2'-Desoxy-5-methylcytidin
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- CAS-Nr.
- 838-07-3
- Bezeichnung:
- 2'-Desoxy-5-methylcytidin
- Englisch Name:
- 5-Methyl-2'-deoxycytidine
- Synonyma:
- 5-Me-2'-dC;5-methyldeoxycytidine;5-mdC;5-Me-dC;5MedCyd;5-METHYL-DC;5-Methyl-2'-deoxycyt;Deoxy methylcytidine;5-Me-2'-deoxycytidine;2'-Deoxy-5-Mecytidine
- CBNumber:
- CB1132913
- Summenformel:
- C10H15N3O4
- Molgewicht:
- 241.24
- MOL-Datei:
- 838-07-3.mol
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2'-Desoxy-5-methylcytidin Eigenschaften
- Schmelzpunkt:
- 217-219 °C(lit.)
- Siedepunkt:
- 492.8±55.0 °C(Predicted)
- Dichte
- 1+-.0.1 g/cm3(Predicted)
- Brechungsindex
- 44 ° (C=1.4, H2O)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- L?slichkeit
- DMSO (Slightly, Heated), Methanol (Slightly, Heated), Water (Slightly)
- Aggregatzustand
- Powder
- pka
- pK1:4.33 (25°C)
- Farbe
- White to Off-white
- Optische Rotation
- 41.1°(C=0.009986 g/ml H2O)
- Wasserl?slichkeit
- Soluble in water.
- Stabilit?t:
- Hygroscopic
- InChI
- InChI=1S/C10H15N3O4/c1-5-3-13(10(16)12-9(5)11)8-2-6(15)7(4-14)17-8/h3,6-8,14-15H,2,4H2,1H3,(H2,11,12,16)/t6-,7+,8+/m0/s1
- InChIKey
- LUCHPKXVUGJYGU-XLPZGREQSA-N
- SMILES
- OC[C@H]1O[C@@H](N2C=C(C)C(N)=NC2=O)C[C@@H]1O
- CAS Datenbank
- 838-07-3(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
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| R-S?tze: |
36/37/38 |
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| S-S?tze: |
26-36-24/25 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
HA3860000 |
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| HS Code |
29389090 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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2'-Desoxy-5-methylcytidin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White Solid
Verwenden
5-Methyl-2'-deoxycytidine is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo DNA methylation. It has been used in epigenetics research to investigate the dynamics of DNA methylation pattern in the control of gene expression.
Allgemeine Beschreibung
Giel-Pietraszuk et al. developed a new method for quantification of 5-methyl-2'-deoxycytidine (m5C) in the DNA. The technique is based on the conversion of m5C into fluorescent 3, N4-etheno-5-methyl-2'-deoxycytidine (εm5C) and its identification by reversed-phase high-performance liquid chromatography (RP-HPLC)[1].The measurement of 5-meC and 5-medC in urine may help assess changes in DNA methylation status in the whole body and investigate the DNA demethylation mechanism in vivo. 5-MedC was first detected in urine using an inhibition ELISA method;12 however, because ELISA may suffer from poor selectivity and sensitivity, later urinary measurements of 5-medC were developed mainly based on the chromatographic techniques[2].
2'-Desoxy-5-methylcytidin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2'-Desoxy-5-methylcytidin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 304)Lieferanten
838-07-3(2'-Desoxy-5-methylcytidin)Verwandte Suche:
- 5-METHYL-DC
- 5-METHYL-2'-DEXOYCYTIDINE
- 4-AMINO-1-[(2R,4S,5R)-4-HYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-5-METHYL-PYRIMIDIN-2-ONE
- 2’-deoxy-5-methyl-cytidin
- 2'-Deoxy-5-methyl-D-cytidine
- 4-amino-1-[(2R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidin-2-one
- 2''-DEOXY-5-METHYLCYTIDINE (5-METHYL-2''-DEOXYCYTIDINE)
- 1-(2-Deoxy-beta-D-ribofuranosyl)-5-methylcytosine
- 5-Methyl-2'-deoxycyt
- Cytidine, 2'-deoxy-5-methyl-
- (2R,3R,4S,5R)-2-(4-aMino-5-Methyl-1,2-dihydropyriMidin-1-yl)-5-(hydroxyMethyl)oxolane-3,4-diol
- 4-AMino-1-(4-hydroxy-5-hydroxyMethyl-tetrahydro-furan-2-yl)-5-Methyl-1H-pyriMidin-2-one
- 4-AMino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-5-MethylpyriMidin-2(1H)-one
- 5-Me-dC
- 5-Methyl-2'-deoxycytidine Solution, 100ppm
- 5-Methyl-2'-deoxycytidine≥ 99% (HPLC)
- 5-Methyl-2'-deoxycytidine, >=99%
- 5-Me-2'-deoxycytidine
- 2'-Deoxy-5-methylcytidine, ≥99%(HPLC)
- 2'-Deoxy-5-Me-Cytidine
- Deoxy methylcytidine
- 2'-Deoxy-5-methylcytidine>
- 5MedCyd
- 5-mdC
- 5-Methyl-2'-deoxycytidine USP/EP/BP
- 5-methyl-2'-deoxycytidine(5-Me-dC)
- 5-Methyl-2'-deoxycytidine
- 2'-Deoxy-5-methylcytidine
- 2'-Deoxy-5-Mecytidine
- 5-Methyl-2''-deoxycytidine
- 5-Methyl-2''-deoxycytidine, 10 mM in DMSO
- 5-Methyl-2'-deoxycytidine
- 2'-Deoxy-5-methylcytidine
- Cytidine Impurity 3 (5-Methyl-2'-Deoxycytidine)
- 5-Me-2'-dC
- 5-methyldeoxycytidine
- 838-07-3
- C10H15N3O4
- Bases & Related Reagents
- Heterocycles
- Intermediates & Fine Chemicals
- Nucleotides
- Pharmaceuticals
- Biochemistry
- Nucleosides and their analogs
- Nucleosides, Nucleotides & Related Reagents
