Anti-A4 Amyloid protein, Anti-ABETA, Anti-ABPP, Anti-AD1, Anti-Amyloid β A4 protein, Anti-Amyloid-β protein (ABP), Anti-APPI Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Rabbit anti-β-amyloid (22-35) antibody can be used for ELISA at a concentration of 0.2-0.4μg/mL using β-amyloid peptide (22-35). The product can also be used for western blot at 0.25-0.5μg/mL using β-amyloid peptide (1-40).
Allgemeine Beschreibung
Rabbit anti-β-amyloid (22-35) antibody specifically recognizes β-amyloid (22-35), β-amyloid (25-35), β-amyloid (1-40) and β-amyloid (1-42) and does not react with β-amyloid (32-35) and β-amyloid (35-25) by ELISA. The antibody detects β-amyloid (1-40) by immunoblotting (approx. 4kDa). Staining of the β-amyloid (1-40) band in immunoblotting is specifically inhibited by the immunizing peptide.
Biochem/physiol Actions
Secreted Aβ lead to synaptic and neuritic compromise and glial activation. Aggregates of amyloid β peptide are found deposited in the brains of Alzheimer′s patients. Aβ(25-35) and Aβ(22-35) fragments are highly toxic segments of β-amyloid peptides that promote inflammatory processes in astrocytes and fibrillary aggregation of Aβ, thus representing a promising therapeutic target for Alzheimer′s.
Anti-A4 Amyloid protein, Anti-ABETA, Anti-ABPP, Anti-AD1, Anti-Amyloid β A4 protein, Anti-Amyloid-β protein (ABP), Anti-APPI Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
