigenschaften
- Siedepunkt:
- 683.8±65.0 °C(Predicted)
- Dichte
- 2.07
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- L?slichkeit
- DMSO: soluble10mg/mL, clear
- pka
- 9.42±0.10(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
- InChI
- 1S/C10H8BrN5OS/c11-5-1-6(18-3-5)2-17-9-7-8(14-4-13-7)15-10(12)16-9/h1,3-4H,2H2,(H3,12,13,14,15,16)
- InChIKey
- JUJPKFNFCWJBCX-UHFFFAOYSA-N
- SMILES
- Nc1nc(OCc2cc(Br)cs2)c3nc[nH]c3n1
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
UO7420000 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Acute Tox. 4 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Lomeguatrib Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
O6-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein which removes an alkyl group from the O6 position on guanine in an autoinactivating reaction. Although important in normal DNA repair, this reaction confers resistance to treatments that use O6-alkylating agents to produce cytotoxicity, e.g., in cancer. Lomeguatrib is a modified quanine base which acts as a pseudosubstrate inactivator of MGMT (IC50 = ~3 nM). A non-toxic compound, lomeguatrib completely inactivates MGMT in human prostate and colorectal tumors when given as a single 120 mg oral dose and in primary central nervous system cancers at 160 mg.
Lomeguatrib Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Lomeguatrib Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 151)Lieferanten
192441-08-0()Verwandte Suche:
- Lomeguatrib
- 2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine
- 6-[(4-bromothiophen-2-yl)methoxy]-7H-purin-2-amine
- 6-((4-Bromo-2-thienyl)methoxy)purin-2-amine
- C521206
- 2-AMino-6-(4-broMothiophen-2-ylMethoxy)-9H-purine
- 6-[(4-BroMo-2-thienyl)Methoxy]
-1H-purin-2-aMine
- 6-[(4-BroMo-2-thienyl)Methoxy]-9H-purin-2-aMine
- LoMeguatrib(PaTrin-2)
- 2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine Lomeguatrib(PaTrin-2)
- 2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine Lomeguatrib
- Lomeguatrib
2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine
- Lomeguqtrib
- Lomeguaritrib
- Lomeguatrib, >=98%
- CS-1103
- PATRIN 2; PATRIN-2
- 9H-Purin-2-amine, 6-[(4-bromo-2-thienyl)methoxy]-
- Lomeguatrib USP/EP/BP
- 6-((4-Bromothiophen-2-yl)methoxy)-9H-purin-2-amine
- AI3 27596
- BRN 1861032
- BRN1861032
- BRN-1861032
- Lomeguatrib, MGMT inhibitor
- Lomeguatrib, 10 mM in DMSO
- Lomeguatrib 98%
- 192441-08-0
- C10H8BrN5OS
- Inhibitors
- Inhibitor of MGMT.
- Epigenetics
