Fursultiamin
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- CAS-Nr.
- 804-30-8
- Bezeichnung:
- Fursultiamin
- Englisch Name:
- Fursultiamine
- Synonyma:
- ttfd;FURSULTIAMINE HYDROCHLORIDE;Fursutiamine;thiaminetetrahydrofurfuryldisulfide;judolor;linamin;Retar B1;adventan;diteftin;Alinaxin
- CBNumber:
- CB1161096
- Summenformel:
- C17H26N4O3S2
- Molgewicht:
- 398.54
- MOL-Datei:
- 804-30-8.mol
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Fursultiamin Eigenschaften
- Schmelzpunkt:
- 130-136°C (decompos.)
- Siedepunkt:
- 652.3±55.0 °C(Predicted)
- Dichte
- 1.29
- Brechungsindex
- 1.6270 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- L?slichkeit
- soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).
- Aggregatzustand
- Solid
- pka
- 14.42±0.10(Predicted)
- Farbe
- White to Off-White
- InChI
- InChI=1S/C17H26N4O3S2/c1-12(16(5-6-22)26-25-10-15-4-3-7-24-15)21(11-23)9-14-8-19-13(2)20-17(14)18/h8,11,15,22H,3-7,9-10H2,1-2H3,(H2,18,19,20)
- InChIKey
- JTLXCMOFVBXEKD-UHFFFAOYSA-N
- SMILES
- C(N(CC1=CN=C(C)N=C1N)C(C)=C(SSCC1CCCO1)CCO)=O
- CAS Datenbank
- 804-30-8(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Toxizit?t |
LD50 in rats (mg/kg): 2200 orally; 540 i.p. (Yurugi, Fushimi) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P304+P340 |
BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Fursultiamin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Fursultiamine (syn. thiamine tetrahydrofurfuryl disulfide) is a vitamin B1 derivative which is rarely used, is only sparingly soluble in water and thus is usually employed only for solid drug forms. Lyophilisates are stabilized by sodium dextran sulfate.
Chemische Eigenschaften
white or slightly yellow crystalline powder. melting point 130-136 °C (decomposition). soluble in methanol, ethanol, chloroform, slightly soluble in acetone, insoluble in benzene, ether, slightly garlic odor.
Verwenden
Fursultiamine is an oral source of thiamine, used in comparative pharmacokinectic analysis of thiamine and it’s phosphorylated metabolites administered as multivitamin preparations, identification of drug candidate against prostate cancer from aspect of somatic cell reprogramming, therapeutic tool in number of human neurological diseases.
Application
Fursultiamine, a lipophilic vitamin B1 derivative, which is more readily absorbed in large amounts in the small intestine and has a longer half-life than its active counterpart vitamin B1. It is suitable for the treatment of beriberi or Wernicke encephalopathy due to vitamin B1 deficiency. It can also be used for the adjuvant treatment of peripheral neuritis and indigestion caused by vitamin B1 deficiency.
synthetische
Furanthiamine is obtained by condensing thiamine hydrochloride with sodium tetrahydrofuranmethyl thiosulfate after ring opening.
Fursultiamin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Fursultiamin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 182)Lieferanten
804-30-8(Fursultiamin)Verwandte Suche:
- ((tetrahydrofurfuryl)dithio)-1-butenyl)-
- adventan
- alinaminf
- diteftin
- fursultiamin
- n-(4-amino-2-methylpyrimidin-5-ylmethyl)-n-[4-hydroxy-1-methyl- 2-(tetrahydrofurfuryldithio)but-1-enyl]formamide
- Formamide, N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[(tetrahydrofurfuryl)dithio]-1-butenyl]- (6CI, 8CI)
- Formamide, N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydro-2-furanyl)methyl]dithio]-1-butenyl]-
- N-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[(tetrahydrofurfuryl)dithio]-1-butenyl]formamide
- Retar B1
- Tetrahydrofurfuryl thiamine disulfide
- Thiamin tetrahydrofurfuryl disulfide
- N-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-N-[(E)-5-hydroxy-3-(oxolan-2-ylmethyldisulfanyl)pent-2-en-2-yl]formamide
- Fursultiamine (base and/or unspecified salts)
- N-(-4-amino-2-methyl-5-pyrimidinylmethyl)-N-(-4-hydroxyl-1-methyl-2-tetrahyclrofurfury(dithio-1-bute
- Fursultiamine###Fursultiamine Hcl
- FURSULTIAMINE
- Fursultiamine Base
- Fursultiaminlim
- N-(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydro-2-furanyl)methyl]dithio]-1-butenyl]forma
- Aliaron F
- Alinaxin
- N-[(2-Methyl-4-amino-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydrofuran-2-yl)methyl]dithio]-1-butenyl]formamide
- judolor
- linamin
- retar-b(sub1)
- Fursultiamine Hydrochloride RS
- Formamide, N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydro-2-furanyl)methyl]dithio]-1-buten-1-yl]-
- THIAMINE TETRAHYDROFURFURYL DISULFIDE (TTFD)
- Fursultiamine USP/EP/BP
- Fursultiamine HCL JP USP/EP/BP
- Derivative Fursultiamine
- N-((4-Amino-2-methylpyrimidin-5-yl)methyl)-N-(5-hydroxy-3-(((tetrahydrofuran-2-yl)methyl)disulfanyl)pent-2-en-2-yl)formamide
- Furan thiamine
- Fursultiamine, 10 mM in DMSO
- n-(4-amino-2-methylpyrimidin-5-ylmethyl)-n-[4-hydroxy-1-methyl- 2-(tetrahydrofurfuryldithio)but-1-enyl]formamid
- Fursutiamine
- FURSULTIAMINE HYDROCHLORIDE
- thiaminetetrahydrofurfuryldisulfide
- ttfd
- 804-30-8
- C17H26N4O3S2
- Vitamins and derivatives
