146135-18-4
中文名稱
化合物 GW-841819X
英文名稱
CarbaMic acid, (1-Methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl)-, phenylMethyl ester (9CI)
CAS
146135-18-4
分子式
C25H21N5O2
分子量
423.467
MOL 文件
146135-18-4.mol
146135-18-4 結(jié)構(gòu)式
基本信息
中文別名
化合物 GW-841819X 英文別名
TUWDLUFFAHHNEF-UHFFFAOYSA-NCarbamic acid, N-(1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl)-, phenylmethyl ester
CarbaMic acid, (1-Methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl)-, phenylMethyl ester (9CI)
應(yīng)用領(lǐng)域
用途一
GW841819X is an analogue of (+)-JQ1 and a novel inhibitor of BET bromodomains. GW841819X displayed activity in vivo against NUT-midline carcinoma, multiple myeloma, mixed-lineage leukemia, and acute myeloid leukemia. Bromodomain and extra-terminal (BET) proteins belong to a class of proteins collectively called epigenetic "readers". BET bromodomains have emerged as promising drug targets for treatment of cancers, inflammatory diseases, and other medical conditions.