4-Acetyl-1-(β-D-ribofuranosyl)cytosin
|
|
|
- CAS-Nr.
- 3768-18-1
- Bezeichnung:
- 4-Acetyl-1-(β-D-ribofuranosyl)cytosin
- Englisch Name:
- N4-Acetylcytidine
- Synonyma:
- N-Acetylcytidine;Ac-rC;Acetylcytidine;rC(Ac);N4-Ac-Cr;N4-Ac-rC;ACETYL CYTOSINE;n-acetyl-cytidin;4-Acetylcytidine;N4-ACETYLCYTIDINE
- CBNumber:
- CB1207392
- Summenformel:
- C11H15N3O6
- Molgewicht:
- 285.25
- MOL-Datei:
- 3768-18-1.mol
|
4-Acetyl-1-(β-D-ribofuranosyl)cytosin Eigenschaften
- Schmelzpunkt:
- 199 °C (dec.)(lit.)
- Dichte
- 1.72±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- L?slichkeit
- DMSO (Slightly, Heated), Methanol (Slightly, Heated)
- pka
- 10.21±0.20(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to Pale Yellow
- PH
- ＜1.5
- maximale Wellenl?nge (λmax)
- 247，297 (pH 7)
- InChI
- InChI=1S/C11H15N3O6/c1-5(16)12-7-2-3-14(11(19)13-7)10-9(18)8(17)6(4-15)20-10/h2-3,6,8-10,15,17-18H,4H2,1H3,(H,12,13,16,19)/t6-,8-,9-,10-/m1/s1
- InChIKey
- NIDVTARKFBZMOT-PEBGCTIMSA-N
- SMILES
- OC[C@H]1O[C@@H](N2C=CC(NC(C)=O)=NC2=O)[C@H](O)[C@@H]1O
- CAS Datenbank
- 3768-18-1(CAS DataBase Reference)
- NIST chemische Informationen
- Cytidine, n-acetyl-(3768-18-1)
4-Acetyl-1-(β-D-ribofuranosyl)cytosin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
N4-Acetylcytidine is a modified nucleoside and endogenous urinary nucleoside product of the degradation of tRNA. N4-Acetylcytidine is a biological marker for various cancers with elevated concentrations present in urine. tRNA has been shown to be excreted in abnormal amounts in the urine of cancer patients. tRNA from neoplastic tissue had a much more rapid turnover rate than the tRNA from the corresponding normal tissue. Evidence indicates that methylation of tRNA occurs only after synthesis of the intact macromolecule. Because there are no specific enzyme systems to incorporate the modified nucleosides into the macromolecular nucleic acid, these nucleosides once released in the process of tRNA turnover cannot be reutilized, nor are they further degraded, but are excreted in urine.
N4-Acetylcytidine is also a partially protected cytidine and therefore can be used as a synthetic building block to prepare further derivatized nucleosides such as 2’,3’-dideoxycytidine.
Verwenden
N4-Acetylcytidine (cas# 3768-18-1) is a nucleotide-derived metabolite used as biomarkers for diagnosis of inflammation-related diseases.
Definition
ChEBI: N(4)-acetylcytidine is cytidine in which one of the exocyclic amino hydrogens is substituted by an acetyl group. It has a role as a metabolite. It is a member of cytidines, a member of acetamides and a secondary carboxamide.
4-Acetyl-1-(β-D-ribofuranosyl)cytosin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-Acetyl-1-(β-D-ribofuranosyl)cytosin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 242)Lieferanten
3768-18-1(4-Acetyl-1-(β-D-ribofuranosyl)cytosin)Verwandte Suche:
- 4-Acetyl-1-(beta-D-ribofuranosyl)cytosine
- ACETYL CYTOSINE
- N4-ACETYLCYTIDINE
- 4-Acetylcytidine
- Acetamide, N-(1,2-dihydro-2-oxo-1-beta-D-ribofuranosyl-4-pyrimidinyl)-
- n-acetyl-cytidin
- N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxo-pyrimidin-4-yl]ethanamide
- N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]-2-keto-pyrimidin-4-yl]acetamide
- N4-Acetyl-D-cytidine
- N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide
- N4 CACETYLCYTIDINE
- N(sup 4)-acetylcytidine
- N4-Acetylcytidine
- N4-Ac-Cr
- N4-Ac-rC
- N4-Acetylcytidine, 97.5%
- N4-Acetylcytidine, 97.5%
- Cytidine, N-acetyl-
- N4-Acetylcytidine USP/EP/BP
- Acetylcytidine
- Ac-rC
- N4-Acetyl cytidine,RNA modified nucleoside ac4C
- RNA modified nucleoside ac4C
- rC(Ac)
- Cytidine Impurity 1 (N4-Acetylcytidine)
- N4-Acetylcytidine, 10 mM in DMSO
- N'-ACETYLCYTIDINE
- N-Acetylcytidine
- 3768-18-1
- C11H15N3O6
- Nucleoside Analogs
- Nucleosides, Nucleotides, Oligonucleotides
- Biochemicals and Reagents
- BioChemical
- Biochemicals and Reagents
- Nucleoside Analogs
- Nucleosides, Nucleotides, Oligonucleotides
- Nucleic acids
- Modified（deoxy）nucleoside
